Kinases
ALK Cell cycle/cell division DNA damage response ERK Growth factor GSK-3b HER2 Highly selective inhibitors Immunoregulatory JAK JNK Metabolic mTOR Multikinase p38 pan-kinase PI3K PKC RAF SRC Other kinases VEGFR CDK PDGFR
Showing 1–12 of 238 results
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Autophagy
3-Methyladenine | Autophagosome inhibitor
3-Methyladenine (5142-23-4) inhibits autophagy by blocking autophagosome formation via inhibition of type III phosphatidylinositol 3-kinases (PI-3K...$30.00 – $90.00 Select options -
Cardiovascular
6BIO | GSK-3 inhibitor
6BIO (667463-62-9) is a potent and selective inhibitor of glycogen synthase kinase-3 (GSK-3) IC50=5 nM.1 The first pharmacological agent shown to m...$65.00 – $260.00 Select options -
Cell Death
7-Cl-O-Nec1 | RIP1 inhibitor
7-Cl-O-Nec1 (852391-15-2) is a necrostatin-1 (Cat.# 10-1162) analogue with superior potency (IC50 = 206nM vs 494nM), selectivity and metabolic stab...$50.00 – $185.00 Select options -
Kinases
7,8-Dihydroxyflavone | TrkB agonist/neurotrophic
7,8-Dihydroxyflavone (38183-03-8) is a selective TrkB agonist (Kd=320 nM) with potent neurotrophic activity.1,2 Significantly improves motor defic...$45.00 – $150.00 Select options -
ALK
A 83-01 | ALK inhibitor
A 83-01 (909910-43-6) is a potent and selective ALK4, 5 and 7 inhibitor.1,2 IC50 = 45, 12 and 7.5 nM respectively. Prevents phosphorylation of Smad...$50.00 – $200.00 Select options -
Adipogenesis
A-769662 | AMPK activator
A-769662 (844499-71-4) is a potent and reversible AMP-activated protein kinase (AMPK) allosteric activator. Activates AMPK by binding to the β and...$72.00 – $250.00 Select options -
Angiogenesis
AAL-993 | VEGFR inhibitor
AAL-993 (269390-77-4) inhibits VEGFR-1 (IC50 = 130 nM), VEGFR-2 (IC50 = 23 nM), and VEGFR-3 (IC50 = 18 nM). PDGFR-β, cKit, and CSF-1R are also inhi...$75.00 – $300.00 Select options -
Approved Drugs
Abemaciclib | Potent and selective CDK 4/6 inhibitor
Abemaciclib (1231930-82-7) is a potent and selective CDK4/6 inhibitor (IC50 = 2 nM and 10 nM respectively).1 It caused G1 cell cycle arrest in colo...$50.00 – $115.00 Select options -
New Products
Acalabrutinib | Highly selective BTK inhibitor
Acalabrutinib (1420477-60-6) is a highly selective, potent (IC50 = 3 nM), and irreversible inhibitor of Bruton’s tyrosine kinase (BTK).1 Improved t...$45.00 – $145.00 Select options -
New Products
Adavosertib | Wee1 kinase inhibitor
Adavosertib (955365-80-7) inhibits Wee1 tyrosine kinase (IC50 = 5.2 nM) thus preventing phosphorylation of CDC2 and abrogating the G2 DNA damage ch...$45.00 – $155.00 Select options -
Approved Drugs
Afatinib | EGFR and HER2 inhibitor
Afatinib (850140-72-6) is a clinically useful kinase inhibitor approved for the treatment of non-small cell lung cancer. It is a potent and highly ...$55.00 – $140.00 Select options -
Cancer
AG 1478 | EGFR kinase inhibitor
AG-1478 (175478-82-2; base) is a potent and selective inhibitor of the EGFR kinase (IC50 = 3 nM). Inhibits proliferation of a variety human cancer ...$50.00 – $150.00 Select options
