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Inflammation

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  • Allopregnanolone | GABA-A positive allosteric modulator
    Allopregnanolone | GABA-A positive allosteric modulator
    $70.00
    Allopregnanolone (516-54-1) is an endogenous neurosteroid which acts as a positive allosteric modulator of GABAA receptors.1,2 Recently FDA approved (Brexanolone) for postpartum depression.3 Inhibits TLR4 receptor activation...

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  • Focus Biomolecules cell signaling tech supplier, chemical structure Ambroxol HCl | Free radical scavenger | CAS 18683-91-5
    Ambroxol HCl | Free radical scavenger
    $50.00
    Ambroxol HCl (18683-91-5) is a radical scavenger with anti-inflammatory activity. Blocks the generation of reactive oxygen species by bronchoalveolar lavage cells, inhibits doxorubicin-induced lipid peroxidation (70 mg/kg in...

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  • Focus Biomolecules supplier, chemical structure of Amlexanox | TBK1 inhibitor / Antidiabetic | CAS 68302-57-8
    Amlexanox | TBK1 inhibitor / Antidiabetic
    $40.00
    Amlexanox (68302-57-8) improves obesity-related metabolic dysfunction in mouse models.1 Increases thermogenesis and weight loss, decreases steatosis and improves insulin sensitivity.  Inhibits TANK-binding kinase 1...

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  • Anacardic Acid | HAT inhibitor
    Anacardic Acid | HAT inhibitor
    $35.00
    Anacardic acid (16611-84-0) is a natural product found in cashew nut oil. It is an inhibitor of the histone acetyltransferases p300 and PCAF (IC50’s = 8.5 and 5.0 µM respectively).1 Anacardic acid sensitizes...

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  • Focus Biomolecules supplier, Andrographolide | Induces mitochondrial-mediated apoptosis in lymphoma cells | CAS 5508-58-7
    Andrographolide | Induces mitochondrial -mediated apoptosis in lymphoma cells
    $34.00
    Andrographolide (5508-58-7) is the major bioactive component of the medicinal plant Andrographis paniculate. Demonstrates anti-inflammatory anti-apoptotic, anti-viral and anti-proliferative effects in vitro and in vivo...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure AS-041164 | PI 3-Kgamma inhibitor | CAS 6318-41-8
    AS-041164 | PI 3-Kgamma inhibitor
    $60.00
    AS-041164 (6318-41-8) is a potent, ATP-competitive, and isoform-selective PI3-Kinase inhibitor (IC50 = 0.07, 0.24, 1.45, and 1.70 μM for the γ, α, β, and δ isoforms respectively).1 Cell permeable...

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  • AS-605240 | PI 3-Kinase inhibitor
    AS-605240 | PI 3-Kinase inhibitor
    $50.00
    AS-605240 (648450-29-7) is a potent and selective inhibitor of PI 3-kinase γ (PI 3-Kγ), IC50 = 8 nM displaying 30-fold selectivity over PI 3-Kδ and PI 3-Kβ and 7.5-fold selectivity over PI 3-Kα1...

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  • Focus Biomolecules supplier, chemical structure of Ascomycin | FKBP ligand immunosuppressant | CAS 11011-38-4
    Ascomycin | FKBP ligand immunosuppressant
    $35.00
    Ascomycin (11011-38-4) is an analog of FK-506 (Cat.# 10-1103). Potent immunosuppressant1. Binds to FKBP122 and inhibits calcineurin and NFAT. Ascomycin displays antiinflammatory effects in skin diseases3. Cell permeable and...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Auranofin | IKK inhibitor | CAS 34031-32-8
    Auranofin | IKK inhibitor
    $50.00
    Auranofin (34031-32-8) is a disease-modifying antirheumatic drug (DMARD) , It is a potent inhibitor of selenoenzyme thioredoxin reductase and IκB kinase (IKK) by modifying Cys-179. Auranofin is an efficient inducer of...

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  • Focus Biomolecules reagent supplier, chemical structure of Baicalein | Protein tyrosine kinase inhibitor | CAS 491-67-8
    Baicalein | Inhibitor of protein tyrosine kinase in leukemia (CEM cells)
    $40.00
    Baicalein (491-67-8) is an inhibitor of protein tyrosine kinase in leukemia (CEM) cells. Induces cell cycle arrest and apoptosis1. Originally reported as a selective inhibitor of 12-lipoxygenase, baicalein has since been...

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  • Bakuchiol | Antioxidant
    Bakuchiol | Antioxidant
    $0.00
    Bakuchiol (10309-37-2) is a natural terpenoid antioxidant.1 Inhibits oxidative stress-induced decrease in mitochondrial membrane potential and associated release of pro-apoptotic factors.2 Protects against acute lung injury...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of BAY 11-7082 | IKK inhibitor | CAS 19542-67-7
    BAY 11-7082 | IKK inhibitor
    $60.00
    BAY 11-7082 (19542-67-7) selectively inhibits TNFα-induced phosphorylation of IκB-α leading to decreased nuclear NF-κB and decreased adhesion molecule expression without affecting constitutive...

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  • Focus Biomolecules cell signaling supplier, chemical structure of BML-111 | LXA agonist, antiinflammatory | CAS 78606-80-1
    BML-111 | LXA agonist, antiinflammatory
    $50.00
    BML-111 (78606-80-1) novel truncated analog of lipoxin A4 which retains anti-inflammatory activity.1 Inhibits LTB4-induced leukocyte chemotaxis, IC50=5 nM).1 Attenuates hemorrhagic shock-induced acute lung injury in a rat...

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  • C-176 | STING Antagonist
    C-176 | STING Antagonist
    $50.00
    C-176 (314054-00-7) is an inhibitor of the signaling molecule STING in mouse cells. It covalently binds to Cys91 of STING preventing activation via blockade of palmitoylation at Cys91. Treatment of Trex-/- mice with C-176...

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  • C-178 | STING Antagonist
    C-178 | STING Antagonist
    $50.00
    C-178 (329198-87-0) is an inhibitor of the signaling molecule STING in mouse cells. It covalently binds to Cys91 of STING preventing activation via blockade of palmitoylation at Cys91. References/Citations 1) Haag et al...

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  • Focus Biomolecules reagent supplier, chemical structure of C-DIM 12 | Nurr1 activator; NFkB inhibitor | CAS 178946-89-9
    C-DIM 12 | Nurr1 activator; NFkB inhibitor
    $55.00
    C-DIM 12 (178946-89-9) activates the orphan nuclear receptor Nurr1 and inhibits bladder cancer growth.1,2 Nurr1 is a suppressor of NFkB-related neuroinflammatory genes in microglia and astrocytes and C-DIM 12 suppresses...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of CAPE | Inhibits NFkB activation | CAS 104594-70-9
    CAPE | Inhibits NFkB activation
    $30.00
    CAPE (104594-70-9) is an antioxidant that inhibits NFκB activation and the growth of transformed cells. CAPE inhibits lipid peroxidation and displays antiinflammatory activity. Cell permeable. References/Citations1)...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Capsaicin (natural) | TRPV1 agonist | CAS 404-86-4
    Capsaicin (natural) | TRPV1 agonist
    $80.00
    Capsaicin (404-86-4) is a vanilloid agonist known to activate the transient receptor potential channel vanilloid subfamily member 1 (TRPV1)1,2 and to possess analgesic3, anti-inflammatory4 and hypolocomotor effects5. SEVERE...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Cardamonin | NFkB inhibitor | CAS 19309-14-9
    Cardamonin | NFkB inhibitor
    $50.00
    Cardamonin (19309-14-9) inhibits NF-κB activation via inhibition of IκBα degradation and phosphorylation, IκB kinase activation and NF-κB nuclear translocation1,2. Cardamonin displays...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Celastrol | Proteasome inhibitor | CAS 34157-83-0
    Celastrol | Proteasome inhibitor
    $50.00
    Celastrol (34157-83-0) displays potent antioxidant and anti-inflammatory activity. Inhibits NFkB (IC50=270 nM).  It induces heat shock response and cytoprotection in various cells. Inhibits 20S proteasome chymotrypsin...

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