Inflammatory diseases
Showing 1–12 of 15 results
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Inflammation
AS-605240 | PI 3-Kinase inhibitor
AS-605240 (648450-29-7) is a potent and selective inhibitor of PI 3-kinase γ (PI 3-Kγ), IC50 = 8 nM displaying 30-fold selectivity over PI 3-Kδ and...$50.00 – $190.00 Select options -
Approved Drugs
Auranofin | IKK inhibitor
Auranofin (34031-32-8) is a disease-modifying antirheumatic drug (DMARD) , It is a potent inhibitor of selenoenzyme thioredoxin reductase and IκB k...$50.00 Select options -
Apoptosis
Baicalein | Inhibitor of protein tyrosine kinase in leukemia (CEM cells)
Baicalein (491-67-8) is an inhibitor of protein tyrosine kinase in leukemia (CEM) cells. Induces cell cycle arrest and apoptosis1. Originally repor...$40.00 – $148.00 Select options -
Approved Drugs
Baricitinib | JAK 1/2 inhibitor
Baricitinib (1187594-09-7), approved by the FDA for two inflammatory disorders, rheumatoid arthritis and alopecia areata, selectively inhibits Janu...$50.00 – $150.00 Select options -
Bioinorganic chemistry
Divin | Divisome assembly inhibitor
Divin is an iron, cobalt, and copper chelator that arrests the late stages of cytokinesis in bacteria by blocking the physical process of constrict...$75.00 – $250.00 Select options -
Arthritis
GW-2580 | cFMS kinase inhibitor
GW-2580 (870483-87-7) is a potent and selective inhibitor of cFMS receptor kinase. Completely inhibits cFMS in vitro at 60 nM with no activity agai...$72.00 – $288.00 Select options -
Immunology
IQ-1S | JNK3 inhibitor
IQ-1S (1421610-21-0) is a JNK3 inhibitor (Kd = 87, 360 and 390 nM for JNK3, JNK2 and JNK1, respectively). Displays anti-inflammatory and immunosupp...$40.00 – $140.00 Select options -
Approved Drugs
Leflunomide | Immunosuppressant
Leflunomide (75706-12-6) pyrimidine biosynthesis inhibitor DMARD (disease-modifying antirheumatic drug)1. Displays immunomodulatory activity inhibi...$40.00 – $160.00 Select options -
Approved Drugs
Minocycline HCl | Neuroprotective; antiapoptotic
Minocycline HCl (13614-98-7) displays antiapoptotic, anti-inflammatory1 activity. Prevents neuropathic pain in a rat sciatic nerve injury model1. R...$38.00 – $152.00 Select options -
Arthritis
MS-275 (Entinostat) | HDAC inhibitor
MS-275 (Entinostat - 209783-80-2) is a potent HDAC inhibitor. Selective for HDAC1 (IC50 = 300 nM) over HDAC3 (IC50 = 8 μM) and HDAC8 (IC50 100 μM)....$50.00 – $160.00 Select options -
Alzheimers
Na Valproate | HDAC inhibitor
Sodium Valproate (1069-66-5) is a histone deacetylase inhibitor (IC50 = 400µM).1 Demonstrates neuroprotective, anticancer, and anti-inflammatory ac...$26.00 Select options -
Approved Drugs
Tofacitinib | JAK inhibitor
Tofacitinib (477600-75-2) is a potent pan-JAK inhibitor, IC50s=1, 20 and 112 nM for JAK3, JAK2 and JAK1 respectively.1 Displays potent antiinflamma...$60.00 – $220.00 Select options
