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EGFR

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  • Focus Biomolecules cell signaling supplier, chemical structure of Afatinib | EGFR, HER2 inhibitor | CAS 850140-72-6
    $85.00
    Afatinib (850140-72-6) is a clinically useful kinase inhibitor approved for the treatment of non-small cell lung cancer. It is a potent and highly selective inhibitor of mutant and wild-type EGFR (IC50= 0.5 nM) and HER2...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of AG 1478 | EGFR kinase inhibitor | CAS 175178-82-2
    $50.00
    AG-1478 (175478-82-2; base) is a potent and selective inhibitor of the EGFR kinase (IC50 = 3 nM). Inhibits proliferation of a variety human cancer cell lines1,2. AG-1478 reduces pulmonary fibrosis in a rat model3. Cell...

  • Focus Biomolecules cell signaling reagent supplier, structure of AG-1296 | PDGFR kinase inhibitor | CAS 146535-11-7
    $60.00
    AG-1296 (146535-11-7) is a potent inhibitor of PDGF receptor kinase (IC50 = 1 μM), c-kit and FGF kinase. Induces apoptosis in H526, small-cell lung cancer cells. References/Citations1) Kovalenko et al. (1997),...

  • Focus Biomolecules supplier, chemical structure of AG-1517 HCl | Tyrosine kinase inhibitor | CAS 153436-54-5
    $70.00
    AG-1517 HCl (153436-54-5) is an ultra-potent inhibitor of epidermal growth factor receptor tyrosine kinase (EGFR), with an IC50 of 25 pM. Inhibits other tyrosine kinases at micromolar or higher concentrations. It selectively...

  • Focus Biomolecules cell signaling supplier, chemical structure of CUDC-101 | Dual HDAC & EGFR inhibitor | CAS 1012054-59-9
    $70.00
    CUDC-101 (CAS 1012054-59-9) is a novel hybrid dual-acting HDAC and receptor tyrosine kinase inhibitor. It is a potent HDAC inhibitor which also inhibits EGFR and HER2,  IC50 = 4.4, 2.4 and 15.7 nM respectively.1 It not...

  • ERGi-USU | Highly Selective ERG Inhibitor
    $35.00
    ERGi-USU (1147-56-4) selectively inhibits the growth of ERG-positive VCaP prostate cancer cells, COLO320 colon cancer cells, KG-1 and MOLT-4 leukemia cells with minimal effect on ERG-negative cells or normal prostate or...

  • Focus Biomolecules cell signaling reagent supplier, structure of Gefitinib | EGFR kinase inhibitor | CAS 184475-35-2
    $30.00
    Gefitinib (184475-35-2) is a potent and selective EGFR kinase inhibitor (IC50 = 23-79 nM)1. Inhibits EGFR autophosphorylation and inhibits tumor growth in vivo2. Enhances efficacy of cytotoxic agents3. Inhibits growth factor...

  • Focus Biomolecules cell signaling supplier, chemical structure of Lapatinib (base) | EGFR & HER2 inhibitor | CAS 231277-92-2
    $50.00
    Lapatinib (231277-92-2) is a potent inhibitor of EGFR kinase (Ki=3 nM), Erb-2 kinase (Ki=13 nM) Erb-4 kinase (Ki=347 nM).1  Clinically useful agent for treatment of breast cancer.2-3 Cell...

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