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ALK

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of A83-01 | ALK inhibitor | CAS 909910-43-6
    $48.00
    A83-01 (909910-43-6) is a potent and selective ALK4, 5 and 7 inhibitor.1,2 IC50 = 45, 12 and 7.5 nM respectively. Prevents phosphorylation of Smad2/3 and growth inhibition induced by TGFβ.2 Inhibits...

  • Focus Biomolecules cell signaling supplier, chemical structure of Crizotinib | c-MET and ALK inhibitor | CAS 877399-52-5
    $80.00
    Crizotinib (877399-52-5) is a potent and selective inhibitor of c-MET and ALK, IC50's=8 and 20 nM respectively.1 Inhibition of cell proliferation was associated with G1-S phase cell cycle arrest and induction of...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure Dorsomorphin | AMPK inhibitor | CAS 866405-64-3
    $60.00
    Dorsomorphin (866405-64-3) is a potent, selective and ATP-competitive inhibitor of AMP-activated protein kinase (AMPK) (Ki = 109 nM).1 It displays no significant inhibition of ZAPK, SYK, PKCT, PKA and JAK3. It inhibits bone...

  • Galunisertib | Potent TGFB receptor 1 inhibitor / Cancer immunotherapeutic
    $50.00
    Galunisertib (700874-72-2) is a TGF-β kinase (ALK5) antagonist.1 It stimulated hematopoiesis from primary myelodysplastic syndrome bone marrow specimens via downregulation of SMAD2 phosphorylation.2 It has been in...

  • Focus Biomolecules cell signaling supplier, chemical structure of LDN-193189 | ALK2 &  ALK3 inhibitor | CAS 1062368-62-0
    $70.00
    LDN-193189 HCl (1062368-62-0) is a potent and selective inhibitor of ALK2 (IC50 = 5 nM) and ALK3 (IC50 = 30 nM), thereby inhibiting SMAD1/5/8 phosphorylation.1  Only weak inhibition of ALK4, ALK5, and ALK7 is observed...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of LY-364947 | ALK5 inhibitor | CAS 396129-53-6
    $74.00
    LY-364947 (396129-53-6) is a selective ALK5 inhibitor, IC50 = 59, 400 and 1400 nM for TGF-β RI, TGF-β RII and MLK-7K, respectively1. Inhibits Smad2 phosphorylation induced by TGF-β as well as fibronectin...

  • Focus Biomolecules cell signaling supplier, chemical structure of RepSox | TGFbetaR-1 | ALK5 inhibitor | CAS 446859-33-2
    $65.00
    RepSox (446859-33-2) is a potent (IC50 ALK5 auto-P= 4 nM; IC50 TGF-β cellular assay = 23 nM) inhibitor of the TGF-β type I receptor (ALK5).1 RepSox can replace Sox2 in reprogramming adult cells into pluripotent...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure SB-431542 | ALK4,5 and 7 inhibitor | CAS 301836-41-9
    $70.00
    SB-431542 (301836-41-9) is a potent and selective ALK4, ALK5 and ALK7 inhibitor (TGFβ superfamily Type I activin receptor-like kinase). (ALK5 IC50 = 94 nM)1,2. Inhibits TGFβ-induced proliferation of human...

  • Focus Biomolecules cell signaling supplier, chemical structure of SB-525334 | ALK5 (TGFbeta R1) inhibitor | CAS 356559-20-1
    $60.00
    SB-525334 (356559-20-1) is a potent and selective inhibitor of the transforming growth factor beta 1 receptor, activin receptor-like kinase (ALK5) (IC50 = 14.3 nM) and ALK4, (IC50 = 58.5 nM) with no activity at ALK2, 3 and 6...

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