TRP

Showing 1–12 of 22 results

  • Ion channels

    2-APB | TRP activator

    Rated 0 out of 5
    2-APB (524-95-8) is an IP3 receptor antagonist (IC50=42 μM).1 Inhibits store-operated Ca2+ channels at high concentrations (50 μM) but stimulates a...
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  • Ion channels

    A-967079 | TRPA1 blocker

    Rated 0 out of 5
    A-967079 (1170613-55-4) is a TRPA1 antagonist. Active in rat models.1 Cell permeable References/Citations 1) McGaraughty et al. (2010), TRPA1 m...
    $78.00$312.00 Select options

  • Ions and other channels

    AC1903 | TRPC5 blocker

    Rated 0 out of 5
    AC1903 (831234-13-0) is a potent and selective TRPC5 blocker. Suppresses severe proteinuria and prevents podocyte loss in a transgenic rat model of...
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  • Ion channels

    AP-18 | TRPA1 blocker

    Rated 0 out of 5
    AP-18 (55224-94-7) is a selective TRPA1 (transient receptor potential A1) channel blocker (IC50 = 3.1 and 4.5 μM at human and mouse TRPA1 respectiv...
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  • Ion channels

    BCTC | TRPV1 blocker

    Rated 0 out of 5
    BCTC (393514-24-4) is a vanilloid receptor I (TRPV1) antagonist, IC50 = 35 nM for capsaicin-induced and 6 nM for acid-induced TRPV1 activation. Dis...
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  • Inflammation

    Capsaicin (natural) | TRPV1 agonist

    Rated 0 out of 5
    Capsaicin (404-86-4) is a vanilloid agonist known to activate the transient receptor potential channel vanilloid subfamily member 1 (TRPV1)1,2 and ...
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  • Inflammation

    Evodiamine | TRPV1 agonist, anti-inflammatory, antiangiogenic

    Rated 0 out of 5
    Evodiamine (518-17-2) is a quinolone alkaloid isolated from Evodia rutaecarpa.1 Evodia Rutaecarpa is a very popular herb used in traditional chines...
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  • Ion channels

    GSK-1016790A | TRPV4 channel blocker

    Rated 0 out of 5
    GSK-1016790A (942206-85-1) is a novel and potent TRPV4 channel agonist. GSK-1016790A induced Ca2+ influx in mouse and human TRPV4 expressing HEK ce...
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  • Ions and other channels

    GSK1702934A | TRPC 3/6 activator

    Rated 0 out of 5
    GSK1702934A is a TRPC3 activator.  In whole-cell patch-clamp experiments in HEK293 cells transduced with recombinant human TRPC3 or TRPC6, GSK-1702...
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  • Ion channels

    GSK417651A | TRPC3/6 blocker

    Rated 0 out of 5
    GSK417651A is a TRPC inhibitor. In whole-cell patch-clamp experiments in HEK293 cells transfected with recombinant human TRPC3 or TRPC6, GSK417651A...
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  • Ion channels

    HC-030031 | TRPA1 blocker

    Rated 0 out of 5
    HC-030031 (349085-38-7) inhibits TRPA1 channel. References/Citations 1) McNamara et al. (2007), TRPA1 mediates formalin-induced pain; Proc. Nat...
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  • Ion channels

    HC-067047 | TRPV4 blocker

    Rated 0 out of 5
    HC-067047 (883031-03-6) is a potent reversible and selective TRPV4 antagonist. Active at mouse, human and rat TRPV4, IC50 = 17, 48 and 133 nM respe...
    $58.00$230.00 Select options