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BiochemicalTargets

Membrane transporters

Membrane transporters are proteins that span the cell membrane and function in moving substances into or out of the cell. Transported substances range from salt ions, to glucose, to monoamines, to proteins. Some transporters, such as pores and ion channels, move their targets passively, while others utilize ATP (e.g. Na⁺/K⁺-ATPase) or an electrochemical gradient [e.g. excitatory amino acid transporters (EAATs)] for energy to accomplish transport.

ABC

T0901317 | LXR Agonist

T0901317 (293754-55-9) is a  potent high affinity liver X receptor (LXRα and β) agonist, EC50~50 nM.1   Upregulates expression of ABCA1, a reverse cholesterol transporter, resulting in

S-Farnesyl-L-cysteine methyl ester | Multidrug resistance transporter activator

CAS:
125741-64-2
Catalog Number:
10-4608
Activity:
Multidrug resistance transporter activator
Chemical Name:
(2R)-2-Amino-3-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl]sulfanylpropanoic acid methyl ester
Molecular Weight:
339.54
Molecular Formula:
C19H33NO2S
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml)
Physical Properties:
Pale yellow oil
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Amino acid

V-9302 | Glutamine transport inhibitor

CAS:
1855871-76-9
Catalog Number:
10-4245
Activity:
Glutamine transport inhibitor
Chemical Names:
(2S)-2-Amino-4-[bis[[2-[(3-methylphenyl)methoxy]phenyl]methyl]amino]butanoic acid
Molecular Weight:
538.69
Molecular Formula:
C34H38N2O4
Solubility:
Soluble in DMSO (at least 70 mg/ml); ethanol (at least 30 mg/ml)
Physical Properties:
Off-white solid
Purity:
98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

JPH203 | LAT1 inhibitor

CAS:
1597402-27-1
Catalog Number:
10-4464
Activity:
LAT1 inhibitor
Chemical Names:
(2S)-2-Amino-3-[4-[(5-amino-2-phenyl-1,3-benzoxazol-7-yl)methoxy]-3,5-dichlorophenyl]propanoic acid dihydrochloride
Alternate Name:
KYT-0353; Nanvuralant
Molecular Weight:
545.24
Molecular Formula:
C23H19Cl2N3O4·2HCl
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
Pale orange/yellow solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

UCPH-101 | EAAT1 inhibitor

CAS:
1118460-77-7
Catalog Number:
10-4880
Activity:
EAAT1 inhibitor
Chemical Name:
2-Amino-4-(4-methoxyphenyl)-7-naphthalen-1-yl-5-oxo-4,6,7,8-tetrahydrochromene-3-carbonitrile
Molecular Weight:
422.48
Molecular Formula:
C27H22N2O3
Solubility:
Soluble in DMSO (up to 10 mg/ml).
Physical Properties:
Off-white solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
RT

ATPases

Dihydroouabain | Endogenous ouabain-like factor

CAS:
1183-35-3
Catalog Number:
10-3125
Activity:
Endogenous ouabain-like factor
Chemical Names:
3-[(6-Deoxyhexopyranosyl)oxy]-1,5,11,14,19-pentahydroxycardanolide
Molecular Weight:
586.68
Molecular Formula:
C29H46O12
Solubility:
Soluble in DMSO (30 mg/ml); Ethanol (30 mg/ml)
Physical Properties:
White solid
Purity:
>95% HPLC/TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Oligomycin A | Mitochondrial ATPase inhibitor

CAS:
579-13-5
Catalog Number:
10-5368
Activity:
Mitochondrial ATPase inhibitor
Source:
Streptomyces sp.
Molecular Weight:
791.06
Molecular Formula:
C45H74O11
Solubility:
Soluble in DMSO (up to 300 mg/ml); Ethanol (up to 200 mg/ml)
Physical Properties:
White solid
Purity:
>98% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Glucose

BAY-876 | GLUT1 inhibitor

CAS:
1799753-84-6
Catalog Number:
10-4708
Activity:
GLUT1 inhibitor
Chemical Names:
N4-[1-(4-Cyanobenzyl)-5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-7-fluoroquinoline-2,4-dicarboxamide
Molecular Weight:
496.43
Molecular Formula:
C24H16F4N6O2
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
White solid
Purity:
98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Canagliflozin | SGLT2 inhibitor

CAS:
842133-18-0
Catalog Number:
10-3576
Activity:
SGLT2 inhibitor
Chemical Names:
(1S)-1,5-anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-D-glucitol;
JNJ-24831754
Molecular Weight:
444.52
Molecular Formula:
C24H25FO5S
Solubility:
Soluble in DMSO (40 mg/ml)
Physical Properties:
White solid
Purity:
98% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

5-Thio-D-glucose | Glucose transport inhibitor

CAS:
20408-97-3
Catalog Number:
10-1398
Activity:
Glucose transport inhibitor
Chemical Names:

5-Thio-5-deoxy-D-glucose; 5TG

Molecular Weight:
196.22
Molecular Formula:
C6H12O5S
Solubility:
Soluble in Water (up to 15 mg/ml)
Physical Properties:
White solid
Purity:
97% HPLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years as supplied. Solutions in distilled water may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Monoamine

Bupropion HCl | Monoamine transporter inhibitor

CAS:
31677-93-7
Catalog Number:
10-2462
Activity:
Monoamine transporter inhibitor
Chemical Names:
1-(3-Chlorophenyl)-2-[(1,1-dimethylethyl)amino]-1-propanone hydrochloride
Molecular Weight:
276.20
Molecular Formula:
C13H18ClNO·HCl
Solubility:
Soluble in DMSO (40 mg/ml)
Physical Properties:
White solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Reserpine | VMAT1,2 inhibitor

CAS:
50-55-5
Catalog Number:
10-2689
Activity:
VMAT1 and 2 inhibitor
Chemical Names:
(3β,16β,17α,18β,20α)-11,17-dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]-yohimban-16-carboxylic acid, methyl ester; NSC59272
Molecular Weight:
608.68
Molecular Formula:
C33H40N2O9
Solubility:
Soluble in DMSO (35 mg/ml)
Physical Properties:
Off-white solid
Purity:
98% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Tiagabine hydrochloride | GABA transporter 1 (GAT1) inhibitor

CAS:
145821-59-6
Catalog Number:
10-4384
Activity:
GABA transporter 1 (GAT1) inhibitor
Chemical Name:
(3R)-1-[4,4-Bis(3-methylthiophen-2-yl)but-3-enyl]piperidine-3-carboxylic acid
Alternate Name:
NO-328
Molecular Weight:
412.00
Molecular Formula:
C20H25NO2S2 • HCl
Solubility:
Soluble in DMSO (up to at least 25 mg/ml), in Ethanol (up to at least 25 mg/ml) or in Water (up to at least 30 mg/ml)
Physical Properties:
Off-white or beige solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO, ethanol, or distilled water may be stored at -20° for up to 3 months.
Shipping Code:
RT

Other

BI01383298 | Citrate transporter inhibitor

BI01383298 (2227549-00-8) is a potent, non-competitive, irreversible inhibitor of the human Na+-coupled citrate transporter (NaCT/SLC13A5/mINDY).1,2  IC50 = 49 nM in the presence of Li+ with preincubation

SLF1081851 | Sphingosine-1-phosphate transporter inhibitor

CAS:
2763730-97-6 (free base)
Catalog Number:
10-4395
Activity:
Sphingosine-1-phosphate transporter inhibitor
Chemical Names:
3-(3-(4-Decylphenyl)-1,2,4-oxadiazol-5-yl)propan-1-amine hydrochloride
Molecular Weight:
379.97
Molecular Formula:
C21H33N3O·HCl
Solubility:
Soluble in DMSO (30 mg/ml); Ethanol (7 mg/ml)
Physical Properties:
White solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Metolazone | UPR activator and longevity inducer

CAS:
17560-51-9
Catalog Number:
10-5417
Activity:
UPR activator and longevity inducer
Chemical Name:

7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide

Molecular Weight:
365.83
Molecular Formula:
C16H16ClN3O3S
Solubility:
Soluble in DMSO (up to 36 mg/ml)
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored desiccated at -20°C for up to 2 months.
Shipping Code:
RT