SBI-553 | ß-Arrestin-biased NTSR1 modulator
SBI-553 (1849603-72-0) is a potent, brain penetrant, and orally bioavailable allosteric modulator of neurotensin receptor 1 (NTSR1; EC50 = 340 nM)).1 It acts as a ß-Arrestin-biased
Neurosciences
Focus Biomolecules research products for neuroscience include modulators of targets including ion channels, nitric oxide pathways, neurotransmitters, lipid signaling, cannabinoids, epigenetics; for areas such as neurodegeneration, pain, mood disorders, neuroinflammation, addiction, memory, and more.
Addiction
Varenicline tartrate | α4ß2 partial agonist/Smoking cessation aid
Varenicline (375815-87-5) is a partial agonist of the α4β2 neuronal nicotinic acetylcholine receptor (EC50 = 2.3 µM) and a full agonist at α7 neuronal nicotinic receptors.1 Clinically useful
KNK437 | HSP70 inhibitor
CAS:
218924-25-5
Catalog Number:
10-5561
Activity:
HSP70 inhibitor
Chemical Names:
3-(1,3-Benzodioxol-5-ylmethylene)-2-oxo-1-pyrrolidinecarboxaldehyde
Molecular Weight:
245.23
Molecular Formula:
C13H11NO4
Solubility:
Soluble in DMSO (30 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Cannabinoids
Oleamide | Endogenous sleep-inducing lipid
CAS:
301-02-0
Catalog Number:
10-2923
Activity:
Endogenous sleep-inducing lipid
Chemical Names:
9Z-Octadecenamide; cis-9-Octadecenamide; Oleic acid amide
Molecular Weight:
281.48
Molecular Formula:
C18H35NO
Solubility:
Soluble in DMSO (25 mg/ml); Ethanol (40 mg/ml)
Physical Properties:
White to off-white solid
Purity:
99% TLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT
AM251 | Cannabinoid CB1 antagonist
CAS:
183232-66-8
Catalog Number:
10-2007
Activity:
Cannabinoid CB1 receptor antagonist
Chemical Name:
N-(Piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide
Molecular Weight:
555.24
Molecular Formula:
C22H21Cl2IN4O
Solubility:
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 13 mg/ml)
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Anandamide | Endogenous cannabinoid
CAS:
94421-68-8
Catalog Number:
10-2009
Activity:
Endogenous cannabinoid
Alternate Names:
Arachidonoylethanolamide; AEA
Chemical Name:
N-(2-Hydroxyethyl)-5Z,8Z,11Z,14Z-eicosatetraenamide
Molecular Weight:
347.54
Molecular Formula:
C22H27NO2
Solubility:
Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 50 mg/ml).
Physical Properties:
Colorless oil
Purity:
98% by TLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-80°C
Stability:
Stable for 1 year from date of purchase as supplied. Subject to oxidation – protect from air. Solutions in degassed DMSO or ethanol may be stored under nitrogen or argon at -80°C for up to 1 month.
Shipping Code:
Blue Ice
Epigenetics
BG45 | HDAC3 selective inhibitor
BG45 (926259-99-6) is a potent and selective HDAC3 inhibitor (IC50 = 289 nM), IC50s for HDAC1, 2 and 6 = 2, 2.2 and >20 mM respectively.1 Inhibits tumor
TTK21 | CBP/p300 histone acetyltransferase activator
CAS:
709676-56-2
Catalog Number:
10-5669
Activity:
Histone acetyltransferase CBP/p300 activator
Chemical Names:
N-[4-Chloro-3-(trifluoromethyl)phenyl]-2-propoxybenzamide
Molecular Weight:
357.76
Molecular Formula:
C17H15ClF3NO2
Solubility:
Soluble in DMSO (50 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT
JQ1 (+) | BET Bromodomain inhibitor
CAS:
1268524-70-4
Catalog Number:
10-1584
Activity:
BET Bromodomain inhibitor
Chemical Name:
(6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid 1,1-dimethylethyl ester
Molecular Weight:
456.99
Molecular Formula:
C23H25ClN4O2S
Solubility:
Soluble in DMSO (up to 60 mg/ml) or in Ethanol (up to 46 mg/ml).
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
Shipping Code:
RT
Ion channels
VU0810464 | Kir3 activator
VU0810464 (2126040-21-7) is a potent (Kir3.1/3.2; GIRK1/2 EC50 = 165 nM) activator of G protein-gated inwardly-rectifying potassium channels (Kir3; GIRK).1,2 Displays selectivity for Kir3.1/3.2 versus Kir3.1/3.4
NS 1619 | Selective KCa1.1 activator
NS 1619 (153587-10-0) is a selective activator of large conductance Ca(2+)-dependent potassium channels (BKCa or KCa1.1).1,2 It was able to increase blood-brain tumor barrier permeability in
ML418 | Kir7.1/6.2 blocker
ML418 (1928763-08-9) is a blocker of the inward rectifier potassium channels Kir7.1 (IC50 = 310nM) and Kir6.2 (equipotent) with metabolic and pharmacokinetic parameters suitable for in
Memory and learning
Linopirdine dihydrochloride | Kv7 Blocker
Linopirdine (113168-57-3) increases acetylcholine release and improves performance in animal models of learning and memory via blockade of Kv7 (KCNQ) voltage-gated potassium channels.1-3 Linopirdine is a
Probucol | Antioxidant hypercholesterolemic agent
Probucol (23288-49-5) is a unique antilipidemic drug which inhibits the oxidation of LDL cholesterol preventing the genesis of macrophage-derived foam cells and thus suppressing the formation
Nimodipine | L-type calcium channel blocker
CAS:
66085-59-4
Catalog Number:
10-1321
Activity:
L-type calcium channel blocker
Chemical Name:
1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methyloxyethyl 1-methylethyl ester
Alternate Names:
BAY-e 9736
Molecular Weight:
418.44
Molecular Formula:
C21H26N2O7
Solubility:
Soluble in DMSO (up to 40 mg/ml)
Physical Properties:
Pale-yellow solid
Purity:
98% by HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Neural stem cells
Dibutyryl cAMP | Cell permeable cAMP
CAS:
16980-89-5
Catalog Number:
10-2627
Activity:
Cell permeable cAMP
Chemical Name:
N6,O2′-Dibutyryl adenosine 3′,5′-cyclic monophosphate sodium salt
Alternate Name:
Bucladesine Na
Molecular Weight:
491.37
Molecular Formula:
C18H23N5O8P ∙ Na
Solubility:
Soluble in DMSO (up to 50 mg/ml) or in water (up to 50 mg/ml).
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
Shipping Code:
RT
Fluoxetine HCl | Serotonin reuptake inhibitor
CAS:
56296-78-7
Catalog Number:
10-2728
Activity:
Serotonin reuptake inhibitor
Chemical Name:
(±)-N-Methyl-γ-[4-(trifluoromethyl)phenoxy]benzenepropanamine hydrochloride
Alternate Names:
LY-110,140
Molecular Weight:
345-79
Molecular Formula:
C17H18F3NO • HCl
Solubility:
Soluble in DMSO (up to 35 mg/ml) or in Water (up to 4 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Rufinamide | Anticonvulsant / Improves cognition
CAS:
106308-44-5
Catalog Number:
10-4275
Activity:
Anticonvulsant / Improves cognition
Chemical Name:
1-[(2,6-Difluorophenyl)methyl]-1H-1,2,3-triazole-4-carboxamide
Molecular Weight:
238.19
Molecular Formula:
C10H8F2N4O2
Solubility:
Soluble in DMSO (up to 10 mg/ml)
Physical Properties:
Off-white solid
Purity:
98% by HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
- RT
Neurodegeneration
RECTAS | pre-mRNA splicing modulator
RECTAS (101862-47-9), a pre-mRNA splice modulator (Rectifier of Aberrant Splicing), was discovered in a small molecule screen for compounds that rectify aberrant IKBKAP splicing in cells
Doxycycline monohydrate | Broad spectrum antibiotic
Doxycycline monohydrate (17086-28-1) is a broad-spectrum tetracycline antibiotic.1 Inhibits matrix metalloproteases.2 Promotes wound repair by inhibiting collagen degradation in rat models.3 Displays neuroprotective effects in neurodegenerative
Repaglinide | Kir6 blocker
Repaglinide (135062-02-1) is a blocker of the ATP-sensitive potassium channel Kir6 with hypoglycemic activity.1 Clinically useful antidiabetic agent. It displays 30-fold selectivity for pancreatic Kir6.2/SUR1 over
Neuroinflammation
TPPU | Soluble epoxide hydrolase inhibitor
TPPU (1222780-33-7) is a potent and selective inhibitor of both murine and human soluble epoxide hydrolase, IC50=2.8 and 3.7 nM respectively.1 It alleviated blood brain barrier
Muscone | Cardioprotective and neuroprotective agent
Muscone (541-92-3) is a macrocyclic ketone found naturally in a glandular secretion of the musk deer which acts at human odorant receptor OR5AN1 and is used
P7C3-A20 | NAMPT activator/Proneurogenic agent
CAS:
1235481-90-9
Catalog Number:
10-3414
Activity:
NAMPT activator/proneurogenic agent
Chemical Names:
3,6-Dibromo-ß-fluoro-N-(3-methoxyphenyl)-9H-carbazole-9-propanamine
Molecular Weight:
506.21
Molecular Formula:
C22H19Br2FN2O
Solubility:
Soluble in DMSO (40 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% TLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Neuroprotection
Cafestol | Neuroprotective
Cafestol (469-83-0) is a bioactive diterpene found in coffee.1 It displays a number of interesting protective effects including stimulation of glutathione S-transferase activity1, and protection against
XMU-MP-1 | Potent and selective MST1/2 kinase inhibitor
XMU-MP-1 (2061980-01-4) is a potent, reversible, and selective inhibitor of the HIPPO pathway kinases MST1 and MST2 (IC50s = 71 nM and 38 nM respectively).1 It
TPPU | Soluble epoxide hydrolase inhibitor
TPPU (1222780-33-7) is a potent and selective inhibitor of both murine and human soluble epoxide hydrolase, IC50=2.8 and 3.7 nM respectively.1 It alleviated blood brain barrier
Neurotransmitters
6,7-ADTN HBr | Dopamine receptor agonist
6,7-ADTN HBr (13575-86-5) is a broad spectrum dopamine receptor agonist.1,2 Demonstrates a marked selectivity for the human dopamine D3 receptor.3 6,7-ADTN and psychostimulants such as cocaine
Dihydroergotamine mesylate | Vascular serotonin receptor agonist
CAS:
6190-39-2
Catalog Number:
10-3400
Activity:
Vascular serotonin receptor agonist
Chemical Names:
(5’a,10a)-9,10-Dihydro-12′-hydroxy-2′-methyl-5′-(phenylmethyl)ergotaman-3′,6′,18-trione, mesylate
Molecular Weight:
679.79
Molecular Formula:
C33H37N5O5·CH3SO3H
Solubility:
Soluble in DMSO (25 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT
Bupropion HCl | Monoamine transporter inhibitor
CAS:
31677-93-7
Catalog Number:
10-2462
Activity:
Monoamine transporter inhibitor
Chemical Names:
1-(3-Chlorophenyl)-2-[(1,1-dimethylethyl)amino]-1-propanone hydrochloride
Molecular Weight:
276.20
Molecular Formula:
C13H18ClNO·HCl
Solubility:
Soluble in DMSO (40 mg/ml)
Physical Properties:
White solid
Purity:
>98% HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Neurovascular/BBB
CK-666 | ARP2/3 inhibitor
CAS:
442633-00-3
Catalog Number:
10-3346
Activity:
ARP2/3 inhibitor
Chemical Name:
2-Fluoro-N-[2-methyl-1H-indol-3-yl)ethyl]benzamide
Molecular Weight:
296.34
Molecular Formula:
C18H17FN2O
Solubility:
Soluble in DMSO (up to 45 mg/ml) or in Ethanol (up to 30 mg/ml)
Physical Properties:
Cream-colored solid
Purity:
98% by TLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Enzastaurin | PKC inhibitor
CAS:
170364-57-5
Catalog Number:
10-2132
Activity:
PKC inhibitor
Chemical Name:
3-(1-Methyl-1H-indol-3-yl)-4-[1-[1-(2-pyridinylmethyl)-4-piperidinyl]-1H-indol-3-yl]-1H-pyrrole-2,5-dione
Alternate Names:
LY-317615
Molecular Weight:
515.61
Molecular Formula:
C32H29N5O2
Solubility:
Soluble in DMSO (up to 7 mg/ml with warming)
Physical Properties:
Orange solid
Purity:
98% by HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Ibudilast | Neuroinflammation inhibitor
CAS:
50847-11-5
Catalog Number:
10-2236
Activity:
Neuroinflammation inhibitor
Chemical Name:
3-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine
Alternate Names:
2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridine-3-yl 1-propanone; KC-404; AV411
Molecular Weight:
230.31
Molecular Formula:
C14H18N2O
Solubility:
Soluble in DMSO (up to 25 mg/ml) or Ethanol (up to 20 mg/ml)
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Pain
YL-365 | GPR34 antagonist
YL-365 is a potent (IC50 = 17 nM) and selective antagonist of GPR34, a GPCR for lysophosphatidylserine.1 GPR34 is highly expressed in various immune cells and
Pazopanib | Multi-receptor tyrosine kinase inhibitor
Pazopanib (444731-52-6) inhibits multiple receptor tyrosine kinases including VEGFR1,2 and 3 (IC50s=10, 30, 47 nM respectively) and PDGFRα, β and c-Kit (IC50s=71, 84, 74 nM respectively)
Muscone | Cardioprotective and neuroprotective agent
Muscone (541-92-3) is a macrocyclic ketone found naturally in a glandular secretion of the musk deer which acts at human odorant receptor OR5AN1 and is used
Other Neurosciences
TH257 | Allosteric LIM kinase inhibitor
CAS:
2244678-29-1
Catalog Number:
10-4418
Activity:
Allosteric LIM kinase inhibitor
Chemical Names:
N-Butyl-4-[(phenylamino)sulfonyl]-N-(phenylmethyl)benzamide
Molecular Weight:
422.54
Molecular Formula:
C24H26N2O3S
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
White to off-white glassy solid
Purity:
>98% HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
NQDI-1 | ASK1 inhibitor
CAS:
175026-96-7
Catalog Number:
10-5144
Activity:
ASK1 inhibitor
Chemical Names:
2,7-Dihydro-2,7-dioxo-3H-naphtho[1,2,3-de]quinoline-1-carboxylic acid, ethyl ester
Molecular Weight:
319.31
Molecular Formula:
C19H13NO4
Solubility:
Soluble in DMSO ( up to 3 mg/ml)
Physical Properties:
Yellow solid
Purity:
>98% TLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Pseurotin A | Fungal metabolite with neuritogenic activity
CAS:
58523-30-1
Catalog Number:
10-2630
Activity:
Fungal metabolite with potent neuritogenic activity
Chemical Names:
Fermentation product of Aspergillus fumigatus
Molecular Weight:
431.44
Molecular Formula:
C22H25NO8
Solubility:
Soluble in DMSO (10 mg/ml)
Physical Properties:
White solid
Purity:
99% HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
