SB-431542 | ALK4,5 and 7 inhibitor

SB-431542 (301836-41-9) is a potent and selective ALK4, ALK5 and ALK7 inhibitor (TGFβ superfamily Type I activin receptor-like kinase). (ALK5 IC50 = 94 nM).1,2 Inhibits TGFβ-induced proliferation of human osteosarcoma cells.3 Enhances growth and integrity of embryonic stem cell-derived endothelial cells.4 SB-431542 is a frequently used agent employed in numerous stem cell differentiation protocols.5 Cell permeable.

References/Citations
1) Laping et al. (2002), Inhibition of transforming growth factor (TGF-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I kinase activity: SB-431542; Mol. Pharmacol., 62 58
2) Inman et al. (2002), SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5 and ALK7; Mol. Pharmacol., 62 65
3) Matsuyama et al. (2003), SB-431542 and Gleevec inhibit transforming growth factor-beta-induced proliferation of human osteosarcoma cells; Cancer Res., 63 7791
4) Watabe et al. (2003), TGF-beta receptor kinase inhibitor enhances growth and integrity of embryonic stem cell-derived endothelial cells; J. Cell Biol., 163 1303
5) Stanslowsky et al. (2014), Functional differentiation of midbrain neurons from human cord blood-derived induced pluripotent stem cells; Stem Cell Res. Ther., 5 35

Weight 0.01 mg
Dimensions 0.01 × 0.01 × 0.01 cm
Size :

5 mg, 25 mg

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CAS:
301836-41-9
Catalog Number:
10-2443
Activity:
ALK4,5 and 7 inhibitor
Chemical Name:
4-[4-(1,3-Benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide
Molecular Weight:
384.4
Molecular Formula:
C22H16N4O3
Solubility:
Soluble in DMSO (up to 30 mg/ml), or in Ethanol (up to 3 mg/ml).
Physical Properties:
Yellow solid
Purity:
99% by HPLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT

SB-431542 | ALK4,5 and 7 inhibitor

$70.00$220.00

CAS:
301836-41-9
Catalog Number:
10-2443
Activity:
ALK4,5 and 7 inhibitor
Chemical Name:
4-[4-(1,3-Benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide
Molecular Weight:
384.4
Molecular Formula:
C22H16N4O3
Solubility:
Soluble in DMSO (up to 30 mg/ml), or in Ethanol (up to 3 mg/ml).
Physical Properties:
Yellow solid
Purity:
99% by HPLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT
  • 5 mg
  • 25 mg
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