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Product Details

KT-5823 | PKA inhibitor

KT-5823 (126643-37-6) is a selective protein kinase G inhibitor (K>i =0.23, 4 and >10 μM for PKG, PKC and PKA respectively1. Arrests human skin fibroblast cell cycle after the G0/G1 boundary2. KT-5823 abolishes the cGMP-induced relaxation in smooth muscle cells (IC50=60 nM)3. Cell permeable.

References/Citations
1) Kase et al. (1987), K252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases; Biochem. Biophys. Res. Commun., 142 436
2) Gadbois et al. (1992), Multiple kinase arrest points in the G1 phase of nontransformed mammalian cells are absent in transformed cells; Proc. Natl. Acad. Sci. USA, 89 8626
3) Murthy et al. (1995), Interaction of cA-kinase and cG-kinase in mediating relaxation of dispersed smooth muscle cells; Am. J. Physiol., 268 C171

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Focus Biomolecules cell signaling reagent supplier, chemical structure of KT-5823 | PKA inhibitor | CAS 126643-37-6

Catalog#  10-2083

$90.00
Quantity
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CAS:
126643-37-6
Catalog Number:
10-2083
Activity:
PKA inhibitor
Molecular Weight:
495.53
Molecular Formula:
C29H25N3O5
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in DMF (up to 20 mg/ml).
Physical Properties:
White or off white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or DMF may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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