Repaglinide | Kir6 blocker
Repaglinide (135062-02-1) is a blocker of the ATP-sensitive potassium channel Kir6 with hypoglycemic activity.1 Clinically useful antidiabetic agent. It displays 30-fold selectivity for pancreatic Kir6.2/SUR1 over
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Repaglinide (135062-02-1) is a blocker of the ATP-sensitive potassium channel Kir6 with hypoglycemic activity.1 Clinically useful antidiabetic agent. It displays 30-fold selectivity for pancreatic Kir6.2/SUR1 over
T0901317 (293754-55-9) is a potent high affinity liver X receptor (LXRα and β) agonist, EC50~50 nM.1 Upregulates expression of ABCA1, a reverse cholesterol transporter, resulting in
PF-670462 (950912-80-8) is a potent inhibitor of casein kinase 1ε/δ (CK1ε, IC50 = 7.7 nM; CK1δ, IC50 = 14 nM).1 It is a circadian clock modifier that caused robust
Huperzine A (102518-79-6) is a nootropic alkaloid from the club moss Huperzia serrata that reversibly inhibits acetylcholinesterase (AChE, preferentially the tetrameric form, Ki = 7 nM)1, and antagonizes NMDA receptors
Repaglinide (135062-02-1) is a blocker of the ATP-sensitive potassium channel Kir6 with hypoglycemic activity.1 Clinically useful antidiabetic agent. It displays 30-fold selectivity for pancreatic Kir6.2/SUR1 over
Clemastine fumarate (14976-57-9) is a histamine H1 antagonist with anti-muscarinic effects at the M1 receptor. Enhances remyelination in a mouse model of demyelination.1 Displays protective role
RECTAS (101862-47-9), a pre-mRNA splice modulator (Rectifier of Aberrant Splicing), was discovered in a small molecule screen for compounds that rectify aberrant IKBKAP splicing in cells
Repaglinide (135062-02-1) is a blocker of the ATP-sensitive potassium channel Kir6 with hypoglycemic activity.1 Clinically useful antidiabetic agent. It displays 30-fold selectivity for pancreatic Kir6.2/SUR1 over
Linopirdine (113168-57-3) increases acetylcholine release and improves performance in animal models of learning and memory via blockade of Kv7 (KCNQ) voltage-gated potassium channels.1-3 Linopirdine is a
GSK2606414 (1337531-36-8) is a potent (IC50 = 0.4 nM) and selective (against a panel of 294 kinases) inhibitor of protein kinase R-like endoplasmic reticulum kinase (PERK), an
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