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The phosphorylation state of a biologically relevant molecule affects its activity, reactivity, and ability to interact with other molecules. The enzymes responsible for adding phosphate groups, kinases, act on many types of molecules including proteins, lipids, carbohydrates, and nucleotides. These kinases mediate multiple signal transduction pathways and are responsible for modulating many essential cellular functions including metabolism, proliferation, differentiation, and survival. Dysfunction of kinases is involved in many pathological states including cancer, neurodegeneration, inflammation, metabolic and developmental disorders, and autoimmune diseases.
Immuno-Regulatory
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AXL inhibitor that suppresses myeloid cell activation
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Dual inhibitor of CSF1R and c-KIT; Inhibits suppression of antitumor immunity
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TGF-β kinase inhibitor that reverses TGF-β and Treg mediated T cell suppression
Metabolic
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PFK15 is a phosphofructo-2-kinase (PFKFB3) inhibitor. Antagonizes glucose and F26BP uptake
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GSK2334470 is a potent and selective PDK1 inhibitor.
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DNA protein kinase inhibitor
Cell Cycle / Cell Division
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Clinically useful inhibitor of CDK4/6
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RO-3306 is a selective inhibitor of CDK1
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Alisertib is a potent and selective inhibitor of Aurora A kinase
Growth Factor
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Potent and highly selective inhibitor of EGFR and HER2
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NVP-BGJ398 is a potent and selective-pan FGFR inhibitor
DNA Damage Response
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KU-55933 is a potent and selective ATM kinase inhibitor
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DNA protein kinase inhibitor
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Potent and selective ATR kinase inhibitor
Protein Kinase C
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Enzastaurin is a potent and selective PKCβ inhibitor
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PKC activator
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Protein kinase C inhibitor which interacts with the C1 domain of PKC
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