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AC1903 | TRPC5 blocker

CAS:
831234-13-0
Catalog Number:
10-3375
Activity:
TRPC5 blocker
Chemical Name:
1-Benzyl-1H-benzoimidazol-2-yl)-furan-2-ylmethyl-amine
Molecular Weight:
303.36
Molecular Formula:
C19H17N3O
Solubility:
Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 25 mg/ml)
Physical Properties:
Beige solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

AC1903 (831234-13-0) is a potent and selective TRPC5 blocker. Suppresses severe proteinuria and prevents podocyte loss in a transgenic rat model of focal segmental glomerulosclerosis. It also provided therapeutic benefit in a rat model of hypertensive proteineuric kidney disease. The use of this selective tool compound provided a mechanistic rationale for targeting TRPC5 channels in progressive chronic kidney diseases and paves the way for the discovery of new therapeutics. Active in vivo.

References/Citations:

1) Zhou et al. (2017), A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models; Science, 358 1332

AC1903 | TRPC5 blocker is also available in the Cellular Metabolism Library.
CAS:
831234-13-0
Catalog Number:
10-3375
Activity:
TRPC5 blocker
Chemical Name:
1-Benzyl-1H-benzoimidazol-2-yl)-furan-2-ylmethyl-amine
Molecular Weight:
303.36
Molecular Formula:
C19H17N3O
Solubility:
Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 25 mg/ml)
Physical Properties:
Beige solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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