KT-5823 (126643-37-6) is a selective protein kinase G inhibitor (K>i =0.23, 4 and >10 μM for PKG, PKC and PKA respectively1. Arrests human skin fibroblast cell cycle after the G0/G1 boundary2. KT-5823 abolishes the cGMP-induced relaxation in smooth muscle cells (IC50=60 nM)3. Cell permeable.
1) Kase et al. (1987), K252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases; Biochem. Biophys. Res. Commun., 142 436
2) Gadbois et al. (1992), Multiple kinase arrest points in the G1 phase of nontransformed mammalian cells are absent in transformed cells; Proc. Natl. Acad. Sci. USA, 89 8626
3) Murthy et al. (1995), Interaction of cA-kinase and cG-kinase in mediating relaxation of dispersed smooth muscle cells; Am. J. Physiol., 268 C171