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Product Details

ML335 | Trek-1,2 activator

Two-pore domain potassium (K2P) channels of the TREK subfamily regulate neuronal excitability, influence pain, temperature perception and responses to anaesthetics. ML-335 (825658-06-8) is a novel, selective TREK-1,2 activator with EC50s of 14.3 and 5.2 μM1. It represents an important new pharmacological tool for studying the physiology of TREK channels.

References/Citations
1) Lolicato et al. (2017), K2P2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site; Nature, 547 364

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Catalog#  10-3648-0005

$55.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
825658-06-8
Catalog Number:
10-3648
Activity:
TREK-1,2 activator
Chemical Name:
N-(2,4-Dichlorobenzyl)-4-(methylsulfonamido)benzamide
Molecular Weight:
373.25
Molecular Formula:
C15H14Cl2N2O3S
Solubility:
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 20 mg/ml with warming).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20° (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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