GF-109203X | PKC inhibitor

GF-109203X (133052-90-1) is a potent and selective protein kinase C inhibitor (IC50 = 10 nM; cAMP-dependent protein kinase IC50 = 2 μM and phosphorylase kinase IC50 = 0.7 μM). Inactive against the tyrosine kinases EGFR, PGDFR and Insulin receptor. Potent inhibitor of GSK-3β in cell lysates (IC50 = 360nM) and GSK-3β immunoprecipitates (IC50 = 170nM) derived from rat epididymal adipocytes.2 Cell permeable.

References/Citations
1) Toullec, et al. (1991), The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C; J. Biol .Chem. 266 15771
2) Hers, et al. (1999) The protein kinase C inhibitors bisindolylmaleimide I (GF 109203x) and IX (Ro 31-8220) are potent inhibitors of glycogen synthase kinase-3 activity; FEBS Lett. 460 433

Weight 0.01 mg
Dimensions 0.01 × 0.01 × 0.01 cm
Size:

5 mg, 25 mg

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CAS:
133052-90-1
Catalog Number:
10-1026
Activity:
PKC inhibitor
Alternate Names:
Go 6850; Bisindolylmaleimide I
Chemical Name:
2-[1-(3-Dimethylaminopropyl)indol-3-yl]-3-(indol-3-yl) maleimide
Molecular Weight:
412.49
Molecular Formula:
C25H24N4O2
Solubility:
Soluble in DMSO (up to 10 mg/ml).
Physical Properties:
Orange solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 6 months.
Shipping Code:
RT

GF-109203X | PKC inhibitor

$60.00$240.00

CAS:
133052-90-1
Catalog Number:
10-1026
Activity:
PKC inhibitor
Alternate Names:
Go 6850; Bisindolylmaleimide I
Chemical Name:
2-[1-(3-Dimethylaminopropyl)indol-3-yl]-3-(indol-3-yl) maleimide
Molecular Weight:
412.49
Molecular Formula:
C25H24N4O2
Solubility:
Soluble in DMSO (up to 10 mg/ml).
Physical Properties:
Orange solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 6 months.
Shipping Code:
RT
  • 5 mg
  • 25 mg
Clear
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