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  • (R)-(+)-Etomoxir Na | Carnitine palmitoyltransferase inhibitor
    Etomoxir (828934-41-4) is an irreversible inhibitor of mitochondrial carnitine palmitoyl transferase 1 (CPT1).1 It is widely used to study fatty acid oxidation. Etomoxir has been investigated as a therapeutic agent for heart...

  • Chemical structure 2-AAPA Focus Biomolecules
    2-AAPA inhibits glutathione reductase and thioredoxin reductase,IC50s=6.7 and 8.7 μM respectively, and impairs mitochondrial function.1 May be used to induce a cellular model of thiol oxidative stress.2  Enhances...

  • Focus Biomolecules supplier, chemical structure of Alamethicin | Pore-forming antimicrobial peptide | CAS 27061-78-5
    Alamethicin (27061-78-5) is a membrane permeabilizing, pore-forming agent.1 Applications include: [32P] incorporation into phosphatidylinositols2, permeabilization of sarcoplasmic reticulum vesicles3 and mitochondria4 and...

  • Focus Biomolecules cell signaling tech supplier, chemical structure of Antibiotic A-23187 | Ca2+ ionophore | CAS 52665-69-7
    Antibiotic A-23187 (52665-69-7) is a highly selective divalent cation ionophore, commonly used to increase intracellular Ca2+ levels in intact cells (though it is most selective for Mn2+).1 It uncouples oxidative...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Apoptolidin | Apoptosis inducer | CAS 194874-06-1
    Apoptolidin (194874-06-1) is a powerful inducer of apoptosis in a variety of cancer cell lines.1 Is believed to act via inhibition of F0F1-ATPase2 but correlation studies indicate that a second mechanism may be the actual...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Arecoline HBr | ACAT1 inhibitor | CAS 300-08-3
    Arecoline (CAS 300-8-3) is a covalent inhibitor of ACAT1 which binds to and disrupts only ACAT1 tetramers (IC50=11.1 μM). ACAT2 and DLAT are not inhibited. Tyrosine407 phosphorylation activates mitochondrial acetyl-CoA...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure Artesunate | Kills cancer stem cells | CAS 88495-63-0
    Artesunate (88495-63-0) is a semisynthetic derivative of the natural product artemisinin which is clinically useful for treatment of malaria and other parasitic diseases. Depolarizes mitochondrial membrane via generation of...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Auranofin | IKK inhibitor | CAS 34031-32-8
    Auranofin (34031-32-8) is a disease-modifying antirheumatic drug (DMARD) , It is a potent inhibitor of selenoenzyme thioredoxin reductase and IκB kinase (IKK) by modifying Cys-179. Auranofin is an efficient inducer of...

  • Bakuchiol | Antioxidant
    Bakuchiol (10309-37-2) is a natural terpenoid antioxidant.1 Inhibits oxidative stress-induced decrease in mitochondrial membrane potential and associated release of pro-apoptotic factors.2 Protects against acute lung injury...

  • BAM15 | Mitochondrial protonophore uncoupler
    BAM15 (210302-17-3) is a mitochondrial protonophore uncoupler with fewer off-target effects (EC50 = 270 nM in L6 myoblast mitochondria.)1,2 Compared to FCCP, an uncoupler of equal potency, BAM15 stimulates a higher maximum...

  • BAY 87-2243 | HIF-1 / Mitochondrial complex I inhibitor
    BAY 87-2243 (1227158-85-1) potently inhibits HIF-1 reporter gene activity (IC50 = 0.7 nM) and CA9 protein expression (IC50 = 2.0 nM).1 It inhibited HIF-1α and HIF-2α protein accumulation in hypoxic H460 cells and...

  • Focus Biomolecules cell signaling supplier, chemical structure Beauvericin | Disrupts mitochondrial volume | CAS 26048-05-5
    Beauvericin (CAS 26048-05-5) induces apoptosis in A549 cancer cells.1 Disrupts mitochondrial volume regulation.2 Antifungal activity acting via inhibition of both multidrug efflux and TORC1 kinase.3 Crosses the blood-brain...

  • Focus Biomolecules chemical structure of Betulinic Acid | Induces mitochondrial permeability pore opening | CAS 472-15-1
    Betulinic acid (472-15-1) is a natural Lupane triterpenoid from white birch tree (Betula pubescens). Induces apoptosis in a variety of cell lines.1 Induces mitochondrial permeability transition pore opening.2  Acts as a...

  • Focus Biomolecules reagent supplier, chemical structure of Bongkrekic Acid | Inhibits MPT pore opening | CAS 11076-19-0
    Bongkrekic acid (11076-19-0) is a potent inhibitory ligand of the mitochondrial adenine nucleotide translocase (ANT).1 Inhibits mitochondrial permeability transition pore opening.2,3 Delivery of bongkrekic acid to...

  • Brequinar sodium | Dihydroorotate dehydrogenase inhibitor, antiviral
    Brequinar sodium (96201-88-6) is an inhibitor of dihydroorotate dehydrogenase (DHODH)1,2 with IC50’s between 0.2 and 5.8 µM in various cell lines3 and 20 nM in isolated enzyme4. It reduced leukemic cell burden,...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of C22 Ceramide | MCSR inhibitor | CAS 27888-44-4
    C22 Ceramide is a long-chain ceramide containing behenic acid. Mitochondrial-to-cytosolic stress response (MCSR) is a recently identified stress response which can be induced by increased synthesis of fatty acids...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of CAPE | Inhibits NFkB activation | CAS 104594-70-9
    CAPE (104594-70-9) is an antioxidant that inhibits NFκB activation and the growth of transformed cells. CAPE inhibits lipid peroxidation and displays antiinflammatory activity. Cell permeable. References/Citations1)...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Carnosic acid | Antioxidant | CAS 3650-09-7
    Carnosic acid (3650-09-7) is an antioxidant and free radical scavenger. Increases cellular levels of glutathione (GSH) and prevents 6-hydroxydopamine-induced cell death in SH-SY5Y cells1. Carnosic acid-stimulation of GSH...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Cereulide | Mitochondrial toxin | CAS 157232-64-9
    Cereulide (CAS 157232-64-9) is an emetic toxin produced by Bacillus cereus. Acts as an ionophore with high selectivity for K+. Stimulates swelling and respiration in rat liver mitochondria.1  It is a lipophilic...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of CGP-37157 | MPTP inhibitor | CAS 75450-34-9
    CGP-37157 (75450-34-9) inhibits the mitochondrial Na+-Ca2+ exchanger (NCX) in isolated heart mitochondria, IC50=0.36 µM.1 Does not inhibit the plasmalemmal NCX.2  Also inhibits voltage-gated Ca2+ channels in...

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