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Alzheimers

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  • Focus Biomolecules supplier, chemical structure of 27-Hydroxycholesterol | Cholesterol oxidation metabolite | CAS 20380-11-4
    27-Hydroxycholesterol | Cholesterol oxidation metabolite
    $40.00
    27-Hydroxycholesterol (20380-11-4) is a metabolite resulting from the action of sterol 27-hydroxylase on cholesterol. Concentrations of 27-hydroxycholesterol are elevated in patients with Alzheimers disease and mild...

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  • Focus Biomolecules supplier, chemical structure of ABT-418 HCl | Nicotinic acetylcholine receptor agonist | CAS 147388-83-8
    ABT-418 HCl | Nicotinic acetylcholine receptor agonist; cognition enhancer
    $90.00
    ABT-418 (CAS 147388-83-8) is an agonist at neuronal nicotinic acetylcholine receptors displaying the highest potency at α4β2 and α2β2 subtypes (EC50= approximately 6 and 11 μM, respectively).1...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure AR-A 014418 | GSK-3 inhibitor | CAS 487021-52-3
    AR-A 014418 | GSK-3 inhibitor
    $65.00
    AR-A 014418 (487021-52-3) is a selective glycogen synthase kinase 3 (GSK-3) inhibitor, IC50 = 104 nM. Inhibits β-amyloid-mediated neurodegeneration in hippocampal slices. Anti-inflammatory activity. Cell permeable...

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  • Focus Biomolecules supplier, chemical structure of Bexarotene | Retinoid RXR agonist | CAS 153559-49-0
    Bexarotene | Retinoid RXR agonist
    $40.00
    Bexarotene (153559-49-0) is a highly potent and selective retinoid X receptor (RXR) agonist (EC50=28, 25, 20 nM for RXRα, β, γ respectively).1 Clinically useful antineoplastic agent for cutaneous T-cell...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of BML-259 | CDK5/p25 inhibitor | CAS 267254-00-2
    BML-259 | CDK5/p25 inhibitor
    $60.00
    BML-259 (267654-00-2) is a potent inhibitor of Cdk5/p25 (IC50 = 64 nM) and Cdk2 (IC50 = 98nM).1 References/Citations1) Helal et al. (2004) Discovery and SAR of 2-aminothiazole inhibitors of cyclin-dependent kinase 5/p25 as a...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure Compound 115-7c | HSP70 modulator | CAS 908074-72-6
    Compound 115-7c | HSP70 modulator
    $90.00
    Compound 115-7c (908074-72-6) acts as an artificial co-chaperone for HSP70.1 The activity of compound 115-7c mirrors those of HSP40 stimulating the ATPase and protein-folding activities of prokaryotic HSP70. Increases tau...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of DAPT | gamma-secretase inhibitor | CAS 208255-80-5
    DAPT | gamma-secretase inhibitor
    $60.00
    DAPT (208255-80-5)is an inhibitor of γ-secretase (IC50 in human primary neurons = 115 nM for total Aβ or 200 nM for Aβ42 specifically)1. Oral administration of DAPT has been shown to reduce levels of Aβ...

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  • Focus Biomolecules cell signaling supplier, chemical structure of FPS-ZM1 | RAGE receptor antagonist | CAS 945714-67-0
    FPS-ZM1 | RAGE receptor antagonist
    $60.00
    FPS-ZM1 (945714-67-0) is a high-affinity RAGE (Receptor for Advanced Glycation End products) receptor antagonist (IC50 = 0.6 μM). It lowers levels of Aβ via binding to the V domain of RAGE and can block multiple...

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  • Focus Biomolecules cell signaling tech supplier, structure Galanthamine HBr | Acetylcholinesterase inhibitor | CAS 1953-04-4
    Galanthamine HBr | Acetylcholinesterase inhibitor
    $25.00
    Galanthamine HBr (1953-04-4) is a long-acting, centrally active acetylcholinesterase inhibitor, IC50 = 410 nM1. Allosteric potentiator at neuronal nicotinic ACh receptors2. Prevents β-amyloid-induced apoptosis in...

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  • Focus Biomolecules cell signaling supplier, chemical structure of Ibotenic acid | NMDA & mGluR agonist | CAS 2552-55-8
    Ibotenic acid | NMDA and mGluR agonist
    $50.00
    Ibotenic acid (60573-88-8) is a conformationally restricted analog of glutamate which occurs naturally in Amanita mascaria and related mushrooms.  It is a non-specific glutamate receptor (both NMDA and mGluR) agonist.1...

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  • Focus Biomolecules supplier, chemical structure of Indirubin-3'-monoxime | GSK-3 beta and CDK inhibitor | CAS 160807-49-8
    Indirubin-3'-monoxime | GSK-3 beta and CDK inhibitor
    $60.00
    Indirubin-3'-monoxime (160807-49-8) is a potent GSK-3β inhibitor (IC50=22 nM)1. Also inhibits CDK1 (IC50=180 nM) and CDK5 (IC50=100 nM)1. Displays antimitotic properties and induces endoreplication following prophase...

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  • Focus Biomolecules reagent supplier, chemical structure Memantine HCl | NMDA antagonist | Anti-Alzheimer's | CAS 41100-52-1
    Memantine HCl | NMDA antagonist / Anti-Alzheimer's
    $50.00
    Memantine HCl (CAS 41100-52-1) is an NMDA noncompetitive, low affinity, open channel blocker, IC50~1 mM at   -60 mV in rat retinal ganglion cells.1 Displays neuroprotective effects in excitotoxic conditions.2...

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  • Focus Biomolecules supplier, chemical structure of Mitoquinone | Mitochondria-targeted antioxidant | CAS 444890-40-9
    Mitoquinone | Mitochondria-targeted antioxidant
    $70.00
    Mitoquinone (444890-40-9) is a mitochondria-targeted antioxidant. Displays cardio- and neuroprotective effects.1 Displays beneficial effects in mouse models of Alzheimer's disease.2 Mitoquinone protects pancreatic...

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  • Focus Biomolecules supplier, chemical structure of Monastrol | Kinesin Eg5 and mitosis inhibitor | CAS 254753-54-3
    Monastrol | Kinesin Eg5 and mitosis inhibitor
    $80.00
    Monastrol (254753-54-3) is a potent, cell-permeable, small molecule inhibitor of mitosis. Monastrol-arrested cells are characterized by monopolar spindles.1 Does not affect other motor proteins or tubulin. Specifically...

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  • N-Eicosanoyl serotonin | Neuroprotective
    N-Eicosanoyl serotonin | Neuroprotective
    $50.00
    N-eicosanoyl serotonin is a natural product found in coffee which synergizes with caffeine in protecting the brain in models of α-synucleinopathy1. It inhibits the PP2A methylesterase maintaining PP2A in a highly...

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  • Focus Biomolecules cell signaling reagent supplier, structure of Sodium Valproate | HDAC inhibitor | CAS 1069-66-5
    Na Valproate | HDAC inhibitor
    $26.00
    Sodium Valproate (1069-66-5) is a histone deacetylase inhibitor (IC50 = 400µM).1 Demonstrates neuroprotective, anticancer, and anti-inflammatory activity.2  Inhibits Aβ production, reduced neuritic plaque...

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  • Focus Biomolecules supplier, chemical structure of Nilvadipine | Syk inhibitor, Calcium channel blocker | CAS 75530-68-6
    Nilvadipine | Syk inhibitor and Calcium channel blocker
    $70.00
    Nilvadipine (75530-68-6) is a novel DHP L-type Ca2+ channel blocker that also inhibits Syk.1 Blocks Aβ production, APPβ secretion and reduces BACE-1 expression in CHO cells over-expressing Aβ in vitro...

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  • Focus Biomolecules reagent supplier, chemical structure of Noopept | Nootropic & neuroprotective agent | CAS 157115-85-0
    Noopept | Nootropic and neuroprotective agent
    $50.00
    Noopept (157115-85-0) is a novel proline-containing dipeptide with nootropic and cognition-enhancing activity.1 Rescues α-synuclein amyloid toxicity in cellular models.2 Stimulates the expression of NGF and BDNF in rat...

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  • Phosphoramidon | Neutral endopeptidase inhibitor
    Phosphoramidon | Neutral endopeptidase inhibitor
    $100.00
    Phosphoramidon (119942-99-3) inhibits neutral endopeptidase 24.11 (NEP; Neprilysin; EC 3.4.24.11), Ki=2 nM.1 Also inhibits neprilysin 2 (Ki~2 nM).2 Also inhibits endothelin-converting enzyme (IC50 = 0.68 μM).3 Induces a...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of PNU 282987 | nAChR agonist | CAS 123464-89-1
    PNU 282987 | nAChR agonist
    $40.00
    PNU 282987 (CAS 123464-89-1) is a selective α7 nicotinic acetylcholine receptor (nAChR) agonist (Ki = 26 nM).1  The a7 nAChR is a potential therapeutic target of cognitive deficits in diseases such as Alzheimer's,...

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