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Mitochondria are organelles found in every cell and provide most of the energy for cellular functioning and survival. They also help regulate cellular metabolism, are involved in apoptosis, calcium signaling, cell cycle control, and cell growth and differentiation. Mitochondrial dysfunction has been implicated in metabolic disorders, neurodegenerative diseases, ischemia-related heart and brain injury, cancer, cardiovascular disease, and other disorders.

View All Mitochondria Reagents

Respiratory Chain / Oxidative Phosphorylation

  • HQNO

    Potent respiratory chain inhibitor - binds to mitochondrial cytochrome b.

  • N-Oleoylphenylalanine

    N-Oleoylphenylalanine is an endogenous uncoupler of mitochondrial respiration

  • FCCP

    FFCP is a potent uncoupler of mitochondrial respiration Membrane permeability

View All Respiratory Chain / Oxidative Phosphorylation Reagents

Membrane Permeability

  • Betulinic acid

    Betulinic acid induces mitochondrial permeability transition pore opening

  • Decylubiquinone

    Decylubiquinone inhibits the Ca2+ dependent mitochondrial permeability transition pore without inhibiting respiration

  • Mdivi

    Mdivi is a selective inhibitor of Dnm1 GTPase that inhibits mitochondrial outer membrane permeabilization

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Membrane potential

  • Valinomycin

    Selective K+ ionophore that causes a rapid loss of mitochondrial membrane potential

  • Tropodithietic acid

    Tropodithietic acid displays cytotoxic effects acting via disruption of mitochondrial membrane potential

  • Nonactin

    Nonactin abolishes mitochondrial membrane potential

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Transporters and Carriers

  • MitoBloCK-6

    Inhibits redox-regulated protein translation into mitochondria

  • Puromycin

    Aminonucleoside antibiotic that inhibits protein transport in mitochondria

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ROS / Glutathione

  • Mitoquinone

    Mitoquinone is a mitochondria-targeted antioxidant

  • Piperlongumine

    Piperlongumine is a glutathione sponge that increases ROS levels

View All ROS/Glutathione Reagents