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  • Focus Biomolecules cell signaling supplier, chemical structure of Dipyridamole | Pan-specific PDE inhibitor | CAS 58-32-2
    $22.00
    Dipyridamole (58-32-2) is a phosphodiesterase inhibitor (IC50=0.37, 0.38, 0.45, 0.9 and 4.5 μM for PDE11, 6, 10, 5 and 8 respectively.1,2 Potent equilibrative nucleoside transporter 1 (ENT1) inhibitor Ki=8.2 nM vs. 144.8...

  • Ezetimibe | Cholesterol absorption inhibitor
    $45.00
    Ezetimibe (163222-33-1) inhibits cholesterol absorption in the intestine by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L1) protein, a cholesterol transporter.1 Undergoes rapid glucuronidation in the...

  • Focus Biomolecules cell signaling reagent supplier, structure KB-R7943 mesylate | TRPC channel blocker | CAS 182004-65-5
    $65.00
    KB-R7943 (182004-65-5) is a potent and selective inhibitor of the reversed Na+/Ca2+ exchanger (NCE or NCX; IC50's = 1.2-2.4 μM in cardiomyocytes, smooth muscle cells, NCX1-transfected fibroblasts1; 0.7 μM in cultured...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Ko-143 | BCRP inhibitor | CAS 461054-93-3
    $100.00
    A potent and selective inhibitor of the breast cancer resistance protein multidrug transporter (BCRP/ABCG2)1. Reverses resistance of MTX and topotecan at 25 nM in human and mouse cell lines.1 Also inhibits ABCB1 and ABCC1 at...

  • Focus Biomolecules supplier, chemical structure of Nigericin Na | Induces rapid intracellular acidification | CAS 28643-80-3
    $50.00
    Nigericin Na (28643-80-3) is a polyether ionophore which disrupts membrane potential and stimulates ATPase activity in mitochondria. Induces apoptosis resulting from intracellular acidification. Ion selectivity for nigericin...

  • Focus Biomolecules supplier, chemical structure of Pimaricin (Natamycin) | Antifungal Polyene macrolide | CAS 7681-93-8
    $48.00
    Pimaricin (7681-93-8) is a polyene macrolide topical antifungal agent. Specifically binds to ergosterol and inhibits fungal growth, not by forming pores in the plasma membrane (as is the case with other polyene macrolides...

  • Focus Biomolecules reagent supplier, chemical structure of Sulfasalazine | Anti-inflammatory / antibiotic | CAS 599-79-1
    $20.00
    Sulfasalazine (599-79-1) is an approved drug with diverse potential applications. Sulfasalzine is a clinically useful agent for the treatment of colitis and ileocolitis.1 It is metabolized by intestinal bacteria to release...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Thapsigargin | SERCA inhibitor | CAS 67526-95-8
    $58.00
    Thapsigargin (67526-95-8) is a potent inhibitor of sarco-endoplasmic reticulum Ca2+ -ATPase1. (IC50= 30 nM) Induces endoplasmic reticulum stress and autophagy in a variety of cell lines2. Warning: Thapsigargin is highly...

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