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  • (R)-(+)-Etomoxir Na | Carnitine palmitoyltransferase inhibitor
    Etomoxir (828934-41-4) is an irreversible inhibitor of mitochondrial carnitine palmitoyl transferase 1 (CPT1).1 It is widely used to study fatty acid oxidation. Etomoxir has been investigated as a therapeutic agent for heart...

  • Alamethicin | Pore-forming antimicrobial peptide
    Alamethicin (27061-78-5) is a membrane permeabilizing, pore-forming agent.1 Applications include: [32P] incorporation into phosphatidylinositols2, permeabilization of sarcoplasmic reticulum vesicles3 and mitochondria4 and...

  • Focus Biomolecules cell signaling tech supplier, chemical structure of Antibiotic A-23187 | Ca2+ ionophore | CAS 52665-69-7
    Antibiotic A-23187 (52665-69-7) is a highly selective divalent cation ionophore, commonly used to increase intracellular Ca2+ levels in intact cells (though it is most selective for Mn2+).1 It uncouples oxidative...

  • Apoptolidin | Apoptosis inducer
    Apoptolidin (194874-06-1) is a powerful inducer of apoptosis in a variety of cancer cell lines.1 Is believed to act via inhibition of F0F1-ATPase2 but correlation studies indicate that a second mechanism may be the actual...

  • Arecoline HBr | ACAT1 inhibitor
    Arecoline (300-8-3) is a covalent inhibitor of ACAT1 which binds to and disrupts only ACAT1 tetramers (IC50=11.1 μM). ACAT2 and DLAT are not inhibited. Tyrosine407 phosphorylation activates mitochondrial acetyl-CoA...

  • Artesunate | Kills cancer stem cells / Depolarizes mitochondria
    Artesunate (88495-63-0) is a semisynthetic derivative of the natural product artemisinin which is clinically useful for treatment of malaria and other parasitic diseases. Depolarizes mitochondrial membrane via generation of...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Auranofin | IKK inhibitor | CAS 34031-32-8
    Auranofin (34031-32-8) is a disease-modifying antirheumatic drug (DMARD) , It is a potent inhibitor of selenoenzyme thioredoxin reductase and IκB kinase (IKK) by modifying Cys-179. Auranofin is an efficient inducer of...

  • Bakuchiol | Antioxidant
    Bakuchiol (10309-37-2) is a natural terpenoid antioxidant.1 Inhibits oxidative stress-induced decrease in mitochondrial membrane potential and associated release of pro-apoptotic factors.2 Protects against acute lung injury...

  • Beauvericin | Disrupts mitochondrial volume
    Induces apoptosis in A549 cancer cells.1 Disrupts mitochondrial volume regulation.2 Antifungal activity acting via inhibition of both multidrug efflux and TORC1 kinase.3 Crosses the blood-brain barrier in mice.4 Inhibits...

  • Focus Biomolecules chemical structure of Betulinic Acid | Induces mitochondrial permeability pore opening | CAS 472-15-1
    Betulinic acid (472-15-1) is a natural Lupane triterpenoid from white birch tree (Betula pubescens). Induces apoptosis in a variety of cell lines.1 Induces mitochondrial permeability transition pore opening.2  Acts as a...

  • Focus Biomolecules reagent supplier, chemical structure of Bongkrekic Acid | Inhibits MPT pore opening | CAS 11076-19-0
    Bongkrekic acid (11076-19-0) is a p potent inhibitory ligand of the mitochondrial adenine nucleotide translocase (ANT)1. Inhibits mitochondrial permeability transition pore opening2,3. Delivery of bongkrekic acid to the...

  • C22 Ceramide | Structure | supplier
    C22 Ceramide is a  long-chain ceramide containing behenic acid. Mitochondrial-to-cytosolic stress response (MCSR) is a recently identified stress response which can be induced by increased synthesis of fatty acids...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of CAPE | Inhibits NFkB activation | CAS 104594-70-9
    CAPE (104594-70-9) is an antioxidant that inhibits NFκB activation and the growth of transformed cells. CAPE inhibits lipid peroxidation and displays antiinflammatory activity. Cell permeable. References/Citations1)...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Carnosic acid | Antioxidant | CAS 3650-09-7
    Carnosic acid (3650-09-7) is an antioxidant and free radical scavenger. Increases cellular levels of glutathione (GSH) and prevents 6-hydroxydopamine-induced cell death in SH-SY5Y cells1. Carnosic acid-stimulation of GSH...

  • Cereulide | Mitochondrial toxin
    An emetic toxin produced by Bacillus cereus. Acts as an ionophore with high selectivity for K+. Stimulates swelling and respiration in rat liver mitochondria.1  It is a lipophilic cyclopeptide and is rapidly absorbed in...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of CGP-37157 | MPTP inhibitor | CAS 75450-34-9
    CGP-37157 (75450-34-9) inhibits the mitochondrial Na+-Ca2+ exchanger (NCX) in isolated heart mitochondria, IC50=0.36 mM.1 Does not inhibit the plasmalemmal NCX.2  Also inhibits voltage-gated Ca2+ channels in intact...

  • Focus Biomolecules supplier, chemical structure of CL-316243 | beta 3-adrenergic agonist / antiobesity | CAS 151126-84-0
    CL-316243 (151126-84-0) is a potent and selective β-3 adrenergic receptor agonist. (EC50= 3 nM) Displays anti-obesity and anti-diabetic effects in mice. It increases brown fat thermogenesis and metabolic rate and...

  • Focus Biomolecules, chemical structure CT-2584 | Inhibitor of CTP: choline-phosphate cytidylyltransferase | CAS 166981-13-1
    CT-2584 (166981-13-1; free base) is a cytotoxic agent that alters phospholipid biosynthesis via inhibition of CTP:choline-phosphate cytidylyltransferase causing an increase in phosphatidylinositol with decreasing levels of...

  • Focus Biomolecules supplier, structure Cyclosporin A | Inhibits mitochondrial permeability pore opening | CAS 59865-13-3
    Cyclosporin A (59865-16-6) is an immunosupressant. The CsA-cyclophilin complex binds to and inhibits calcineurin, a type 2B phosphatase. Cell permeable. References/Citations1) Liu et al. (1993), FK506 and cyclosporin:...

  • Decylubiquinone | MPTP inhibitor
    Decylubiquinone (55486-00-5) inhibits the Ca2+ dependent mitochondrial permeability transition pore (MPTP) without inhibiting respiration.1 Maximum effect on Ca2+ retention capacity of rat liver mitochondria at 100 μM...

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