my account
  Loading... Please wait...

Product Details

Manumycin A | Farnesyltransferase inhibitor

Manumycin A (52665-74-4) inhibits ras farnesyltransferase1 and prevents ras signaling2. Irreversibly inhibits neutral sphingomyelinase3. Abrogates IL-1β-induced HIF-1α activation in both glioma and non-glioma tumor cells4. Ameliorates acetaminophen-induced liver injury in mice5. Induces apoptosis and displays antiproliferative activity in various models3. Cell permeable.


1) Hara et al. (1993), Identification of Ras Farnesyltransferase inhibitors by microbial screening; Proc. Natl. Acad. Sci. USA, 90 2281
2) DiPaolo et al. (2000), Maunumycin inhibits ras signal transduction pathway and induces apoptosis in COLO320-DM human colon tumour cells; Br. J. Cancer, 82 905
3) Arenz et al. (2001), Manumycin A and its analogies are irreversible inhibitors of neutral sphingomyelinase; Chem. Bio. Chem., 2 141
4) Sharma et al. (2012), Farnesyltransferase inhibitor manumycin targets IL1β-Ras-HIF-1α axis in tumor cells of diverse origin; Inflammation, 35 516
5) Saha and Nandi (2009), Farnesyltransferase inhibitors reduce Ras activation and ameliorate acetaminophen-induced liver injury in mice; Hepatology, 50 1547
6) Singha et al. (2013), Manumycin A inhibits triple-negative breast cancer growth through LC3-mediated cytoplasmic vacuolation death; Cell Death Dis., 4 e457

Image 1

Catalog#  10-2683-0001

Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
Request Bulk Quote
Catalog Number:
Farnesyltransferase inhibitor
Fermentation product from Streptomyces parvulus
Molecular Weight:
Molecular Formula:
Soluble in DMSO (up to 10 mg/ml), in Ethanol (up to 5 mg/ml) or in DMF (up to 20 mg/ml)
Physical Properties:
Yellow solid
97% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stable for 1 year as supplied. Solutions in DMSO, ethanol, or DMF may be stored at -20°C for up to 3 months.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

Connect with Focus

Click the button below to add the Manumycin A | Farnesyltransferase inhibitor to your wish list.