Inflammatory diseases
Showing 1–12 of 20 results
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Inflammation
AS-605240 | PI 3-Kinase inhibitor
AS-605240 (648450-29-7) is a potent and selective inhibitor of PI 3-kinase γ (PI 3-Kγ), IC50 = 8 nM displaying 30-fold selectivity over PI 3-Kδ and...$50.00 – $190.00 Select options -
Approved Drugs
Auranofin | IKK inhibitor
Auranofin (34031-32-8) is a disease-modifying antirheumatic drug (DMARD) , It is a potent inhibitor of selenoenzyme thioredoxin reductase and IκB k...$50.00 Select options -
Apoptosis
Baicalein | Inhibitor of protein tyrosine kinase in leukemia cells
Baicalein (491-67-8) is an inhibitor of protein tyrosine kinase in leukemia (CEM) cells. Induces cell cycle arrest and apoptosis.1 Originally repor...$40.00 – $148.00 Select options -
Approved Drugs
Baricitinib | JAK 1/2 inhibitor
Baricitinib (1187594-09-7), approved by the FDA for two inflammatory disorders, rheumatoid arthritis and alopecia areata, selectively inhibits Janu...$48.00 – $100.00 Select options -
Bioinorganic chemistry
Divin | Divisome assembly inhibitor
Divin (1443321-11-6) is an iron, cobalt, and copper chelator that arrests the late stages of cytokinesis in bacteria by blocking the physical proce...$75.00 – $250.00 Select options -
New Products
Filgotinib | JAK1 inhibitor
Filgotinib (1206161-97-8) is a potent and selective JAK1 inhibitor (IC50s=10, 28, 810 and 116 nM for JAK1, JAK2, JAK3 and TYK2 respectively).2 Dis...$65.00 – $220.00 Select options -
New Products
GSK2982772 | RIP1 inhibitor
GSK2982772 (1622848-92-3) is a highly selective inhibitor of Receptor-interacting Protein 1 kinase (RIP1); IC50 = 1.6 nM.1 Novel anti-inflammatory ...$95.00 – $350.00 Select options -
Arthritis
GW-2580 | cFMS kinase inhibitor
GW-2580 (870483-87-7) is a potent and selective inhibitor of cFMS receptor kinase. Completely inhibits cFMS in vitro at 60 nM with no activity agai...$72.00 – $288.00 Select options -
Immunology
IQ-1S | JNK3 inhibitor
IQ-1S (1421610-21-0) is a JNK3 inhibitor (Kd = 87, 360 and 390 nM for JNK3, JNK2 and JNK1, respectively). Displays anti-inflammatory and immunosupp...$40.00 – $140.00 Select options -
Arthritis
Kenpaullone | GSK-3ß/CDK/KLF4 inhibitor
Kenpaullone (142273-20-9) inhibits GSK-3β (IC50=0.23 µM) as well as several cyclin-dependent kinases (CDKs), IC50=0.4, 0.68 and 0.85 µM for cdk1, c...$80.00 – $240.00 Select options -
Approved Drugs
Leflunomide | Immunosuppressant
Leflunomide (75706-12-6) pyrimidine biosynthesis inhibitor DMARD (disease-modifying antirheumatic drug).1 Displays immunomodulatory activity inhibi...$40.00 – $160.00 Select options -
Arthritis
Methotrexate | Dihydrofolate reductase inhibitor
Methotrexate (133073-73-1) is a synthetic folic acid analog with immunosuppressant and cancer chemotherapeutic activity.1 Inhibits thymidylate synt...$50.00 – $150.00 Select options
