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TRP

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  • 2-APB | 524-95-8 | Structure | Supplier
    $25.00
    2-APB (524-95-8) is an IP3 receptor antagonist (IC50=42 μM).1 Inhibits store-operated Ca2+ channels at high concentrations (50 μM) but stimulates at low concs. (<10 μM).2 Modulates TRP channels,...

  • A-967079 | 1170613-55-4 | Structure | Supplier
    $78.00
    A-967079 (1170613-55-4) is a TRPA1 antagonist. Active in rat models.1 Cell permeable References/Citations1) McGaraughty et al. (2010), TRPA1 modulation of spontaneous and mechanically evoked firing of spinal neurons in...

  • AC1903 | TRPC5 blocker
    $70.00
    AC1903 (831234-13-0) is a potent and selective TRPC5 blocker. Suppresses severe proteinuria and prevents podocyte loss in a transgenic rat model of focal segmental glomerulosclerosis. It also provided therapeutic benefit in...

  • AP-18 | 552244-94-7 | Structure | Supplier
    $70.00
    AP-18 (55224-94-7) is a selective TRPA1 (transient receptor potential A1) channel blocker (IC50 = 3.1 and 4.5 μM at human and mouse TRPA1 respectively). References/Citations1) Petrus et al. (2007) A role of TRPA1 in...

  • BCTC | 393514-24-4 | Structure | Supplier
    $70.00
    BCTC (393514-24-4) is a vanilloid receptor I (TRPV1) antagonist, IC50 = 35 nM for capsaicin-induced and 6 nM for acid-induced TRPV1 activation. Displays analgesic activity in rat models of neuropathic pain. BCTC is orally...

  • Capsaicin (natural) | TRPV1 agonist
    $80.00
    Capsaicin (404-86-4) is a vanilloid agonist known to activate the transient receptor potential channel vanilloid subfamily member 1 (TRPV1)1,2 and to possess analgesic3, anti-inflammatory4 and hypolocomotor effects5. SEVERE...

  • Evodiamine | TRPV1 agonist, anti-inflammatory, antiangiogenic
    $25.00
    Evodiamine (518-17-2) is a quinolone alkaloid isolated from Evodia rutaecarpa.1 Evodia Rutaecarpa is a very popular herb used in traditional chinese medicine to treat a variety of ailments. Evodiamine has been shown to...

  • GSK-1016790A | 942206-85-1 | Structure | Supplier
    $78.00
    GSK-1016790A (942206-85-1) is a novel and potent TRPV4 channel agonist. GSK-1016790A induced Ca2+ influx in mouse and human TRPV4 expressing HEK cells (EC50 values of 18 and 2.1 nM, respectively), and evoked a dose-dependent...

  • GSK-1702934A | Structure | Supplier
    $110.00
    GSK1702934A is a TRPC3 activator.  In whole-cell patch-clamp experiments in HEK293 cells transduced with recombinant human TRPC3 or TRPC6, GSK-1702934A activated the TRPC3 and TRPC6 current with EC50 of 0.08 mM and...

  • GSK-417651A | Structure | Supplier
    $100.00
    GSK417651A is a TRPC inhibitor. In whole-cell patch-clamp experiments in HEK293 cells transfected with recombinant human TRPC3 or TRPC6, GSK417651A inhibited both TRPC3 and TRPC6 current with IC50 of ~0.04 μM...

  • HC-030031 | 349085-38-7 | Structure | Supplier
    $70.00
    HC-030031 (349085-38-7) inhibits TRPA1 channel. References/Citations1) McNamara et al. (2007), TRPA1 mediates formalin-induced pain; Proc. Natl. Acad. Sci., 104...

  • HC-067047 | 883031-03-6 | Structure | Supplier
    $58.00
    HC-067047 (883031-03-6) is a potent reversible and selective TRPV4 antagonist. Active at mouse, human and rat TRPV4, IC50 = 17, 48 and 133 nM respectively. Also inhibits the endogenous TRPV4-mediated response to 4α-PDH...

  • Icilin | TRPM8 inhibitor
    $65.00
    Icilin (36945-98-9) is an agonist of cold-sensitive TRP channels with 2.5-fold greater efficacy and 200-fold greater potency than menthol (EC50 = 0.36 μM for CRM1, rat orthologue of TRPM8).1 Agonist at TRPM8 (EC50 = 0.2...

  • KB-R7943 mesylate | 182004-65-5 | Structure | Supplier
    $65.00
    KB-R7943 (182004-65-5) is a potent and selective inhibitor of the reversed Na+/Ca2+ exchanger (NCE or NCX; IC50's = 1.2-2.4 μM in cardiomyocytes, smooth muscle cells, NCX1-transfected fibroblasts1; 0.7 μM in cultured...

  • ML-204 | TRPC4 blocker
    $60.00
    ML-204 (5485-86-1) is a selective blocker of TRPC4 channels (IC50 = 0.96 - 2.6 μM, depending on assay). Displays 19-fold selectivity against TRPC6 and 9-fold selectivity against TRPC5.  Has no significant activity at...

  • ML-SA1 | 332382-54-4 | Structure  | supplier
    $75.00
    ML-SA1 (332382-54-4) is a TRPML 1,2 and 3 channel activator.1 Does not activate TRPM2, TRPV2, TRPV3, TRPC6 or TRPA1 channels.2 ML-SA1 robustly activates whole cell TRPML1-4A and whole-endolysosome TRPML1 and is...

  • PBMC | Structure | Supplier
    $70.00
    PBMC is a potent and selective inhibitor of TRPM8 channels. PBMC inhibits both chemical and thermal activation of TRPM8.1 Reverses the menthol and cold-induced facilitation of the micturition reflex.2 PBMC...

  • Polygodial | 6754-20-7 | Structure | Supplier
    $60.00
    Polygodial (6754-20-7) is a TRPA1 agonist (EC50=400 nM)1. A naturally occurring drimane sesquiterpene dialdehyde found in a variety of plant species including water pepper (Polygonum hydropiper). Polygodial has been used in...

  • Pyr3 | 1160514-60-2 | Structure | Supplier
    $111.00
    Pyr3 (1160514-60-2) is a selective antagonist of the TRP canonical 3 channel (TRPC3)1 which can function as a receptor-operated channel2. A useful tool for dissecting GPCR-downstream signaling mechanisms3. Pyr3 may be...

  • SB-366791 | 472981-92-3 | Structure | Supplier
    $60.00
    SB-366791 (472981-92-3) is a potent (IC50 = 0.7 µM) and selective TRPV1 antagonist.1,2 Selective for TRPV1 in a panel of 47 different binding assays. References/Citations1) Gunthorpe, et al., (2004) Identiication and...

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