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  • 4,9-Anhydrotetrodotoxin | Selective sodium channel blocker
    4,9-Anhydrotetrodotoxin (13072-89-4) is a highly selective blocker of the Na(v1.6) sodium channel. (IC50's: Na(v1.2) = 260 nM, Na(v1.3) = 341 nM, Na(v1.4) = 988 nM, Na(v1.5) = 11.6 μM, Na(v1.6) = 7.8 nM, Na(v1.7) = 1.27...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of A-803467 | NaV1.8 blocker | CAS 944261-79-4
    A-803467 (944261-79-4) is a potent, selective inhibitor of the TTX-resistant voltage-gated sodium channel Nav1.8. Nav1.8 is preferentially expressed in sensory neurons, and inhibition attenuates both inflammatory and...

  • AA43279 | Nav1.1 activator
    AA43279 (354812-16-1) is a selective Nav1.1activator. In HEK-293 cells expressing human Nav1.1 channels AA43279 increased the Nav1.1-mediated current in a concentration dependent manner (EC50=9.5 μM). In rat hippocampal...

  • Benzamil HCl | Sodium channel blocker
    Benzamil HCl (2898-76-2) is a derivative of amiloride. Potent sodium channel blocker

  • CGP-37157 | MPTP inhibitor
    CGP-37157 (75450-34-9) inhibits the mitochondrial Na+-Ca2+ exchanger (NCX) in isolated heart mitochondria, IC50=0.36 mM.1 Does not inhibit the plasmalemmal NCX.2  Also inhibits voltage-gated Ca2+ channels in intact...

  • Deltamethrin | Calcineurin inhibitor; displays neurotrophic activity
    Deltamethrin (52918-63-5) is reported to be an inhibitor of calcineurin (PP2B), IC50~100 pM1 but this activity has been disputed2. Markedly enhances the expression of BDNF in cultured rat cortical neurons and displays...

  • Disopyramide | Antiarrhythmic
    Disopyramide (3737-09-5) is a clinically useful sodium channel blocker used as an antiarrhythmic for treatment of ventricular tachycardia1 and hypertrophic cardiomyopathy2.  It decreases the rate of diastolic...

  • Focus Biomolecules supplier, chemical structure of GBR-12909 2HCl | Dopamine reuptake inhibitor | CAS 67469-78-7
    GBR-12909 2HCl (67469-78-7) is a potent and selective inhibitor of dopamine reuptake (Ki = 1 nM) with greater than 100 fold selectivity over serotonin and noradrenaline.1 GBR-12909 2HCl also acts as a potent sigma...

  • Ranolazine | Selective sodium channel blocker
    Ranolazine (142387-99-3) is an FDA-approved drug used for the treatment of chronic angina. It inhibits the late inward sodium current in heart muscle leading to decreased intracellular calcium levels.1 Ranolazine blocks Nav...

  • Riluzole | Sodium channel blocker / Neuroprotective
    Riluzole (1744-22-5) is a clinically useful drug for the treatment of amyotrophic lateral sclerosis (ALS).1 Riluzole inhibits glutamate release via inactivation of voltage-dependent ion channels, effects expression and...

  • Rufinamide | Anticonvulsant / Improves cognition
    Rufinamide (106308-44-5) is a clinically useful anticonvulsant medication.1 Its mechanism of action is believed to be inhibition of Nav1.1 and Nav1.6 activation.2  Rufinamide improved cognitive function and increased...

  • Focus Biomolecules cell signaling reagent supplier, structure of SKF-96365 | TRPC channel blocker | CAS 130495-35-1
    SKF-96365 (130495-35-1) is an inhibitor of receptor-mediated calcium entry (RMCE) with IC50's of 8.5 μM for ADP stimulated platelets and 11.7 μM for thrombin stimulated platelets. Also inhibits Voltage-gated Ca2+ but...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Veratridine | Na channel opener | CAS 71-62-5
    Veratridine (71-62-5) is a steroidal alkaloid voltage-gated Na+ channel activator1. Veratridine may be used to increase Na+ concentration in cardiomyocytes2 and in cultured sympathetic neurons3. Toxic: LD50=1.35 mg/Kg (mouse...

  • Vinpocetine | 42971-09-5 | Structure | Supplier
    Vinpocetine (42971-09-5) is a phosphodiesterase PDE1 inhibitor (IC50=21 μM).1 Also blocks voltage-gated Na+ channels, IC50=44.2 μM (potency similar to phenytoin), a mechanism which may contribute to its neuroprotective...

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