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Inflammatory Diseases

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  • AS-605240 | PI 3-Kinase inhibitor
    AS-605240 | PI 3-Kinase inhibitor
    $50.00
    AS-605240 (648450-29-7) is a potent and selective inhibitor of PI 3-kinase γ (PI 3-Kγ), IC50 = 8 nM displaying 30-fold selectivity over PI 3-Kδ and PI 3-Kβ and 7.5-fold selectivity over PI 3-Kα1...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Auranofin | IKK inhibitor | CAS 34031-32-8
    Auranofin | IKK inhibitor
    $50.00
    Auranofin (34031-32-8) is a disease-modifying antirheumatic drug (DMARD) , It is a potent inhibitor of selenoenzyme thioredoxin reductase and IκB kinase (IKK) by modifying Cys-179. Auranofin is an efficient inducer of...

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  • Focus Biomolecules reagent supplier, chemical structure of Baicalein | Protein tyrosine kinase inhibitor | CAS 491-67-8
    Baicalein | Inhibitor of protein tyrosine kinase in leukemia (CEM cells)
    $40.00
    Baicalein (491-67-8) is an inhibitor of protein tyrosine kinase in leukemia (CEM) cells. Induces cell cycle arrest and apoptosis1. Originally reported as a selective inhibitor of 12-lipoxygenase, baicalein has since been...

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  • Baricitinib | JAK 1/2 inhibitor
    Baricitinib | JAK 1/2 inhibitor
    $50.00
    Baricitinib (1187594-09-7), approved by the FDA for two inflammatory disorders, rheumatoid arthritis and alopecia areata, selectively inhibits Janus kinase 1 (IC50 = 5.9 nM) and 2 (5.7 nM), over 3 (0.56 µM).1 It...

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  • Filgotinib | JAK1 inhibitor
    Filgotinib | JAK1 inhibitor
    $65.00
    Filgotinib (1206161-97-8) is a potent and selective JAK1 inhibitor (IC50s=10, 28, 810 and 116 nM for JAK1, JAK2, JAK3 and TYK2 respectively.2  Displays potent anti-inflammatory activity in various models.1,2 ...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of GSK2982772 | RIPK1 inhibitor | CAS
    GSK2982772 | RIPK1 inhibtior
    $95.00
    GSK2982772 (1622848-92-3) is a highly selective inhibitor of Receptor-interacting Protein 1 kinase (RIP1); IC50 = 1.6 nM.1 Novel anti-inflammatory agent previously in clinical trials for psoriasis, rheumatoid arthritis, and...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of GW-2580 | cFMS kinase inhibitor | CAS 870483-87-7
    GW-2580 | cFMS kinase inhibitor
    $72.00
    GW-2580 (870483-87-7) is a potent and selective inhibitor of cFMS receptor kinase. Completely inhibits cFMS in vitro at 60 nM with no activity against 26 other kinases1. Completely inhibits CSF-1 induced growth of mouse...

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  • IQ-1S | JNK3 inhibitor
    IQ-1S | JNK3 inhibitor
    $40.00
    IQ-1S (1421610-21-0) is a JNK3 inhibitor (Kd = 87, 360 and 390 nM for JNK3, JNK2 and JNK1, respectively). Displays anti-inflammatory and immunosuppresive activity. Inhibits LPS-induced proinflammatory cytokine and nitric...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Leflunomide | Immunosuppressant | CAS 75706-12-6
    Leflunomide | Immunosuppressant
    $40.00
    Leflunomide (75706-12-6) pyrimidine biosynthesis inhibitor DMARD (disease-modifying antirheumatic drug)1. Displays immunomodulatory activity inhibiting the mitochondrial enzyme dihydroorotate dehydrogenase (DHODH)2; however...

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  • Focus Biomolecules supplier, chemical structure of Minocycline HCl | Neuroprotective | Antiapoptotic | CAS 13614-98-7
    Minocycline HCl | Neuroprotective; antiapoptotic
    $38.00
    Minocycline HCl (13614-98-7) displays antiapoptotic, anti-inflammatory1 activity. Prevents neuropathic pain in a rat sciatic nerve injury model1. Reduces MMP-9 activity2. Attenuates disease severity in mouse models of...

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  • Focus Biomolecules supplier, chemical structure of MS-275 (Entinostat) | HDAC inhibitor | CAS 209783-80-2
    MS-275 (Entinostat) | HDAC inhibitor
    $50.00
    MS-275 (Entinostat - 209783-80-2) is a potent HDAC inhibitor. Selective for HDAC1 (IC50 = 300 nM) over HDAC3 (IC50 = 8 μM) and HDAC8 (IC50 100 μM).1 In vivo, MS-275, has been shown to inhibit tumor growth via induction...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Tofacitinib | JAK inhibitor | CAS 477600-75-2
    Tofacitinib | JAK inhibitor
    $60.00
    Tofacitinib (477600-75-2) is a potent pan-JAK inhibitor, IC50s=1, 20 and 112 nM for JAK3, JAK2 and JAK1 respectively.1 Displays potent antiinflammatory2 and immunosuppressant3 activity. Promotes a white-to-brown metabolic...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Trametinib | MEK inhibitor | CAS 871700-17-3
    Trametinib | MEK inhibitor
    $40.00
    Trametinib (871700-17-3) is a highly potent (IC50 uMEK1 = 0.7 nM, pp-MEK1 = 14.9 nM)1 and selective MEK inhibitor displaying selective inhibition of proliferation in various BRAF mutant cancer cell lines (IC50 ACHN = 9.8 nM;...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure Tubastatin A HCl | HDAC inhibitor | CAS 1310693-92-5
    Tubastatin A HCl | HDAC-6 inhibitor
    $55.00
    Tubastatin A (1310693-92-5) is a potent and highly selective inhibitor of HDAC6 (IC50 = 15 nM, >1000-fold selectivity against other HDAC isoforms, approx. 60-fold versus HDAC8).1 It displayed anti-inflammatory and...

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  • VX-702 | P38alpha MAP kinase inhibitor
    VX-702 | P38alpha MAP kinase inhibitor
    $40.00
    VX-702 (745833-23-2) is a  potent and selective inhibitor of p38 MAP kinases, p38α MAPK and p38β (KD = 3.7 and 17 nM respectively).1 Inhibits IL-6, IL-1β and TNFα production in LPS-primed blood.1...

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