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Highly selective inhibitors

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  • Acalabrutinib | Highly selective BTK inhibitor
    $45.00
    Acalabrutinib (1420477-60-6) is a highly selective, potent (IC50 = 3nM), and irreversible inhibitor of Bruton’s tyrosine kinase (BTK).1 Improved target selectivity (especially against TEC family kinases and EGFR)...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Alisertib | Aurora A inhibitor | CAS 1028486-01-2
    $60.00
    Alisertib (MLN8237, 1028486-01-2) is a highly selective and potent (IC50 = 1 nM) cell permeable inhibitor of Aurora A with off-target binding at GABAA (IC50 = 490 nM).1 It disrupts the Aurora A-Myc complex leading to Myc...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of AZD6244 | ERK inhibitor | CAS 606143-53-6
    $75.00
    AZD6244 (606143-53-6) is a potent, selective, and non-ATP competitive inhibitor of MEK1/2 (IC50 MEK1 = 14 nM) and ERK 1/2 phosphorylation (IC50 = 10 nM).1,2 AZD6244 is in clinical trials for treating various cancers.3-7...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of AZD8055 | mTOR kinase inhibitor | CAS 1009298-09-2
    $45.00
    AZD8055 (1009298-09-2) is a potent and highly selective inhibitor of mammalian target of rapamycin kinase (mTOR) kinase (IC50 = 0.8 nM).1,2  mTOR acts as a nutrient/energy/redox sensor and a controller of protein...

  • Binimetinib | MEK1/2 inhibitor
    $39.00
    Binimetinib (606143-89-9) is a potent (IC50 = 12 nM) and selective allosteric inhibitor of MEK1/2.1,2 Recently approved by the FDA for treatment of melanoma in combination with Encorafenib. Binimetinib has had limited...

  • Duvelisib | PI3Kdelta/gamma inhibitor
    $75.00
    Duvelisib (1201438-56-3) is a potent and selective (IC50’s: PI3Kα = 1602nM, PI3Kβ = 85nM, PI3Kδ= 2.5nM, PI3Kγ = 27nM) dual PI3Kδ/γ inhibitor.1 It inhibits B and T cell proliferation,...

  • GSK2334470 | Potent and selective PDK1 inhibitor
    $59.00
    GSK2334470 (1227911-45-6) is a potent (IC50 = 10 nM) and selective inhibitor of 3-Phosphoinositide-dependent kinase 1 (PDK1), which phosphorylates and activates a group of protein kinases in the AGC/PKG/PKC family.1 It...

  • Focus Biomolecules cell signaling reagent supplier, structure of Imatinib mesylate | BCR-ABL inhibitor | CAS 220127-57-1
    $30.00
    Imatinib (220127-57-1) is a tyrosine kinase inhibitor specific for abl (IC50 = 0.038 μM)1, PDGF-R (IC50 = 0.3 μM)1 and c-kit (IC50 = 0.1 μM)2. It is a clinically useful anti-cancer drug approved for the treatment of...

  • IntelliScreen Highly Selective Kinase Inhibitor Library 1 plate 100 ul/well
  • Focus Biomolecules supplier, chemical structure of Linsitinib | Inhibits IGF-1R kinase & InsR kinase | CAS 867460-71-2
    $60.00
    Linsitinib (867460-71-2) is a potent and selective dual inhibitor of insulin-like growth factor 1 (IGF-1R) kinase and insulin receptor (InsR) kinase (IC50’s = 35 and 75 nM respectively).1  It has been investigated...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of MK-2206 | Akt inhibitor | CAS 1032350-13-2
    $70.00
    MK-2206 (CAS 1032350-13-2) is a potent and selective allosteric inhibitor of Akt (IC50’s: Akt1 = 5 nM, Akt2 = 12 nM, Akt3 = 65 nM) that enhances the in vitro and in vivo antitumor efficacy of several standard...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of ML167 | Clk4 inhibitor | CAS 1285702-20-6
    $75.00
    ML167 (1285702-20-6) is a highly selective cell permeable inhibitor of Cdc2-like kinase 4 (Clk4) - IC50 = 136nM. It displays at least 10-fold greater selectivity over the related kinases Clk1(1.52 μM), Clk2(1.65μM),...

  • Focus Biomolecules cell signaling supplier, chemical structure of NVP-BGJ398 | Pan-specific FGFR inhibitor | CAS 87251-34-1
    $65.00
    NVP-BGJ398 (872511-34-1) is a potent and selective pan-FGFR inhibitor (IC50 = 0.9nM, 1.4 nM, 1.0 nM, and 60 nM for FGFR1,2,3,4 respectively).1  It has also been used in a mouse model of Achondroplasia (most common form...

  • Quizartinib | Selective FLT3 Inhibitor
    $50.00
    Quizartinib (950769-58-1) is a potent and selective inhibitor of FLT3 (Kd = 1.6nM, IC50 = 0.56 nM MV4-11 cells).1 It is in clinical trials for treatment of Acute Myelogenous Leukemia (AML).2,3 Quizartinib priming resulted in...

  • R428 | Potent and selective AXL inhibitor
    $120.00
    R428 (1037624-75-1) is a potent and selective inhibitor of AXL kinase (IC50 = 1.4nM).1 R428 has been shown to overcome chemotherapy resistance to various agents in multiple cancer models.2-5 AXL has been shown to...

  • Focus Biomolecules cell signaling reagent supplier, structure of Roscovitine | p34/cdc2 inhibitor | CAS 186692-46-6
    $35.00
    Roscovitine (186692-46-6) is a potent and selective inhibitor of cyclin-dependent kinases displaying higher potency and selectivity compared to olomoucine.  p34 cdc2 IC50 = 0.2 µM.  Also inhibits p33cdk2 and...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Ruxolitinib | JAK inhibitor | CAS 941678-49-5
    $70.00
    Potent and selective JAK1&2 inhibitor, IC50s=2.7, 4.5 and 322 nM forJAK1, JAK2 and JAK3 respectively.1  Blocks IL-6 signaling (IC50=281 nM) and proliferation of JAK2V617F+ Ba/F3 cells (IC50=127 nM).2 Inhibits the...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of SMI-4a | PIM1 inhibitor | CAS 438190-29-5
    $60.00
    SMI-4a (438190-29-5) is a selective, ATP-competitive inhibitor of the Pim protein kinases (IC50 = 24 and 100 nM for Pim-1 and Pim-2 respectively). Selective over a panel of ~50 other kinases.1 Induces cell cycle arrest...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Tofacitinib | JAK inhibitor | CAS 477600-75-2
    $60.00
    Tofacitinib (477600-75-2) is a potent pan-JAK inhibitor, IC50s=1, 20 and 112 nM for JAK3, JAK2 and JAK1 respectively.1 Displays potent antiinflammatory2 and immunosuppressant3 activity. Promotes a white-to-brown metabolic...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Trametinib | MEK inhibitor | CAS 871700-17-3
    $40.00
    Trametinib (871700-17-3) is a highly potent (IC50 uMEK1 = 0.7 nM, pp-MEK1 = 14.9 nM)1 and selective MEK inhibitor displaying selective inhibition of proliferation in various BRAF mutant cancer cell lines (IC50 ACHN = 9.8 nM;...

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