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Product Details

N,N-Dimethylsphingosine | Inhibits sphingosine kinase

N,N-Dimethylsphingosine (119567-63-4) is a synthetic derivative of D-erythro-sphingosine (Cat.# 10-2287). Endogenous sphingolipid.1 Inhibits sphingosine kinase (IC50 = 5 μM).2 N,N-Dimethylsphingosine induces apoptosis in a variety of cell lines.3

References/Citations
1) Igarashi et al. (1990), A specific enhancing effect of N,N-dimethylsphingosine on epidermal growth factor receptor autophosphorylation. Demonstration of its endogenous occurrence (and the virtual absence of unsubstituted sphingosine) in human epidermoid carcinoma A431 cells; J. Biol. Chem., 265 5385
2) Yatomi et al. (1996), N,N-dimethylsphingosine inhibition of sphingosine kinase and sphingosine 1-phosphate activity in human platelets; Biochemistry, 35 626
3) Gude et al. (2008), Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a "come-and-get-me" signal; FASEB J., 22 2629

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Catalog#  10-2285

$57.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
119567-63-4
Catalog Number:
10-2285
Activity:
Inhibits sphingosine kinase
Chemical Name:
(2S,3R,E)-2-(Dimethylamino)octadeca-4-ene-1,3-diol
Molecular Weight:
327.56
Molecular Formula:
C20H41NO2
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
Physical Properties:
White or off-white solid or viscous oil
Purity:
98% by TLC
NMR (Conforrms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 3 years as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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