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Membrane Transporters

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  • Bafilomycin A1 | Vacuolar H+ ATPase inhibitor
    Bafilomycin A1 | Vacuolar H+ ATPase inhibitor
    $80.00
    Bafilomycin A1 (88899-55-2) is a macrolide antibiotic derived from Streptomyces griseus that is a potent and selective inhibitor of vacuolar H+-ATPases (IC50 = 0.6 – 1.5 nM).1,2 Bafilomycin A1 inhibits autophagy via...

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  • Dipyridamole | 58-32-2 | Structure | Supplier
    Dipyridamole | Pan-specific PDE inhibitor
    $22.00
    Dipyridamole (58-32-2) is a phosphodiesterase inhibitor (IC50=0.37, 0.38, 0.45, 0.9 and 4.5 μM for PDE11, 6, 10, 5 and 8 respectively.1,2 Potent equilibrative nucleoside transporter 1 (ENT1) inhibitor Ki=8.2 nM vs. 144.8...

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  • Geldanamycin-FITC | Structure | Supplier
    Geldanamycin-FITC | HSP90 fluorescent probe
    $200.00
    Geldanamycin-FITC is a novel geldanamycin fluorescent probe1 that may be used in a fluorescence polarization assay for HSP-90 inhibitors.2,3 May also be used for detection of cell surface HSP-90 and for other applications...

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  • KB-R7943 mesylate | 182004-65-5 | Structure | Supplier
    KB-R7943 mesylate | TRPC channel blocker
    $65.00
    KB-R7943 (182004-65-5) is a potent and selective inhibitor of the reversed Na+/Ca2+ exchanger (NCE or NCX; IC50's = 1.2-2.4 μM in cardiomyocytes, smooth muscle cells, NCX1-transfected fibroblasts1; 0.7 μM in cultured...

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  • Ko-143 | 461054-93-3 | Structure | Supplier
    Ko-143 | BCRP inhibitor
    $100.00
    A potent and selective inhibitor of the breast cancer resistance protein multidrug transporter (BCRP/ABCG2)1. Reverses resistance of MTX and topotecan at 25 nM in human and mouse cell lines.1 Also inhibits ABCB1 and ABCC1 at...

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  • Manzamine A | Inhibitor of vacuolar ATPases
    Manzamine A | Inhibitor of vacuolar ATPases
    $185.00
    Manzamine A (104196-68-1) inhibits vacuolar ATPases and inhibits autophagy in pancreatic cancer cells1. Suppresses atherosclerosis in vivo2. Manzamine A displays neuritogenic activity3 and suppresses tau...

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  • MRL-24 | Structure | Supplier
    MRL-24 | PPAR gamma partial agonist
    $65.00
    MRL-24 displays high affinity for PPARγ with excellent anti-diabetic activity in mice but poor PPARγ agonist activity in transcription and adipogenesis assays. MRL-24 is highly effective (30 nM) at blocking...

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  • Nigericin Na | Induces rapid intracellular acidification
    Nigericin Na | Induces rapid intracellular acidification
    $50.00
    Nigericin Na (28643-80-3) is a polyether ionophore which disrupts membrane potential and stimulates ATPase activity in mitochondria. Induces apoptosis resulting from intracellular acidification. Ion selectivity for nigericin...

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  • Oligomycin Complex | Mitochondrial ATPase inhibitor
    Oligomycin Complex | Mitochondrial ATPase inhibitor
    $55.00
    Oligomycin (1404-19-9) inhibits mitochondrial F1F0 ATP synthase.1 A useful tool for decreasing cellular ATP levels.2 Induces autophagy.3 Stimulates lysosome acidification.4 Oligomycin protects against ischemic kidney in male...

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  • Ouabain | 11018-89-6 | Structure | Supplier
    Ouabain | Na+/K+ ATPase inhibitor
    $25.00
    Ouabain (11018-89-6) is a selective inhibitor of Na+ K+-ATPase isolated from Strophanthus gratus1. Endogenous ouabain is found in human circulation2. Displays cardiotonic and diuretic activity. May be used to induce...

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  • Pepstatin A | 26305-03-3 | Structure | supplier
    Pepstatin A | Aspartic protease inhibitor
    $30.00
    Pepstatin A (26305-03-3) is a selective inhibitor of aspartyl proteases.1 Inhibits human pepsin, human gastricsin, renin, cathepsin D and E and bovine chymosin.2 Does not inhibit thiol proteases, neutral proteases or serine...

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  • Pimaricin (Natamycin) | Antifungal Polyene macrolide
    Pimaricin (Natamycin) | Antifungal Polyene macrolide
    $48.00
    Pimaricin (7681-93-8) is a polyene macrolide topical antifungal agent. Specifically binds to ergosterol and inhibits fungal growth, not by forming pores in the plasma membrane (as is the case with other polyene macrolides...

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  • Sulfasalazine | Anti-inflammatory / antibiotic
    Sulfasalazine | Anti-inflammatory / antibiotic
    $20.00
    Sulfasalazine (599-79-1) is an approved drug with diverse potential applications. Sulfasalzine is a clinically useful agent for the treatment of colitis and ileocolitis.1 It is metabolized by intestinal bacteria to release...

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  • Tetrabenazine | VMAT2 inhibitor
    Tetrabenazine | VMAT2 inhibitor
    $50.00
    Tetrabenazine (58-46-8) is a potent inhibitor of the vesicular monoamine transporter (VMAT), IC50=3.2 nM1,2 with selectivity for VMAT2 over VMAT13. Promotes late stage differentiation of Pdx1-positive pancreatic progenitor...

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  • Thapsigargin | SERCA inhibitor
    Thapsigargin | SERCA inhibitor
    $58.00
    Thapsigargin (67526-95-8) is a potent inhibitor of sarco-endoplasmic reticulum Ca2+ -ATPase1. (IC50= 30 nM) Induces endoplasmic reticulum stress and autophagy in a variety of cell lines2. Warning: Thapsigargin is highly...

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  • WZB117 | Glucose transport inhibitor
    WZB117 | Glucose transport inhibitor
    $45.00
    WZB117 (1223397-11-2) is an inhibitor of Glucose Transporter 1 (GLUT1). It inhibited cell proliferation in lung cancer A549 cells and breast cancer MCF7 cells with an IC50 of approximately 10 μM. Daily intraperitoneal...

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