Mitochondria are organelles found in every cell and provide most of the energy for cellular functioning and survival. They also help regulate cellular metabolism, are involved in apoptosis, calcium signaling, cell cycle control, and cell growth and differentiation. Mitochondrial dysfunction has been implicated in metabolic disorders, neurodegenerative diseases, ischemia-related heart and brain injury, cancer, cardiovascular disease, and other disorders.
Potent respiratory chain inhibitor - binds to mitochondrial cytochrome b.
N-Oleoylphenylalanine is an endogenous uncoupler of mitochondrial respiration
FFCP is a potent uncoupler of mitochondrial respiration Membrane permeability
Betulinic acid induces mitochondrial permeability transition pore opening
Decylubiquinone inhibits the Ca2+ dependent mitochondrial permeability transition pore without inhibiting respiration
Mdivi is a selective inhibitor of Dnm1 GTPase that inhibits mitochondrial outer membrane permeabilization
Selective K+ ionophore that causes a rapid loss of mitochondrial membrane potential
Tropodithietic acid displays cytotoxic effects acting via disruption of mitochondrial membrane potential
Nonactin abolishes mitochondrial membrane potential
Inhibits redox-regulated protein translation into mitochondria
Aminonucleoside antibiotic that inhibits protein transport in mitochondria