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Tetrabenazine | VMAT2 inhibitor

CAS:
58-46-8
Catalog Number:
10-2672
Activity:
VMAT2 inhibitor
Chemical Name:
(3R,11bR)-rel-1,3,4,6,7,11b-Hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-one
Molecular Weight:
317.43
Molecular Formula:
C19H27NO3
Solubility:
Soluble in DMSO (up to 30 mg/ml), or in Ethanol (up to 9 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 week.
Shipping Code:
RT

Tetrabenazine (58-46-8) is a potent inhibitor of the vesicular monoamine transporter (VMAT), IC50=3.2 nM1,2 with selectivity for VMAT2 over VMAT13. Promotes late stage differentiation of Pdx1-positive pancreatic progenitor cells into Neurog3-positive endocrine precursors.4

References/Citations:

1) Scherman et al. (1983), Characterization of the monoamine carrier of chromaffin granule membrane by binding of [2-3H]dihydrotetrabenazine; Proc. Natl. Acad. Sci. USA, 80 584
2) Peter et al. (1996), Chimeric vesicular monoamine transporters identify structural domains that influence substrate affinity and sensitivity to tetrabenazine; J. Biol. Chem., 271 2979
3) Schafer et al. (2013), Localization and expression of VMAT2 across mammalian species: a translational guide for it’s visualization and targeting in health and disease; Adv. Pharmacol., 68 319
4) Sakano et al. (2014), VMAT2 identified as a regulator of late-stage β-cell differentiation; Nat. Chem. Biol., 10 141

Tetrabenazine | VMAT2 inhibitor is also available in the Cellular Metabolism Library.
CAS:
58-46-8
Catalog Number:
10-2672
Activity:
VMAT2 inhibitor
Chemical Name:
(3R,11bR)-rel-1,3,4,6,7,11b-Hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-one
Molecular Weight:
317.43
Molecular Formula:
C19H27NO3
Solubility:
Soluble in DMSO (up to 30 mg/ml), or in Ethanol (up to 9 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 week.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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