Sodium
Showing all 12 results
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Ion channels
4,9-Anhydrotetrodotoxin | Selective sodium channel blocker
4,9-Anhydrotetrodotoxin (13072-89-4) is a highly selective blocker of the Na(v1.6) sodium channel. (IC50's: Na(v1.2) = 260 nM, Na(v1.3) = 341 nM, N...$125.00 – $995.00 Select options -
Ions and other channels
AA43279 | Nav1.1 activator
AA43279 (354812-16-1) is a selective Nav1.1 activator. In HEK-293 cells expressing human Nav1.1 channels AA43279 increased the Nav1.1-mediated curr...$60.00 – $200.00 Select options -
Ion channels
Benzamil HCl | Sodium channel blocker
Benzamil HCl (2898-76-2) is a derivative of amiloride. Potent sodium channel blocker$50.00 – $175.00 Select options -
Calcium
CGP-37157 | MPTP inhibitor
CGP-37157 (75450-34-9) inhibits the mitochondrial Na+-Ca2+ exchanger (NCX) in isolated heart mitochondria, IC50=0.36 µM.1 Does not inhibit the plas...$80.00 – $325.00 Select options -
BDNF
Deltamethrin | Calcineurin inhibitor; displays neurotrophic activity
Deltamethrin (52918-63-5) is reported to be an inhibitor of calcineurin (PP2B), IC50~100 pM1 but this activity has been disputed2. Markedly enhance...$55.00 – $220.00 Select options -
Approved Drugs
Disopyramide | Antiarrhythmic
Disopyramide (3737-09-5) is a clinically useful sodium channel blocker used as an antiarrhythmic for treatment of ventricular tachycardia1 and hype...$35.00 – $95.00 Select options -
Addiction
GBR-12909 2HCl | Dopamine reuptake inhibitor
GBR-12909 2HCl (67469-78-7) is a potent and selective inhibitor of dopamine reuptake (Ki = 1 nM) with greater than 100 fold selectivity over seroto...$60.00 – $240.00 Select options -
Approved Drugs
Ranolazine | Selective sodium channel blocker
Ranolazine (142387-99-3) is an FDA-approved drug used for the treatment of chronic angina. It inhibits the late inward sodium current in heart musc...$30.00 – $85.00 Select options -
ALS
Riluzole | Sodium channel blocker / Neuroprotective
Riluzole (1744-22-5) is a clinically useful drug for the treatment of amyotrophic lateral sclerosis (ALS).1 Riluzole inhibits glutamate release via...$38.00 – $140.00 Select options -
Approved Drugs
Rufinamide | Anticonvulsant / Improves cognition
Rufinamide (106308-44-5) is a clinically useful anticonvulsant medication.1 Its mechanism of action is believed to be inhibition of Nav1.1 and Nav1...$25.00 – $85.00 Select options -
Ion channels
Veratridine | Na channel opener
Veratridine (71-62-5) is a steroidal alkaloid voltage-gated Na+ channel activator1. Veratridine may be used to increase Na+ concentration in cardio...$50.00 – $200.00 Select options -
Cyclic Nucleotides
Vinpocetine | PDE1 inhibitor
Vinpocetine (42971-09-5) is a phosphodiesterase PDE1 inhibitor (IC50=21 μM).1 Also blocks voltage-gated Na+ channels, IC50=44.2 μM (potency similar...$30.00 – $65.00 Select options
