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Leukotrienes

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of MK-571 | Cys LT1 antagonist | CAS 115104-28-4
    $60.00
    MK-571 (115104-28-4) is a potent (EC50 = 1.3nM) and selective Leukotriene D4 antagonist (LTD4)1 displaying inverse agonist activity2. Blocks binding of LTD4 to human (Ki = 0.22 nM) and guinea pig (Ki = 2.1 nM) lung membranes...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of MK-886 | FLAP inhibitor | CAS 118414-82-1
    $70.00
    MK-886 (118414-82-7) is an inhibitor of leukotriene biosynthesis(IC50 = 2.5 nM in human PMN)1 via 5-lipoxygenase-activating protein (FLAP) inhibition (IC50 = 30 nM)2. MK-886 also inhibits PPARα (80% inhibition at 10...

  • Focus Biomolecules supplier, chemical structure of Montelukast sodium | Leukotriene & GPR17 antagonist | CAS 151767-02-1
    $60.00
    Montelukast sodium (151767-02-1) is a potent, selective CysLT1 receptor (leukotriene D4) antagonist (Ki = 0.18 nM).1,2 Displays anti-inflammatory and anti-asthmatic effects. Clinically useful agent for treatment of chronic...

  • Focus Biomolecules offers cell signaling reagent, Zafirlukast | HSP70 inhibitor, leukotriene antagonist | CAS 107753-78-6
    $28.00
    Zafirlukast (107753-78-6) is a competitive and selective leukotriene receptor antagonist1. Also inhibits calcium ionophore induced production of leukotriene B4 and leukotriene C4, which suggests a potential 5-LO inhibitory...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Zileutin | 5-LO inhibitor | CAS 111406-87-2
    $30.00
    Zileuton (111406-87-2) is a reversible inhibitor (IC50 = 500nM RBL-1 cells, 300nM rat PMNL cells) of 5-Lipoxygenase (5-LO).1 It also inhibited leukotriene B4 biosynthesis (IC50's = 400nM rat PMNL, 400nM human PMNL and 900nM...

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