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Highly selective inhibitors

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  • Acalabrutinib | Highly selective BTK inhibitor
    $45.00
    Acalabrutinib (1420477-60-6) is a highly selective, potent (IC50 = 3 nM), and irreversible inhibitor of Bruton’s tyrosine kinase (BTK).1 Improved target selectivity (especially against TEC family kinases and EGFR)...

  • Alectinib | Potent and selective ALK inhibitor
    $60.00
    Alectinib (1256580-46-7) is a potent (IC50 = 1.9 nM) and highly selective ALK inhibitor.1 It blocked phosphorylation of both native ALK and the L1196M, C1156Y, and F1174L mutants. Alectinib has also been shown to inhibit RET...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Alisertib | Aurora A inhibitor | CAS 1028486-01-2
    $60.00
    Alisertib (MLN8237, 1028486-01-2) is a highly selective and potent (IC50 = 1 nM) cell permeable inhibitor of Aurora A with off-target binding at GABAA (IC50 = 490 nM).1 It disrupts the Aurora A-Myc complex leading to Myc...

  • AZ20  | ATR kinase inhibitor
    $60.00
    AZ20 (1233339-22-4) is a potent and highly selective inhibitor of Ataxia telangiectasia mutated and RAD3-related (ATR) kinase (IC50 = 5 nM in vitro; IC50 = 50 nM in HT29 colorectal adenocarcinoma cells).1 Combination therapy...

  • AZD1152-HQPA | Aurora B kinase inhibitor
    $50.00
    AZD1152-HQPA (722544-51-6) is a potent and highly selective inhibitor of Aurora B.1 Aurora B Ki = 0.36 nM; Aurora A Ki = 1,369 nM.2 It inhibits the growth of tumors in multiple cancer models.3-6 Excessive ROS generation7 and...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of AZD6244 | ERK inhibitor | CAS 606143-53-6
    $40.00
    AZD6244 (606143-52-6) is a potent, selective, and non-ATP competitive inhibitor of MEK1/2 (IC50 MEK1 = 14 nM) and ERK 1/2 phosphorylation (IC50 = 10 nM).1,2 AZD6244 is in clinical trials for treating various cancers...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of AZD8055 | mTOR kinase inhibitor | CAS 1009298-09-2
    $45.00
    AZD8055 (1009298-09-2) is a potent and highly selective inhibitor of mammalian target of rapamycin kinase (mTOR) kinase (IC50 = 0.8 nM).1,2  mTOR acts as a nutrient/energy/redox sensor and a controller of protein...

  • Binimetinib | MEK1/2 inhibitor
    $39.00
    Binimetinib (606143-89-9) is a potent (IC50 = 12 nM) and selective allosteric inhibitor of MEK1/2.1,2 Recently approved by the FDA for treatment of melanoma in combination with Encorafenib. Binimetinib has had limited...

  • Duvelisib | PI3Kdelta/gamma inhibitor
    $65.00
    Duvelisib (1201438-56-3) is a potent and selective (IC50’s: PI3Kα = 1602nM, PI3Kβ = 85nM, PI3Kδ= 2.5nM, PI3Kγ = 27nM) dual PI3Kδ/γ inhibitor.1 It inhibits B and T cell proliferation,...

  • Fruquintinib | Potent and selective inhibitor of VEGFR kinase
    $75.00
    Fruquintinib (1194506-26-7) is a potent and highly selective inhibitor of VEGFR kinase (IC50’s: VEGFR1= 33 nM, VEGFR2 = 35 nM, VEGFR3 = 0.5 nM).1 It potently inhibited VEGF/VEGFR signaling and cell proliferation in...

  • GSK2334470 | Potent and selective PDK1 inhibitor
    $59.00
    GSK2334470 (1227911-45-6) is a potent (IC50 = 10 nM) and selective inhibitor of 3-Phosphoinositide-dependent kinase 1 (PDK1), which phosphorylates and activates a group of protein kinases in the AGC/PKG/PKC family.1 It...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of GSK2982772 | RIPK1 inhibitor | CAS
    $95.00
    GSK2982772 (1622848-92-3) is a highly selective inhibitor of Receptor-interacting Protein 1 kinase (RIP1); IC50 = 1.6 nM.1 Novel anti-inflammatory agent previously in clinical trials for psoriasis, rheumatoid arthritis, and...

  • GSK583 | RIP2 kinase inhibitor
    $40.00
    GSK583 (1346547-00-9) is a highly selective and potent inhibitor of RIP2 kinase, IC50 = 5 nM human and IC50 = 2 nM rat.1 It also potently inhibits isolated RIP3 kinase (IC50 = 5 nM) but is inactive against RIP3 in cellular...

  • Focus Biomolecules cell signaling reagent supplier, structure of Imatinib mesylate | BCR-ABL inhibitor | CAS 220127-57-1
    $30.00
    Imatinib (220127-57-1) is a tyrosine kinase inhibitor specific for abl (IC50 = 0.038 μM)1, PDGF-R (IC50 = 0.3 μM)1 and c-kit (IC50 = 0.1 μM)2. It is a clinically useful anti-cancer drug approved for the treatment of...

  • IntelliScreen Highly Selective Kinase Inhibitor Library 1 plate 100 ul/well
  • Ipatasertib | Pan-AKT inhibitor
    $65.00
    Ipatasertib (1001264-89-6) is a selective (against a panel of 230 kinases) and potent pan-Akt inhibitor (IC50s: Akt1 = 5 nM, Akt2 = 18 nM, Akt3 = 8 nM).1 It displayed efficacy in xenograft models of prostate, breast,...

  • Larotrectinib | Potent and selective panTRK inhibitor
    $65.00
    Larotrectinib (1223403-58-4) is a potent (IC50’s < 11 nM) inhibitor of tropomyosin receptor kinases A, B, and C (TrkA, B, and C).1 It is >100 fold selective against a panel of 229 kinases. Larotrectinib markedly...

  • Focus Biomolecules supplier, chemical structure of Linsitinib | Inhibits IGF-1R kinase & InsR kinase | CAS 867460-71-2
    $60.00
    Linsitinib (867160-71-2) is a potent and selective dual inhibitor of insulin-like growth factor 1 (IGF-1R) kinase and insulin receptor (InsR) kinase (IC50’s = 35 and 75 nM respectively).1  It has been investigated...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of MK-2206 | Akt inhibitor | CAS 1032350-13-2
    $55.00
    MK-2206 (CAS 1032350-13-2) is a potent and selective allosteric inhibitor of Akt (IC50’s: Akt1 = 5 nM, Akt2 = 12 nM, Akt3 = 65 nM) that enhances the in vitro and in vivo antitumor efficacy of several standard...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of ML167 | Clk4 inhibitor | CAS 1285702-20-6
    $75.00
    ML167 (1285702-20-6) is a highly selective cell permeable inhibitor of Cdc2-like kinase 4 (Clk4) - IC50 = 136nM. It displays at least 10-fold greater selectivity over the related kinases Clk1(1.52 μM), Clk2(1.65μM),...

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