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  • Focus Biomolecules cell signaling tech supplier, structure 7,8-Dihydroxyflavone | TrkB agonist/neurotrophic | CAS 38183-03-8
    $45.00
    7,8-Dihydroxyflavone (38183-03-8) is a selective TrkB agonist (Kd=320 nM) with potent neurotrophic activity.1,2  Significantly improves motor deficits, ameliorates brain atrophy and extends survival in the...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of 7-Cl-O-Nec1 | RIP1 inhibitor | CAS 852391-15-2
    $50.00
    7-Cl-O-Nec1 (852391-15-2) is a necrostatin-1 (Cat.# 10-1162) analogue with superior potency (IC50 = 206nM vs 494nM), selectivity and metabolic stability in blocking RIP1.1,2 7-Cl-O-Nec1 shows no off-target inhibition of...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of A-769662 | AMPK activator | CAS 844499-71-4
    $72.00
    A-769662 (844499-71-4) is a potent and reversible AMP-activated protein kinase (AMPK) allosteric activator.  Activates AMPK by binding to the β and γ subunits and not the AMP binding site.1 EC50=0.8 mM for...

  • Focus Biomolecules cell signaling reagent supplier, structure of AG-1296 | PDGFR kinase inhibitor | CAS 146535-11-7
    $60.00
    AG-1296 (146535-11-7) is a potent inhibitor of PDGF receptor kinase (IC50 = 1 μM), c-kit and FGF kinase. Induces apoptosis in H526, small-cell lung cancer cells. References/Citations1) Kovalenko et al. (1997),...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Alisertib | Aurora A inhibitor | CAS 1028486-01-2
    $60.00
    Alisertib (MLN8237, 1028486-01-2) is a highly selective and potent (IC50 = 1 nM) cell permeable inhibitor of Aurora A with off-target binding at GABAA (IC50 = 490 nM).1 It disrupts the Aurora A-Myc complex leading to Myc...

  • Focus Biomolecules supplier, chemical structure of Amlexanox | TBK1 inhibitor / Antidiabetic | CAS 68302-57-8
    $40.00
    Amlexanox (68302-57-8) improves obesity-related metabolic dysfunction in mouse models.1 Increases thermogenesis and weight loss, decreases steatosis and improves insulin sensitivity.  Inhibits TANK-binding kinase 1...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of ANA-12 | TrkB antagonist | CAS 219766-25-3
    $75.00
    ANA-12 (219755-25-3) is a TrkB receptor antagonist. Binds to two distinct receptor sites preventing activation by BDNF non-competitively, IC50 = 45.6 nM and 41.1 μM for the high and low affinity sites respectively...

  • BI-D1870 | p90 ribosomal S6 kinase inhibitor
    $90.00
    BI-D1870 (501437-28-1) is an inhibitor of p90 ribosomal S6 kinase (RSK; IC50’s = RSK1, 31 nM; RSK2, 24 nM; RSK3, 18 nM; RSK4, 15 nM) with selectivity over other AGC kinases.1 It protected mice from experimental...

  • Binimetinib | MEK1/2 inhibitor
    $39.00
    Binimetinib (606143-89-9) is a potent (IC50 = 12 nM) and selective allosteric inhibitor of MEK1/2.1,2 Recently approved by the FDA for treatment of melanoma in combination with Encorafenib. Binimetinib has had limited...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of BML-277 | CHK2 inhibitor | CAS 516480-79-8
    $90.00
    BML-277 (516480-79-8) is a potent selective inhibitor of Chk2 (IC50 = 15 nM). BML-277 has been screened against a panel of 35 kinases, and shows less that 25% inhibition of any other kinase at 10 μM, demonstrating the...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of BML283 | PKM2 activator | CAS 562867-96-3
    $45.00
    BML283 (562867-96-3) is a selective activator of the Tumor Specific M2 Isoform of Pyruvate Kinase (PKM2) - AC50 = 111nM.1 PKM2 activity is downregulated in most cancer cells leading to a decrease in catabolic metabolism and...

  • Focus Biomolecules supplier, chemical structure of BRD-7389 | p90 RSK inhibitor: insulin stimulator | CAS 376382-11-5
    $80.00
    BRD-7389 (376382-11-5) inhibits p90 ribosomal S6 kinase (RSK), IC50 = 1.2, 1.5 and 2.4 μM for RSK3, RSK1 and RSK2 respectively.1 Induces a β-cell-like state in pancreatic α-cells and induces insulin...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of BT2 | BCKDC kinase inhibitor | CAS 34576-94-8
    $50.00
    BT2 (34576-94-8) is an inhibitor of the mitochondrial branched-chain a-ketoacid dehydrogenase complex kinase (BCKDC) - IC50 = 3.19 µM.1  Inhibition of this kinase has been shown to reduce levels of branched-chain...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of C16 | PKR inhibitor | CAS 608512-97-6
    $60.00
    C16 (608512-97-6) inhibits RNA-dependent protein kinase (PKR, IC50 = 210 nM).1 Inhibits ER stress-induced neuronal damage.2 Reduces brain PKR activation in vivo.3  Prevents apoptosis and IL-1β production in an...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of CID-2011756 | PKD inhibitor | CAS 638156-11-3
    $75.00
    CID-2011756 (638156-11-3) is a potent and selective ATP-competitive inhibitor of protein kinase D (PKD). IC50=3.2, 0.6 and 0.7 μM for PKD1, 2 and 3 respectively. Inhibits phorbol ester-induced PKD activation in LNCaP...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of CZC-54252 | LRRK2 | CAS 1191911-27-9
    $85.00
    CZC-54252 (1191911-27-9) is a novel, potent and selective inhibitor of the leucine-rich repeat kinase-2 (LRRK2), IC50 = 1.28 nM. Also inhibits G2019S mutant LRRK2, IC50 = 1.85 nM1. CZC-54252 attenuates the neuronal damage...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Deguelin | Akt inhibitor | CAS 522-17-8
    $70.00
    Deguelin (522-17-8) inhibits Akt.1,2 Induces apoptosis in a variety of cells.2,3 Displays cancer chemopreventive activity.4 Deguelin is cell permeable and active in vivo. References/Citations1) Chun et al...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure Dorsomorphin | AMPK inhibitor | CAS 866405-64-3
    $60.00
    Dorsomorphin (866405-64-3) is a potent, selective and ATP-competitive inhibitor of AMP-activated protein kinase (AMPK) (Ki = 109 nM).1 It displays no significant inhibition of ZAPK, SYK, PKCT, PKA and JAK3. It inhibits bone...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of FAK inhibitor 14 | FAK inhibitor | CAS 4506-66-5
    $45.00
    FAK inhibitor 14 (4506-66-5) is a selective focal adhesion kinase (FAK) inhibitor that displays no significant activity at a range of other kinases including EGFR, PDGFR and IGF-RI. Prevents FAK autophosphorylation at Y397...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure GSK-690693 HCl | AKT inhibitor | CAS 937174-76-0
    $98.00
    GSK-690693 (937174-76-0) is a novel ATP-competitive pan-specific Akt kinase inhibitor. (IC50's=2, 13, 9 nM for Akt1, 2 and 3 respectively) Antitumor activity. Active in vivo. GSK-690693 induces hyperglycemia. Cell permeable...

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