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RepSox | TGFß type I / ALK5 inhibitor

CAS:
446859-33-2
Catalog Number:
10-4546
Activity:
TGFß type I/ALK5 inhibitor
Chemical Names:
2-(3-(6-Methylpyridine-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine; E-616452; SNJ 2511
Molecular Weight:
287.32
Molecular Formula:
C17H13N5
Solubility:
Soluble in DMSO (>25 mg/ml); ethanol (10 mg/ml)
Physical Properties:
Pale yellow solid
Purity:
99% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

RepSox (446859-33-2) is a potent (IC50 ALK5 auto-P= 4 nM; IC50 TGF-β cellular assay = 23 nM) inhibitor of the TGF-β type I receptor (ALK5).1 RepSox can replace Sox2 in reprogramming adult cells into pluripotent stem cells via induction of Nanog transcription.2 It was able to convert astrocytes into neuronal cells as part of a small molecule cocktail (along with valproic acid and CHIR99021).3,4

References/Citations:

1) Gellibert et al. (2004), Identification of 1,5-Naphthyridine Derivatives as a Novel Series of Potent and Selective TGF-β Type I Receptor Inhibitors; J. Med. Chem. 47 4494
2) Ichida et al. (2009), A Small-molecule Inhibitor of TGF-β Signaling Replaces Sox2 in Reprogramming by Inducing Nanog; Cell Stem Cell 5 491
3) Cheng et al. (2015), Direct Conversion of astrocytes into neuronal cells by a drug cocktail; Cell Res. 25 1269
4) Cheng et al. (2014), Generation of neural progenitor cells by chemical cocktails and hypoxia; Cell Res. 24 665

RepSox | TGFß type I / ALK5 inhibitor is also available in the Cellular Metabolism Library.
CAS:
446859-33-2
Catalog Number:
10-4546
Activity:
TGFß type I/ALK5 inhibitor
Chemical Names:
2-(3-(6-Methylpyridine-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine; E-616452; SNJ 2511
Molecular Weight:
287.32
Molecular Formula:
C17H13N5
Solubility:
Soluble in DMSO (>25 mg/ml); ethanol (10 mg/ml)
Physical Properties:
Pale yellow solid
Purity:
99% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

Product Data Sheet:

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