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JIB-04 | pan-JUMONJI histone deacetylase inhibitor

JIB-04 (199596-05-9) is a novel specific inhibitor of the Jumonji family of histone demethylases in vitro, in cancer cells and in tumors in vivo. IC50 = 230, 340, 435, 445, 855 and 1100 nM for JARID1A, JMJD2E, JMJD2B, JMJD2A, JMJD3 and JMJD2C respectively.  Reduces tumor burden and prolongs life in a mouse model.1 Suppresses translation initiation and enhances mTOR inhibitor sensitivity.2 Inhibits the growth of temozolomide-resistant glioblastoma cells and crosses the blood brain barrier.3

References/Citations

1) Wang et al. (2013), A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth; Nature Commun., 4 2035
2) Rechem et al. (2015), Lysine demethylase KDM4A associates with translocation machinery and regulates protein synthesis; Cancer Discov., 5 255
3) Banelli et al. (2017), Small molecules targeting histone demethylase genes (KDMs) inhibit growth of temozolomide-resistant glioblastoma cells; Oncotarget, 8 34896

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Focus Biomolecules supplier, chemical structure of JIB-04 | pan-JUMONJI histone deacetylase inhibitor | CAS 199596-05-9

Catalog#  10-1618-0005

$60.00
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CAS:
199596-05-9
Catalog Number:
10-1618
Activity:
pan-JUMONJI histone deacetylase inhibitor
Chemical Name:
(E)-5-Chloro-2-(2-(phenyl(pyridine-2-yl)methylene)hydrazinyl)pyridine
Molecular Weight:
308.76
Molecular Formula:
C17H13ClN4
Solubility:
Soluble in DMSO (up to 30 mg/ml)
Physical Properties:
Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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