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Parkinsons

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  • Apomorphine HCl | 41372-20-7 | Structure | Supplier
    $40.00
    Apomorphine (41372-20-7) is an archetypal dopamine pan-receptor agonist. Displays anti-Parkinsons activity in vivo.1 Protects against MPTP-induced neurotoxicity in a mouse model.2 In clinical use for Parkinson’s...

  • Focus Biomolecules cell signaling reagent supplier, Bromocriptine mesylate | Dopamine D2/D3 agonist | CAS 22260-51-1
    $65.00
    Bromcriptine mesylate (22260-51-1) is a dopamine D2 receptor agonist. Inhibits prolactin production3. Decreases cocaine self-administration in the rat4. Active in vivo. References/Citations1) Nilsson and Hokfelt (1978),...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of CZC-54252 | LRRK2 | CAS 1191911-27-9
    $85.00
    CZC-54252 (1191911-27-9) is a novel, potent and selective inhibitor of the leucine-rich repeat kinase-2 (LRRK2), IC50 = 1.28 nM. Also inhibits G2019S mutant LRRK2, IC50 = 1.85 nM1. CZC-54252 attenuates the neuronal damage...

  • Entacapone | COMT inhibitor - anti-Parkinsons
    $40.00
    Entacapone (130929-57-6) is a potent catechol O-methyltransferase (COMT) inhibitor (IC50 = 14.3, 20.1 and 73.3 nM for rat liver soluble COMT, total COMT and membrane-bound COMT respectively).1 Increases bioavailability of...

  • Focus Biomolecules supplier, chemical structure of Epoxomicin | Irreversible 20S proteasome inhibitor | CAS 134381-21-8
    $145.00
    Epoxomicin (134381-21-8) is a potent, selective and cell permeable irreversible inhibitor of the 20S proteasome.1 It does not inhibit non-proteasomal proteases such as papain, chymotrypsin, trypsin, calpain and cathepsin B...

  • Focus Biomolecules supplier, chemical structure of Ethopropazine HCl | Promotes stem cell self renewal | CAS 1094-08-2
    $90.00
    Ethopropazine HCl (1094-08-2) is a butyrylcholinesterase inhibitor.1 Reduces drug-induced extrapyramidal motor syndrome. Parkinson's disease therapeutic.2 Alleviates thermal hyperalgesia in neuropathic rats...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of LDN-57444 | DUB inhibitor | CAS 668467-91-2
    $90.00
    LDN-57444 (668467-91-2) inhibits ubiquitin C-terminal hydrolase (UCH-L1) (Ki=0.4 μM). Decreases proteasome activity and increases levels of ubiquitinated proteins. Induces apoptosis. LDN-57444 causes dramatic alterations...

  • Focus Biomolecules supplier, chemical structure of Mitoquinone | Mitochondria-targeted antioxidant | CAS 444890-40-9
    $70.00
    Mitoquinone (444890-40-9) is a mitochondria-targeted antioxidant. Displays cardio- and neuroprotective effects.1 Displays beneficial effects in mouse models of Alzheimer's disease.2 Mitoquinone protects pancreatic...

  • MPEP HCl | mGlu5 Receptor antagonist
    $35.00
    MPEP HCl (219911-35-0) is a potent (IC50 = 36 nM for quisqualate-stimulated phosphoinositide hydrolysis) and selective (over mGlu1b, -2, -3, -4a, -6, -7b, and -8a) antagonist of the metabotropic glutamate receptor subtype 5...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of P7C3 | Neuroprotective agent | CAS 301353-96-8
    $60.00
    P7C3 exerts proneurogenic activity by protecting newborn neurons from apoptosis. Prolonged administration to aged rats impedes neuronal death and preserves cognitive capacity.1 Delays disease progression in G93A-SOD2 mutant...

  • Pinacidil | Potassium channel opener
    $30.00
    Pinacidil (85371-64-8) activates ATP-dependent potassium channels.1,2 Induces vascular relaxation and antihypertensive effects.3  Prevents the loss of mitochondrial inner membrane potential, protecting cerebellar...

  • PNU 282987 | nAChR agonist
    $40.00
    PNU 282987 (123464-89-1) is a selective α7 nicotinic acetylcholine receptor (nAChR) agonist (Ki = 26 nM).1  The a7 nAChR is a potential therapeutic target of cognitive deficits in diseases such as Alzheimers,...

  • Rasagiline mesylate | MAO-B inhibitor, neuroprotective
    $45.00
    Rasagiline mesylate (161735-79-1) is a potent, irreversible monoamine oxidase (MAO) inhibitor selective for MAO-B (IC50=4.43 nM) over MAO-A (IC50=412 nM).1 Parkinson’s disease therapeutic.2 Displays neuroprotective and...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Rottlerin | PKCdelta inhibitor | CAS 82-08-6
    $50.00
    Rottlerin (82-08-6) has been reported to inhibit PKCδ selectively however this result has been called into question.1 Displays neuroprotective effects.2 Induces autophagy.3 Cell permeable...

  • Terguride | Dopamine D2 agonist
    $125.00
    Terguride (37686-84-3) is a semi-synthetic ergoline derivative which acts as a partial dopamine D2 agonist and 5HT2B/2C receptor antagonist. Displays antiparkinsonian effects in MPTP-treated cynomolgus monkeys1. Partial...

  • Tolcapone | COMT inhibitor / TTR aggregation inhibitor
    $50.00
    Tolcapone (134308-13-7) is a catechol O-methyltransferase inhibitor (COMT), inhibiting both brain and peripheral enzymes.1 Potent inhibitor of alpha-synuclein and beta-amyloid oligomerization and fibrillogenesis protecting...

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