Epigenetics
Showing 1–12 of 42 results
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Dedifferentiation
(±) Tranylcypromine hemisulfate | Demethylase inhibitor
Tranylcypromine (13492-01-8) is an irreversible and non-selective monoamine oxidase inhibitor.1,2 It has been shown to inhibit the histone demethyl...$40.00 – $150.00 Select options -
Cancer
2′-Deoxy-5-fluorocytidine | Irreversible DNA methyl transferase inhibitor
2'-Deoxy-5-fluorocytidine (10356-76-0) is a DNA methyltransferase inhibitor currently in clinical trials for breast cancer and other solid tumors.1...$50.00 – $120.00 Select options -
Cancer
5-Azacytidine | DNA hypomethylation agent
5-Azacytidine (320-67-2) is specific inhibitor of DNA methyltransferase.1 Incorporates into DNA and covalently reacts with and inhibits DNA methylt...$20.00 – $80.00 Select options -
Bioactive Lipids
AK-7 | SIRT2 inhibitor
AK-7 (420831-40-9) is a selective Sirt2 inhibitor (IC50=15.5 μM) which does not inhibit Sirt1 or Sirt3.1 It down regulates cholesterol biosynthesis...$55.00 – $220.00 Select options -
Antifungals
Apicidin | HDAC inhibitor
Apicidin (183506-66-3) is a fungal toxin that is a potent, cell permeable inhibitor of histone deacetylases (HDAC's).1 It also displays antitumor p...$55.00 – $220.00 Select options -
Epigenetics
BIX-01294 | Histone Methyltransferase inhibitor
BIX-01294 (935693-62-2) is a selective inhibitor of G9a histone methyltransferase (G9aHMTase; IC50 = 1.7 μM) as well as GLP HMTase (IC50 = 38 μM) l...$60.00 – $240.00 Select options -
Epigenetics
BML-210 | HDAC inhibitor
BML-210 (537034-17-6) is a novel non-hydroxamic acid HDAC inhibitor. IC50=5-10 μM (HeLa nuclear extract). Induces growth inhibition, proapoptotic a...$50.00 – $200.00 Select options -
Epigenetics
BML-278 | SIRT1 activator
BML-278 (120533-76-8) is a structurally novel activator of SIRT1 (EC50=1 μM). Displays selectivity over SIRT2 and 3 (EC50=25 and 50 μM respectively...$60.00 – $240.00 Select options -
Cancer
C-646 | HAT inhibitor
C-646 (328968-36-1) is a potent and selective inhibitor of the histone acetyl transferase p300/CBP (Ki=400 nM ). Induces apoptosis in prostate canc...$80.00 – $320.00 Select options -
Apoptosis
Chaetocin | Lys methyltransferase inhibitor
Chaetocin (28097-69-1) is an antimicrobial fungal metabolite. Selective inhibitor of lysine specific histone methytransferase.1 Chaetocin has an an...$45.00 – $180.00 Select options -
Epigenetics
CPTH2 | HAT inhibitor
CPTH2 (357649-93-5) is a selective inhibitor of the histone acetyltransferase Gcn5P both in vitro and in vivo (IC50 = 0.8 mM). In vitro, the HAT in...$69.00 – $250.00 Select options -
Epigenetics
Daminozide | KDM2/7 demethylase inhibitor
Daminozide (1596-84-5) is a selective inhibitor of the KDM2/7 JmjC subfamily of histone demethylases. IC50=1.5, 0.55 and 2.1 μM for KDM2A, PHF8 and...$40.00 – $90.00 Select options
