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Neurodegeneration

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  • Focus Biomolecules supplier, structure of 24(S)-Hydroxycholesterol | Endogenous cholesterol metabolite | CAS 474-73-7
    $50.00
    24S Hydroxycholesterol (474-73-7) is an important cholesterol metabolite (cholesterol 24-hydroxylase) found in the brain.1 It is an endogenous agonist of the nuclear receptor LXR.2 It has been shown to induce cell death in...

  • Focus Biomolecules supplier, chemical structure of 27-Hydroxycholesterol | Cholesterol oxidation metabolite | CAS 20380-11-4
    $40.00
    27-Hydroxycholesterol (20380-11-4) is a metabolite resulting from the action of sterol 27-hydroxylase on cholesterol. Concentrations of 27-hydroxycholesterol are elevated in patients with Alzheimers disease and mild...

  • Focus Biomolecules supplier, chemical structure of ABT-418 HCl | Nicotinic acetylcholine receptor agonist | CAS 147388-83-8
    $90.00
    ABT-418 (CAS 147388-83-8) is an agonist at neuronal nicotinic acetylcholine receptors displaying the highest potency at α4β2 and α2β2 subtypes (EC50= approximately 6 and 11 μM, respectively).1...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of AK-7 | SIRT2 inhibitor | CAS 420831-40-9
    $50.00
    AK-7 (420831-40-9) is a selective Sirt2 inhibitor (IC50=15.5 μM) which does not inhibit Sirt1 or Sirt3.1 It down regulates cholesterol biosynthesis genes in primary striatal neurons.1 AK-7 displays...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure Apomorphine HCl | Dopamine agonist | CAS 41372-20-7
    $40.00
    Apomorphine (41372-20-7) is an archetypal dopamine pan-receptor agonist. Displays anti-Parkinsons activity in vivo.1 Protects against MPTP-induced neurotoxicity in a mouse model.2 In clinical use for Parkinson’s...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure AR-A 014418 | GSK-3 inhibitor | CAS 487021-52-3
    $65.00
    AR-A 014418 (487021-52-3) is a selective glycogen synthase kinase 3 (GSK-3) inhibitor, IC50 = 104 nM. Inhibits β-amyloid-mediated neurodegeneration in hippocampal slices. Anti-inflammatory activity. Cell permeable...

  • Focus Biomolecules supplier, chemical structure of Benztropine mesylate | Induces remyelination of neurons | CAS 132-17-2
    $38.00
    Benztropine mesylate (132-17-2) is a centrally acting M1 muscarinic acetylcholine receptor antagonist (Ki=0.59 nM, rat).1 Also inhibits the dopamine transporter (Ki=160 nM).2 Benztropine mesylate enhances remyelination and...

  • Focus Biomolecules supplier, chemical structure of Bexarotene | Retinoid RXR agonist | CAS 153559-49-0
    $40.00
    Bexarotene (153559-49-0) is a highly potent and selective retinoid X receptor (RXR) agonist (EC50=28, 25, 20 nM for RXRα, β, γ respectively).1 Clinically useful antineoplastic agent for cutaneous T-cell...

  • BI-D1870 | p90 ribosomal S6 kinase inhibitor
    $90.00
    BI-D1870 (501437-28-1) is an inhibitor of p90 ribosomal S6 kinase (RSK; IC50’s = RSK1, 31 nM; RSK2, 24 nM; RSK3, 18 nM; RSK4, 15 nM) with selectivity over other AGC kinases.1 It protected mice from experimental...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of BML-259 | CDK5/p25 inhibitor | CAS 267254-00-2
    $60.00
    BML-259 (267654-00-2) is a potent inhibitor of Cdk5/p25 (IC50 = 64 nM) and Cdk2 (IC50 = 98nM).1 References/Citations1) Helal et al. (2004) Discovery and SAR of 2-aminothiazole inhibitors of cyclin-dependent kinase 5/p25 as a...

  • Focus Biomolecules cell signaling reagent supplier, Bromocriptine mesylate | Dopamine D2/D3 agonist | CAS 22260-51-1
    $65.00
    Bromcriptine mesylate (22260-51-1) is a dopamine D2 receptor agonist. Inhibits prolactin production3. Decreases cocaine self-administration in the rat4. Active in vivo. References/Citations1) Nilsson and Hokfelt (1978),...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of C-646 | HAT inhibitor | CAS 328968-36-1
    $80.00
    C-646 (328968-36-1) is a potent and selective inhibitor of the histone acetyl transferase p300/CBP (Ki=400 nM ). Induces apoptosis in prostate cancer cells. C-646 enhances fear extinction memory and synaptic plasticity in...

  • Focus Biomolecules reagent supplier, chemical structure of C-DIM 12 | Nurr1 activator; NFkB inhibitor | CAS 178946-89-9
    $55.00
    C-DIM 12 (178946-89-9) activates the orphan nuclear receptor Nurr1 and inhibits bladder cancer growth.1,2 Nurr1 is a suppressor of NFkB-related neuroinflammatory genes in microglia and astrocytes and C-DIM 12 suppresses...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure Compound 115-7c | HSP70 modulator | CAS 908074-72-6
    $90.00
    Compound 115-7c (908074-72-6) acts as an artificial co-chaperone for HSP70.1 The activity of compound 115-7c mirrors those of HSP40 stimulating the ATPase and protein-folding activities of prokaryotic HSP70. Increases tau...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Cycloheximide-N-ethylethanoate | FKBP12 inhibitor
    $65.00
    FKBP12 inhibitor (IC50=4.4 µM) with neuroregenerative properties. Does not inhibit protein synthesis (as does cycloheximide).1 Mimics a helical peptide in target proteins for binding to the immunophillin Mip homolog,...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of CZC-54252 | LRRK2 | CAS 1191911-27-9
    $85.00
    CZC-54252 (1191911-27-9) is a novel, potent and selective inhibitor of the leucine-rich repeat kinase-2 (LRRK2), IC50 = 1.28 nM. Also inhibits G2019S mutant LRRK2, IC50 = 1.85 nM1. CZC-54252 attenuates the neuronal damage...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of DAPT | gamma-secretase inhibitor | CAS 208255-80-5
    $60.00
    DAPT (208255-80-5)is an inhibitor of γ-secretase (IC50 in human primary neurons = 115 nM for total Aβ or 200 nM for Aβ42 specifically)1. Oral administration of DAPT has been shown to reduce levels of Aβ...

  • Focus Biomolecules supplier, chemical structure of Entacapone | COMT inhibitor - anti-Parkinsons | CAS 130929-57-6
    $40.00
    Entacapone (130929-57-6) is a potent catechol O-methyltransferase (COMT) inhibitor (IC50 = 14.3, 20.1 and 73.3 nM for rat liver soluble COMT, total COMT and membrane-bound COMT respectively).1 Increases bioavailability of...

  • Focus Biomolecules supplier, chemical structure of Epoxomicin | Irreversible 20S proteasome inhibitor | CAS 134381-21-8
    $145.00
    Epoxomicin (134381-21-8) is a potent, selective and cell permeable irreversible inhibitor of the 20S proteasome.1 It does not inhibit non-proteasomal proteases such as papain, chymotrypsin, trypsin, calpain and cathepsin B...

  • Focus Biomolecules supplier, chemical structure of Ethopropazine HCl | Promotes stem cell self renewal | CAS 1094-08-2
    $90.00
    Ethopropazine HCl (1094-08-2) is a butyrylcholinesterase inhibitor.1 Reduces drug-induced extrapyramidal motor syndrome. Parkinson's disease therapeutic.2 Alleviates thermal hyperalgesia in neuropathic rats...

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