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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of BML-259 | CDK5/p25 inhibitor | CAS 267254-00-2
    BML-259 (267654-00-2) is a potent inhibitor of Cdk5/p25 (IC50 = 64 nM) and Cdk2 (IC50 = 98nM).1 References/Citations1) Helal et al. (2004) Discovery and SAR of 2-aminothiazole inhibitors of cyclin-dependent kinase 5/p25 as a...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Fascaplysin | CDK4 inhibitor | CAS 114718-57-2
    Fascaplysin (114719-57-2) is a novel marine natural product isolated from Thorectandra sp.1 A potent and selective inhibitor of cyclin dependent kinase 4/cyclin D1 (IC50 = 0.35 μM) and is less selective for Cdk6/D1...

  • Flavopiridol HCl | CDK inhibitor
    Flavopiridol HCl (131740-09-5) is a cyclin-dependent kinase (CDK) inhibitor that causes cell cycle arrest at G1 and G2 phase.1 Potentiates (100-200 nM) PMA-induced apoptosis in HL-60 and U937 cells.2 Potentiates the effects...

  • Focus Biomolecules supplier, chemical structure of Indirubin-3'-monoxime | GSK-3 beta and CDK inhibitor | CAS 160807-49-8
    Indirubin-3'-monoxime (160807-49-8) is a potent GSK-3β inhibitor (IC50=22 nM)1. Also inhibits CDK1 (IC50=180 nM) and CDK5 (IC50=100 nM)1. Displays antimitotic properties and induces endoreplication following prophase...

  • Purvalanol A | CDK inhibitor
    Purvalanol A (212844-53-6) is a cyclin-dependent kinase inhibitor. IC50s= 4, 70, 35, 75 and 850 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk5/p35 and cdk4/cyclin D1 and respectively.1 Reversibly arrests...

  • Ribociclib | CDK4/6 inhibitor
    Ribociclib (1211441-98-3) is a clinically useful, potent, and specific CDK4/6 inhibitor.1,2,3  It was recently approved for use in HR+, HER2- metastatic breast cancer. References/Citations 1) Rader et al. (2013), Dual...

  • RO-3306 | Selective CDK1 inhibitor
    RO-3306 is a selective inhibitor of CDK1 (IC50 = 35 nM versus CDK2 IC50 = 340nM).1,2 It induces G2/M phase cell cycle arrest and apoptosis. Inhibition of CDK1 with RO-3306 has been shown to have synergistic effects with PARP...

  • Focus Biomolecules cell signaling reagent supplier, structure of Roscovitine | p34/cdc2 inhibitor | CAS 186692-46-6
    Roscovitine (186692-46-6) is a potent and selective inhibitor of cyclin-dependent kinases displaying higher potency and selectivity compared to olomoucine.  p34 cdc2 IC50 = 0.2 µM.  Also inhibits p33cdk2 and...

  • THZ1 | Potent and selective CDK7 inhibitor
    THZ1 (1604810-83-4) is an irreversible, covalent inhibitor (dual ATP-site and allosteric covalent binding) of CDK7 (IC50 = 15.6nM @ 20min and 3.2nM @ 180 min).1 It displayed broad based antiproliferative activity with...

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