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Mitochondrial transporters

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  • Focus Biomolecules reagent supplier, chemical structure of Bongkrekic Acid | Inhibits MPT pore opening | CAS 11076-19-0
    Bongkrekic acid (11076-19-0) is a p potent inhibitory ligand of the mitochondrial adenine nucleotide translocase (ANT)1. Inhibits mitochondrial permeability transition pore opening2,3. Delivery of bongkrekic acid to the...

  • Focus Biomolecules cell signaling reagent supplier, structure KB-R7943 mesylate | TRPC channel blocker | CAS 182004-65-5
    KB-R7943 (182004-65-5) is a potent and selective inhibitor of the reversed Na+/Ca2+ exchanger (NCE or NCX; IC50's = 1.2-2.4 μM in cardiomyocytes, smooth muscle cells, NCX1-transfected fibroblasts1; 0.7 μM in cultured...

  • Focus Biomolecules cell signaling supplier, chemical structure Lonidamine | Inhibits Cancer Cell Metabolism | CAS 50264-69-2
    Lonidamine (50264-69-2) was originally investigated as an antispermatogenic agent.1 Lonidamine has been shown to decrease oxygen consumption as well as aerobic and anaerobic glycolysis in tumor cells leading to apoptosis.2...

  • Focus Biomolecules supplier, chemical structure of MitoBloCK-6 | Mitochondrial import inhibitor | CAS 303215-67-0
    MitoBloCK-6 inhibits redox-regulated protein translocation into mitochondria. It attenuates the import of Erv1 substrates by inhibition of Erv1 oxidase activity (the import of Tim23 and AAC was decreased by ~50% at 20 μM)...

  • Focus Biomolecules supplier, chemical structure of PK-11195 | Mitochondrial benzodiazepine receptor ligand | CAS 85532-75-8
    PK-11195 (85532-75-8) is a selective and potent peripheral benzodiazepine receptor, PBR (or TSPO, translocator protein) antagonist.1,2 It has been shown to chemosensitize tumor cells to a variety of chemotherapeutic agents...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Puromycin | Translation inhibitor | CAS 58-58-2
    Puromycin (58-58-2) is an aminonucleoside antibiotic derived from Streptomyces alboniger. It is a protein synthesis inhibitor that disrupts peptide transfer on ribosomes causing premature chain termination.1 It is an...

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