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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of C-646 | HAT inhibitor | CAS 328968-36-1
    $80.00
    C-646 (328968-36-1) is a potent and selective inhibitor of the histone acetyl transferase p300/CBP (Ki=400 nM ). Induces apoptosis in prostate cancer cells. C-646 enhances fear extinction memory and synaptic plasticity in...

  • Focus Biomolecules reagent supplier, chemical structure of C-DIM 12 | Nurr1 activator; NFkB inhibitor | CAS 178946-89-9
    $55.00
    C-DIM 12 (178946-89-9) activates the orphan nuclear receptor Nurr1 and inhibits bladder cancer growth.1,2 Nurr1 is a suppressor of NFkB-related neuroinflammatory genes in microglia and astrocytes and C-DIM 12 suppresses...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Cycloheximide-N-ethylethanoate | FKBP12 inhibitor
    $65.00
    FKBP12 inhibitor (IC50=4.4 µM) with neuroregenerative properties. Does not inhibit protein synthesis (as does cycloheximide).1 Mimics a helical peptide in target proteins for binding to the immunophillin Mip homolog,...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Filipin III | Cholesterol probe | CAS 480-49-9
    $120.00
    Filipin III (480-49-9) is a polyene macrolide antibiotic. It may be used in a double staining procedure for the detection of lipoproteins.1 Binds specifically to cholesterol forming a fluorescent complex which may be used...

  • Focus Biomolecules cell signaling supplier, chemical structure of Ibotenic acid | NMDA & mGluR agonist | CAS 2552-55-8
    $50.00
    Ibotenic acid (60573-88-8) is a conformationally restricted analog of glutamate which occurs naturally in Amanita mascaria and related mushrooms.  It is a non-specific glutamate receptor (both NMDA and mGluR) agonist.1...

  • Focus Biomolecules cell signaling supplier, chemical structure of Leonurine | Neuroinflammation inhibitor | CAS 24697-74-3
    $48.00
    Leonurine (CAS 24697-74-3) inhibits microglial overactivation and attenuates Aβ(1-40)-induced cognitive impairments in rats via JNK and NF-κB pathways.1 Inhibits the formation of advanced glycation end products.2...

  • Focus Biomolecules supplier, chemical structure of LM22A-4 | TrkB small molecule agonist | CAS 37988-18-4
    $120.00
    LM22A-4 (37988-18-4) is a small molecule BDNF mimetic displaying neurotrophhic activity. Partial agonist at TRKB and activates TRKB signaling. In in vitro models of neurodegenerative disease, it prevented neuronal...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of MDL29,951 | GPR17 activator | CAS 130798-51-5
    $85.00
    MDL29,951 (130798-51-5) is a new, highly specific, small molecule activator of GPR171 that has been shown to be active in intact cells1. The ability to specifically activate GPR17 allows for the study of the exact role GPR17...

  • RGFP966 | Selective HDAC3 inhibitor
    $70.00
    RGFP966 (1357389-11-7) is a selective inhibitor of HDAC3 (IC50 = 80 nM, no other HDACs inhibited @ 15µM).1 It facilitates the extinction of cocaine-seeking behavior in mice and transforms subthreshold learning events...

  • Rufinamide | Anticonvulsant / Improves cognition
    $25.00
    Rufinamide (106308-44-5) is a clinically useful anticonvulsant medication.1 Its mechanism of action is believed to be inhibition of Nav1.1 and Nav1.6 activation.2  Rufinamide improved cognitive function and increased...

  • Focus Biomolecules cell signaling reagent supplier, structure of SU-4312 | VEGFR / PDGFR kinase inhibitor | CAS 5813-07-7
    $70.00
    SU-4312 (5812-07-7) is a potent selective inhibitor of VEGFR kinase (also known as Flk-1 and KDR). Inhibition of the activated kinase (IC50 = 0.4 μM) is 100-fold less than inhibition of the unactivated kinase (IC50 = 0.04...

  • Focus Biomolecules supplier, chemical structure of Tolcapone | COMT inhibitor | TTR aggregation inhibitor | CAS 134308-13-7
    $50.00
    Tolcapone (134308-13-7) is a catechol O-methyltransferase inhibitor (COMT), inhibiting both brain and peripheral enzymes.1 Potent inhibitor of alpha-synuclein and beta-amyloid oligomerization and fibrillogenesis protecting...

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