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Product Details

ML-60218 | RNA Polymerase III inhibitor

A broad spectrum inhibitor of RNA polymerase III from S. Cerevisiae as well as from human cells, IC50=32 mM and 27 mM respectively.1   Combined treatment with ML-60218 and an HDAC inhibitor caused augmented suppression of colony formation, induction of cell cycle arrest and apoptotic cell death in human pancreatic adenocarcinoma cells.2

References/Citations

1) Wu et al. (2003), Novel small-molecule inhibitors of RNA polymerase III; Eukaryot. Cell, 2 256
2) Yee et al. (2012), Targeting developmental regulators of zebrafish exocrine pancreas as a therapeutic approach in human pancreatic cancer; Biol. Open, 1(4) 295

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ML-60218 | Structure | Supplier

Catalog#  10-1481-0005

$90.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
577784-91-9
Catalog Number:
10-1481
Activity:
RNA Polymerase III inhibitor
Alternate Names:
RNA Polymerase III inhibitor
Molecular Weight:
452.38
Molecular Formula:
C19H15Cl2N3O2S2
Solubility:
Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 5 mg/ml with warming)
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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