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P38

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Doramapimod | p38 MAPK inhibitor | CAS 285983-48-4
    $50.00
    Doramapimod (285983-48-4) potently and selectively inhibits p38 MAPK by simultaneously binding to the ATP-binding domain and an allosteric site.1 (IC50=18 nM). Displays anti-inflammatory activity2 but differential effects on...

  • Focus Biomolecules cell signaling reagent supplier, structure JX-401 | p38 alpha MAP kinase inhibitor | CAS 349087-34-9
    $110.00
    JX401 (349087-34-9) is a potent, cell-permeable inhibitor of p38α (IC50 = 32 nM). No inhibition of p38β was observed at 10 μM. References/Citations1) Friedmann et al. (2006), JX401,a p38α inhibitor...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of LFM-A13 | BTK inhibitor | CAS 244240-24-2
    $70.00
    LFM-A13 (244240-24-2) is a selective inhibitor of Bruton's tyrosine kinase (BTK) - IC50's = 2.5 μM (recombinant BTK) and 17.2 μM (human BTK).1,2 It has also been shown to inhibit Polo-like kinase (PLK) - IC50 = 61...

  • Focus Biomolecules supplier, chemical structure of SB 202190 | p38 MAP kinase inhibitor | CAS 152121-30-7
    $30.00
    SB 202190 (152121-30-7) is a potent and selective p38 MAP kinase inhibitor acting at the ATP site.1 Selectively inhibits the p38α and β isoforms (IC50= 50 and 100 nM for SAPK2a/p38 and SAPK2b/p38β2...

  • Focus Biomolecules supplier, chemical structure of SB 203580 | p38 MAP kinase inhibitor | CAS 152121-47-6
    $75.00
    SB 203580 (152121-47-6) is a potent and selective inhibitor of p38 MAP kinase, IC50=50 and 500 nM for p38 and p38β2 respectively. No other kinases (in a panel of 30) were significantly inhibited including p38γ and...

  • VX-702 | P38alpha MAP kinase inhibitor
    $40.00
    VX-702 (745833-23-2) is a  potent and selective inhibitor of p38 MAP kinases, p38α MAPK and p38β (KD = 3.7 and 17 nM respectively).1 Inhibits IL-6, IL-1β and TNFα production in LPS-primed blood.1...

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