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  • AS-605240 | PI 3-Kinase inhibitor
    AS-605240 (648450-29-7) is a potent and selective inhibitor of PI 3-kinase γ (PI 3-Kγ), IC50 = 8 nM displaying 30-fold selectivity over PI 3-Kδ and PI 3-Kβ and 7.5-fold selectivity over PI 3-Kα1...

  • Auranofin | IKK inhibitor
    Auranofin (34031-32-8) is a disease-modifying antirheumatic drug (DMARD) , It is a potent inhibitor of selenoenzyme thioredoxin reductase and IκB kinase (IKK) by modifying Cys-179. Auranofin is an efficient inducer of...

  • Baicalein | Inhibitor of protein tyrosine kinase in leukemia (CEM cells)
    Baicalein (491-67-8) is an inhibitor of protein tyrosine kinase in leukemia (CEM) cells. Induces cell cycle arrest and apoptosis1. Originally reported as a selective inhibitor of 12-lipoxygenase, baicalein has since been...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of GW-2580 | cFMS kinase inhibitor | CAS 870483-87-7
    GW-2580 (870483-87-7) is a potent and selective inhibitor of cFMS receptor kinase. Completely inhibits cFMS in vitro at 60 nM with no activity against 26 other kinases1. Completely inhibits CSF-1 induced growth of mouse...

  • IQ-1S | JNK3 inhibitor
    IQ-1S (1421610-21-0) is a JNK3 inhibitor (Kd = 87, 360 and 390 nM for JNK3, JNK2 and JNK1, respectively). Displays anti-inflammatory and immunosuppresive activity. Inhibits LPS-induced proinflammatory cytokine and nitric...

  • Leflunomide | Immunosuppressant
    Leflunomide (75706-12-6) pyrimidine biosynthesis inhibitor DMARD (disease-modifying antirheumatic drug)1. Displays immunomodulatory activity inhibiting the mitochondrial enzyme dihydroorotate dehydrogenase (DHODH)2; however...

  • Minocycline HCl | Neuroprotective; antiapoptotic
    Minocycline HCl (13614-98-7) displays antiapoptotic, anti-inflammatory1 activity. Prevents neuropathic pain in a rat sciatic nerve injury model1. Reduces MMP-9 activity2. Attenuates disease severity in mouse models of...

  • Focus Biomolecules supplier, chemical structure of MS-275 (Entinostat) | HDAC inhibitor | CAS 209783-80-2
    MS-275 (Entinostat - 209783-80-2) is a potent HDAC inhibitor. Selective for HDAC1 (IC50 = 300 nM) over HDAC3 (IC50 = 8 μM) and HDAC8 (IC50 100 μM).1 In vivo, MS-275, has been shown to inhibit tumor growth via induction...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Tofacitinib | JAK inhibitor | CAS 477600-75-2
    Tofacitinib (477600-75-2) is a potent pan-JAK inhibitor, IC50s=1, 20 and 112 nM for JAK3, JAK2 and JAK1 respectively.1 Displays potent antiinflammatory2 and immunosuppressant3 activity. Promotes a white-to-brown metabolic...

  • Trametinib | MEK inhibitor
    Trametinib (871700-17-3) is a highly potent (IC50 uMEK1 = 0.7 nM, pp-MEK1 = 14.9 nM)1 and selective MEK inhibitor displaying selective inhibition of proliferation in various BRAF mutant cancer cell lines (IC50 ACHN = 9.8 nM;...

  • Tubastatin A  HCl | HDAC inhibitor
    Tubastatin A (1310693-92-5) is a potent and highly selective inhibitor of HDAC6 (IC50 = 15 nM, >1000-fold selectivity against other HDAC isoforms, approx. 60-fold versus HDAC8).1 It displayed anti-inflammatory and...

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