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Manzamine A | Inhibitor of vacuolar ATPases

Manzamine A (104196-68-1) inhibits vacuolar ATPases and inhibits autophagy in pancreatic cancer cells1. Suppresses atherosclerosis in vivo2. Manzamine A displays neuritogenic activity3 and suppresses tau hyperphosphorylation in human neuroblastoma cell lines4.

1) Kallifatidis et al. (2013), The marine natural product manzamine A targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells; Mar. Drugs, 11 3500
2) Eguchi et al. (2013), Manzamine A, a marine-derived alkaloid, inhibits accumulation of cholesterol ester in macrophages and suppresses hyperlipidemia and atherosclerosis in vivo; Bioorg. Med. Chem., 21 3831
3) Zhang et al. (2008), Neuritogenic activity-guided isolation of a free base form manzamine A from a marine sponge, Acanthostrongylophora aff. Igens (Thiele, 1899); Chem. Pharm. Bull., 56 866
4) Hamann et al. (2007), Glycogen synthase kinase-3 (GSK-3) inhibitory activity and structure-activity relationship (SAR) studies of the manzamine alkaloids. Potential for Alzheimer's disease; J. Nat. Prod., 70 1397

Focus Biomolecules supplier, chemical structure of Manzamine A | Inhibitor of vacuolar ATPases | CAS 104196-68-1

Catalog#  10-2675

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Catalog Number:
Inhibitor of vacuolar ATPases
Alternate Names:
Marine natural product isolated from Xestospongia ashmorica
Molecular Weight:
Molecular Formula:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
Lyophilized solid
98% by HPLC
NMR (Conforms)
Storage Temperature:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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