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  • AG-490 | 133550-30-8 | Structure | Supplier
    AG-490 (133550-30-8) is a potent inhibitor of the JAK-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells, which abundantly express JAK-2, AG-490 dose-dependently blocked cell growth, induced apoptosis and...

  • Lestaurtinib | FLT3/TrkA inhibitor
    Lestaurtinib (111358-88-4) is a potent and selective FLT3 inhibitor (IC50= 2 nM).1,2 Inhibits RET and RET phosphorylation in medullary thyroid carcinoma cells.3 Suppresses JAK2/STAT5 signaling and the proliferation of...

  • NSC-33994 | 82058-16-0 | Structure | Supplier
    NSC-33994 (82058-16-0) is a remarkably potent and selective JAK2 inhibitor (IC50 = 60 nM). Displays no effect on Src and TYK2 tyrosine kinase activity at a concentration of 25 μM1. Suppresses JAK2-V617F-mediated human...

  • Ruxolitinib | JAK inhibitor
    Potent and selective JAK1&2 inhibitor, IC50s=2.7, 4.5 and 322 nM forJAK1, JAK2 and JAK3 respectively.1  Blocks IL-6 signaling (IC50=281 nM) and proliferation of JAK2V617F+ Ba/F3 cells (IC50=127 nM).2 Inhibits the...

  • Tofacitinib | JAK inhibitor
    Tofacitinib (477600-75-2) is a potent pan-JAK inhibitor, IC50s=1, 20 and 112 nM for JAK3, JAK2 and JAK1 respectively.1 Displays potent antiinflammatory2 and immunosuppressant3 activity. Promotes a white-to-brown metabolic...

  • WHI-P131 | 202475-60-3 | Structure | Supplier
    WHI-P131 (202475-60-3) is a JAK3 inhibitor. Inhibits human glioblastoma cell adhesion and invasion1. Increases survival in a mouse ALS model2. References/Citations1) Narla et al. (1998), Inhibition of human glioblastoma...

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