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  • Aripiprazole | Dopamine receptor partial agonist
    Aripiprazole (129722-2-9) is a clinically useful neuroleptic and antipsychotic agent.1 Dopamine D2 receptor antagonist and autoreceptor agonist.2 Improves symptoms of psychosis associated with Alzheimer's disease...

  • BD1047 dihydrobromide | Selective sigma-2 antagonist
    BD1047 (138356-21-5) is a potent and selective sigma-1 antagonist (IC50’s:  σ1 = 0.93nM, σ2 = 47nM). .1 Pretreatment of mice with BD1047 reduced convulsions, lethality, and locomotor activity induced...

  • BD1063 dihydrochloride | Selective sigma-1 antagonist
    BD1063 (206996-13-6) is potent and selective sigma-1 antagonist (IC50’s: σ1 = 9nM, σ2 = 449nM).1 BD1063 abolished mechanical and thermal hyperalgesia in mice with carrageenan-induced acute inflammation by...

  • Focus Biomolecules cell signaling reagent supplier, Bromocriptine mesylate | Dopamine D2/D3 agonist | CAS 22260-51-1
    Bromcriptine mesylate (22260-51-1) is a dopamine D2 receptor agonist. Inhibits prolactin production3. Decreases cocaine self-administration in the rat4. Active in vivo. References/Citations1) Nilsson and Hokfelt (1978),...

  • FSC-231 | PICK1 PDZ domain inhibitor
    FSC-231 is the first small-molecule inhibitor of the PDZ domain in protein interacting with C kinase 1 (PICK1). Binds to PICK1 PDZ domain with affinity similar to that of the endogenous peptide ligands (Ki~10.1 µM)...

  • Focus Biomolecules supplier, chemical structure of GBR-12909 2HCl | Dopamine reuptake inhibitor | CAS 67469-78-7
    GBR-12909 2HCl (67469-78-7) is a potent and selective inhibitor of dopamine reuptake (Ki = 1 nM) with greater than 100 fold selectivity over serotonin and noradrenaline.1 GBR-12909 2HCl also acts as a potent sigma...

  • MPEP HCl | mGlu5 Receptor antagonist
    MPEP HCl (219911-35-0) is a potent (IC50 = 36 nM for quisqualate-stimulated phosphoinositide hydrolysis) and selective (over mGlu1b, -2, -3, -4a, -6, -7b, and -8a) antagonist of the metabotropic glutamate receptor subtype 5...

  • Focus Biomolecules cell signaling reagent supplier, structure Nalmefene HCl | Opioid receptor antagonist | CAS 58895-64-0
    Nalmefene (58895-64-0) is an opioid antagonist. Very similar activity profile to naloxone (Cat.# 10-2442) however displays slower onset and longer duration of action1. Antagonizes the effects of salvinorin2 (κ-agonist)...

  • RGFP966 | Selective HDAC3 inhibitor
    RGFP966 (1357389-11-7) is a selective inhibitor of HDAC3 (IC50 = 80 nM, no other HDACs inhibited @ 15µM).1 It facilitates the extinction of cocaine-seeking behavior in mice and transforms subthreshold learning events...

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