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PKC-412 | Protein kinase inhibitor (pan-specific)

CAS:
120685-11-2
Catalog Number:
10-1105
Activity:
Protein kinase inhibitor (pan-specific.)
Alternate Names:
Midostaurin, CGP-41251
Chemical Name:
4′-N-Benzoylstaurosporine
Molecular Weight:
570.65
Molecular Formula:
C35H30N4O4
Solubility:
Soluble in DMSO (up to 15 mg/ml) or in Ethanol (up to 2 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Shipping Code:
RT

PKC-412 (120685-11-2) is a broad spectrum kinase inhibitor. Inhibited kinases include, but are not limited to; PKA, PKC, S6 Kinase, KDR, PKC, Akt, EGFR, VEGFR, PDGFR, c-kit, and FLT-3. Acute myeloid leukemia related mutant forms of FLT-3 are also inhibited both in vitro and in vivo. PKC-412 has been demonstrated to induce apoptosis and shows broad antiproliferative activity in various tumor cell lines. Cell Permeable

References/Citations:

1) Odgerel et al. (2008) The FLT3 inhibitor PKC412 exerts differential cell cycle effects on leukemic cells depending on the presence of FLT3 mutations; Oncogene, 27 3102
2) El Fitori et al. (2007) PKC 412 small-molecule tyrosine kinase inhibitor: single-compound therapy for pancreatic cancer; Cancer, 110 1457
3) Miyatake, et al. ( 2007) PKC412 (CGP41251) modulates the proliferation and lipopolysaccharide-induced inflammatory responses of RAW 264.macrophages; Biochem. Biophys. Res. Commun., 360 115
4) Bahlis et.al. (2005) N-Benzoylstaurosporine (PKC412) inhibits Akt kinase inducing apoptosis in multiple myeloma cells; Leuk. Lymphoma, 46 899
5) Fabbro et al., (2000) PKC-412 – a protein kinase inhibitor with a broad therapeutic potential; Anticancer Drug Des., 15 17

 

PKC-412 | Protein kinase inhibitor (pan-specific) is also available in the Cellular Metabolism Library.
CAS:
120685-11-2
Catalog Number:
10-1105
Activity:
Protein kinase inhibitor (pan-specific.)
Alternate Names:
Midostaurin, CGP-41251
Chemical Name:
4′-N-Benzoylstaurosporine
Molecular Weight:
570.65
Molecular Formula:
C35H30N4O4
Solubility:
Soluble in DMSO (up to 15 mg/ml) or in Ethanol (up to 2 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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