Respiratory Chain

Artesunate (88495-63-0) is a semisynthetic derivative of the natural product artemisinin which is clinically useful for treatment of malaria and other parasitic diseases. Depolarizes mitochondrial membrane via generation of...

Ilicicolin H (12689-26-8) is a potent inhibitor of the mitochondrial cytochrome bc1 reductase.1 Displays potent and broad spectrum antifungal activity.2 References/Citations 1) Singh et al. (2013), Structure-activity...

Metformin HCl (1115-70-4) is a clinically useful antidiabetic agent. Lowers plasma glucose levels and improves insulin sensitivity. Inhibits hepatic gluconeogenesis by activation of the AMP-activated protein kinase (AMPK)...

TTFA (326-91-0) blocks the respiratory chain complex II causing inhibition of mitochondrial respiration.  Respiratory chain complex II inhibition is caused via binding of TTFA to two ubiquinone binding sites, Qp...