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Ion and Other Channels

Ion Channels are pore-forming proteins that allow the selective passage of ions through plasma or intracellular organelle membranes based on an electric gradient. In addition to transducing electrical currents in the body, they play a role in cellular signaling, pH regulation, and cell volume regulation. Ion channels can be defined by what opens and closes the channel: voltage-gated channels open and close based on the voltage gradient across the plasma membrane or ligand-gated channels by the binding of various ligands to the channel. They are also be defined by the type of ion that selectively passes through (calcium, sodium, potassium etc.) or by the physical stimulation that opens or closes them (mechanosensitive, light sensitive, or temperature sensitive). Many disease states are caused by perturbed ion channel function (channelopathies) including epilepsy, cystic fibrosis, long QT syndrome, and various musculo-skeletal disorders. Pharmacologic manipulation of ion channels is widely used to treat cardiovascular disorders, pain, diabetes, constipation and is being investigated for use in cancer, inflammation, immunomodulation, kidney diseases and infection.

View All Ion and Other Channels

Calcium

View All Calcium Channel Reagents

Sodium

View All Sodium Channel Reagents

Potassium

  • Cereulide

    Potent ionophore with high selectivity of K+

  • ML-297

    ML-297 is a selective GIRK1/2 channel activator

View All Potassium Channel Reagents

TRP

  • AC1903

    AC1903 is a potent and selective TRPC5 blocker

  • PBMC

    Potent and selective inhibitor of TRPM8 channels

  • GSK1702934A

    GSK1702934A is a TRPC3/6 activator

View All TRP Channel Reagents

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