my account
Login
  Loading... Please wait...

Membrane Transporters

Sort by
  • Focus Biomolecules reagent supplier, chemical structure of Bafilomycin A1 | Vacuolar H+ ATPase inhibitor | CAS 88899-55-2
    Bafilomycin A1 | Vacuolar H+ ATPase inhibitor
    $80.00
    Bafilomycin A1 (88899-55-2) is a macrolide antibiotic derived from Streptomyces griseus that is a potent and selective inhibitor of vacuolar H+-ATPases (IC50 = 0.6 – 1.5 nM).1,2 Bafilomycin A1 inhibits autophagy via...

    Choose Options
  • Focus Biomolecules cell signaling supplier, chemical structure of Dipyridamole | Pan-specific PDE inhibitor | CAS 58-32-2
    Dipyridamole | Pan-specific PDE inhibitor
    $22.00
    Dipyridamole (58-32-2) is a phosphodiesterase inhibitor (IC50=0.37, 0.38, 0.45, 0.9 and 4.5 μM for PDE11, 6, 10, 5 and 8 respectively.1,2 Potent equilibrative nucleoside transporter 1 (ENT1) inhibitor Ki=8.2 nM vs. 144.8...

    Choose Options
  • Ezetimibe | Cholesterol absorption inhibitor
    Ezetimibe | Cholesterol absorption inhibitor
    $45.00
    Ezetimibe (163222-33-1) inhibits cholesterol absorption in the intestine by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L1) protein, a cholesterol transporter.1 Undergoes rapid glucuronidation in the...

    Choose Options
  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Geldanamycin-FITC | HSP90 fluorescent probe
    Geldanamycin-FITC | HSP90 fluorescent probe
    $200.00
    Geldanamycin-FITC is a novel geldanamycin fluorescent probe1 that may be used in a fluorescence polarization assay for HSP-90 inhibitors.2,3 May also be used for detection of cell surface HSP-90 and for other applications...

    Choose Options
  • Focus Biomolecules cell signaling reagent supplier, structure KB-R7943 mesylate | TRPC channel blocker | CAS 182004-65-5
    KB-R7943 mesylate | TRPC channel blocker
    $65.00
    KB-R7943 (182004-65-5) is a potent and selective inhibitor of the reversed Na+/Ca2+ exchanger (NCE or NCX; IC50's = 1.2-2.4 μM in cardiomyocytes, smooth muscle cells, NCX1-transfected fibroblasts1; 0.7 μM in cultured...

    Choose Options
  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Ko-143 | BCRP inhibitor | CAS 461054-93-3
    Ko-143 | BCRP inhibitor
    $100.00
    A potent and selective inhibitor of the breast cancer resistance protein multidrug transporter (BCRP/ABCG2)1. Reverses resistance of MTX and topotecan at 25 nM in human and mouse cell lines.1 Also inhibits ABCB1 and ABCC1 at...

    Choose Options
  • Focus Biomolecules supplier, chemical structure of Manzamine A | Inhibitor of vacuolar ATPases | CAS 104196-68-1
    Manzamine A | Inhibitor of vacuolar ATPases
    $185.00
    Manzamine A (104196-68-1) inhibits vacuolar ATPases and inhibits autophagy in pancreatic cancer cells1. Suppresses atherosclerosis in vivo2. Manzamine A displays neuritogenic activity3 and suppresses tau...

    Choose Options
  • Focus Biomolecules cell signaling reagent supplier, chemical structure of MRL-24 | PPARγ partial agonist | CAS 393794-17-7
    MRL-24 | PPAR gamma partial agonist
    $65.00
    MRL-24 displays high affinity for PPARγ with excellent anti-diabetic activity in mice but poor PPARγ agonist activity in transcription and adipogenesis assays. MRL-24 is highly effective (30 nM) at blocking...

    Choose Options
  • Focus Biomolecules supplier, chemical structure of Nigericin Na | Induces rapid intracellular acidification | CAS 28643-80-3
    Nigericin Na | Induces rapid intracellular acidification
    $50.00
    Nigericin Na (28643-80-3) is a polyether ionophore which disrupts membrane potential and stimulates ATPase activity in mitochondria. Induces apoptosis resulting from intracellular acidification. Ion selectivity for nigericin...

    Choose Options
  • Focus Biomolecules supplier, chemical structure of Oligomycin Complex | Mitochondrial ATPase inhibitor | CAS 1404-19-9
    Oligomycin Complex | Mitochondrial ATPase inhibitor
    $57.00
    Oligomycin (1404-19-9) inhibits mitochondrial F1F0 ATP synthase.1 A useful tool for decreasing cellular ATP levels.2 Induces autophagy.3 Stimulates lysosome acidification.4 Oligomycin protects against ischemic kidney in male...

    Choose Options
  • Focus Biomolecules cell signaling reagent supplier, structure of Ouabain | Na+/K+ ATPase inhibitor | CAS 11018-89-6
    Ouabain | Na+/K+ ATPase inhibitor
    $25.00
    Ouabain (11018-89-6) is a selective inhibitor of Na+ K+-ATPase isolated from Strophanthus gratus1. Endogenous ouabain is found in human circulation2. Displays cardiotonic and diuretic activity. May be used to induce...

    Choose Options
  • Focus Biomolecules cell signaling supplier, chemical structure of Pepstatin A | Aspartic protease inhibitor | CAS 26305-03-3
    Pepstatin A | Aspartic protease inhibitor
    $30.00
    Pepstatin A (26305-03-3) is a selective inhibitor of aspartyl proteases.1 Inhibits human pepsin, human gastricsin, renin, cathepsin D and E and bovine chymosin.2 Does not inhibit thiol proteases, neutral proteases or serine...

    Choose Options
  • Focus Biomolecules supplier, chemical structure of Pimaricin (Natamycin) | Antifungal Polyene macrolide | CAS 7681-93-8
    Pimaricin (Natamycin) | Antifungal Polyene macrolide
    $48.00
    Pimaricin (7681-93-8) is a polyene macrolide topical antifungal agent. Specifically binds to ergosterol and inhibits fungal growth, not by forming pores in the plasma membrane (as is the case with other polyene macrolides...

    Choose Options
  • Focus Biomolecules reagent supplier, chemical structure of Sulfasalazine | Anti-inflammatory / antibiotic | CAS 599-79-1
    Sulfasalazine | Anti-inflammatory / antibiotic
    $20.00
    Sulfasalazine (599-79-1) is an approved drug with diverse potential applications. Sulfasalzine is a clinically useful agent for the treatment of colitis and ileocolitis.1 It is metabolized by intestinal bacteria to release...

    Choose Options
  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Tetrabenazine | VMAT2 inhibitor | CAS 58-46-8
    Tetrabenazine | VMAT2 inhibitor
    $30.00
    Tetrabenazine (58-46-8) is a potent inhibitor of the vesicular monoamine transporter (VMAT), IC50=3.2 nM1,2 with selectivity for VMAT2 over VMAT13. Promotes late stage differentiation of Pdx1-positive pancreatic progenitor...

    Choose Options
  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Thapsigargin | SERCA inhibitor | CAS 67526-95-8
    Thapsigargin | SERCA inhibitor
    $58.00
    Thapsigargin (67526-95-8) is a potent inhibitor of sarco-endoplasmic reticulum Ca2+ -ATPase1. (IC50= 30 nM) Induces endoplasmic reticulum stress and autophagy in a variety of cell lines2. Warning: Thapsigargin is highly...

    Choose Options
  • Focus Biomolecules cell signaling supplier, chemical structure of WZB117 | Glucose transport inhibitor | CAS 1223397-11-2
    WZB117 | Glucose transport inhibitor
    $45.00
    WZB117 (1223397-11-2) is an inhibitor of Glucose Transporter 1 (GLUT1). It inhibited cell proliferation in lung cancer A549 cells and breast cancer MCF7 cells with an IC50 of approximately 10 μM. Daily intraperitoneal...

    Choose Options

Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21

Connect with Focus