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  • Axitinib | VEGFR kinase inhibitor
    Axitinib (319460-85-0) is a potent inhibitor of VEGFR-2, -3, and -1, IC50 = 0.2, 0.1-0.3, and 1.2 nM respectively1 displaying minimal activity against a panel of ~100 protein kinases. Inhibits angiogenesis and vascular...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of DMPQ 2HCl | PDGFR inhibitor | CAS 137206-97-4
    DMPQ 2HCl (137206-97-4) is a potent and selective inhibitor of PDGFRβ, IC50=80 nM. Greater than 100-fold more selective compared to EGFR, erB2, p56, PKA and PKC. Cell permeable. References/Citations1) Dolle et al...

  • Focus Biomolecules cell signaling reagent supplier, structure of SU-4312 | VEGFR / PDGFR kinase inhibitor | CAS 5813-07-7
    SU-4312 (5812-07-7) is a potent selective inhibitor of VEGFR kinase (also known as Flk-1 and KDR). Inhibition of the activated kinase (IC50 = 0.4 μM) is 100-fold less than inhibition of the unactivated kinase (IC50 = 0.04...

  • Focus Biomolecules, Tyrphostin 9 structure | PDGFR kinase inhibitor & Oxidative phosphorylation inhibitor | CAS 10537-47-0
    Tyrphostin 9 (10537-47-0) inhibits PDGF receptor tyrosine kinase (IC50 = 1.2 μM)1 and is a potent (10 nM) inhibitor of oxidative phosphorylation2. Inhibits cell growth by disrupting mitochondria3. Tyrphostin 9 perturbs...

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