Respiratory Chain

BAM15 (210302-17-3) is a mitochondrial protonophore uncoupler with fewer off-target effects (EC50 = 270 nM in L6 myoblast mitochondria.)1,2 Compared to FCCP, an uncoupler of equal potency, BAM15 stimulates a higher maximum...

Dyclonine HCl (536-43-6) is a topical anesthetic which has been used for oral and throat analgesia.1 Enhances neuronal mitochondrial function, potentiating respiration and providing protection against insults associated with...

Ilicicolin H (12689-26-8) is a potent inhibitor of the mitochondrial cytochrome bc1 reductase.1 Displays potent and broad spectrum antifungal activity.2 References/Citations 1) Singh et al. (2013), Structure-activity...

Metformin HCl (1115-70-4) is a clinically useful antidiabetic agent. Lowers plasma glucose levels and improves insulin sensitivity. Inhibits hepatic gluconeogenesis by activation of the AMP-activated protein kinase (AMPK)...

QNZ (545380-34-5) was originally described as a potent inhibitor of NF-κB activation (IC50 = 11 nM) and TNF-α production (IC50 = 7 nM).1,2 It indirectly inhibits the NF-κB pathway via inhibition of...