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Epigenetics

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of ML-324 | JMJD2 inhibitor | CAS 1222800-79-4
    $50.00
    ML324 (1222800-79-4) inhibits JMJD2 histone demethylases. Represses the expression of viral (HCMV and HSV-1) immediate early genes (IC50 ~ 10 μM) and abrogates infection. ML-324 represses the reactivation of HSV from the...

  • Focus Biomolecules supplier, chemical structure of MS-275 (Entinostat) | HDAC inhibitor | CAS 209783-80-2
    $50.00
    MS-275 (Entinostat - 209783-80-2) is a potent HDAC inhibitor. Selective for HDAC1 (IC50 = 300 nM) over HDAC3 (IC50 = 8 μM) and HDAC8 (IC50 100 μM).1 In vivo, MS-275, has been shown to inhibit tumor growth via induction...

  • Focus Biomolecules cell signaling reagent supplier, structure of Sodium Valproate | HDAC inhibitor | CAS 1069-66-5
    $26.00
    Sodium Valproate (1069-66-5) is a histone deacetylase inhibitor (IC50 = 400µM).1 Demonstrates neuroprotective, anticancer, and anti-inflammatory activity.2  Inhibits Aβ production, reduced neuritic plaque...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Panobinostat | HDAC inhibitor | CAS 404950-80-7
    $60.00
    Panobinostat (404950-80-7) is a potent inhibitor of class I and II HDACs.1 Cotreatment with panobinostat and an HSP90 inhibitor caused synergistic apoptosis in human CML-BC and AML cells.2 A potent antimyeloma...

  • Focus Biomolecules cell signaling reagent supplier, structure of Phenylbutyrate Na | HDAC inhibitor | CAS 1716-12-7
    $35.00
    Phenylbutyrate Na (1716-12-7) is a histone deacetylase (HDAC) inhibitor. Inhibits proliferation, migration and invasion of a number of cancer cell lines. Phenylbutyrate Na induces differentiation, and apoptosis. Active in...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Piceatannol | SIRT1 activator | CAS 10083-24-6
    $45.00
    Piceatannol (10083-24-6) is a naturally occurring analog of resveratrol (Cat.# 10-1057). Inhibits nonreceptor kinases Syk and Lyk (IC50 approximately 10 μM)1. Piceatannol stimulates Sirt12. References/Citations1) Seow et...

  • Focus Biomolecules cell signaling reagent supplier, structure of Resveratrol | Antioxidant/SIRT1 activator | CAS 201-36-0
    $45.00
    Resveratrol (501-36-0) is a naturally occurring phenolic antioxidant. Displays antitumor and antiplatelet effects1. Activates SIRT1 and increases longevity in yeast2. Resveratrol ameliorates ageing-related phenotypes by...

  • Focus Biomolecules supplier, chemical structure of RG-108 | DNA Methyltransferase inhibitor | CAS 48208-26-0
    $40.00
    RG-108 (48208-26-0) is a non-nucleoside DNA methyltransferase inhibitor. IC50=115 nM1 Inhibits DNA methylation in human tumor cell lines without toxicity2. RG-108 enhances the reversion of neural progenitor cells to the...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Romidepsin | HDAC inhibitor | CAS 128517-07-7
    $50.00
    Romidepsin (128517-07-7) is a potent and selective inhibitor of class I histone deacetylases (HDACs), IC50 = 36, 47, 510 and 14,000 nM for HDAC1, 2, 4 and HDAC6, respectively.1 Induces apoptosis in a variety of cell...

  • Focus Biomolecules supplier, chemical structure of RVX-208 | BET bromodomain inhibitor | CAS 1044870-39-4
    $68.00
    RVX-208 (1044870-39-4) is a potent BET bromodomain antagonist with IC50 of 0.510 μM for BD2, with approximately 170-fold selectivity over BD11,2. RVX-208 increases apolipoprotein A-1 and HDL cholesterol in vitro and in...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of SAHA | HDAC inhibitor | CAS 149647-78-9
    $35.00
    SAHA (149647-78-9) is a potent and selective histone deacetylase inhibitor. Induces apoptosis in a variety of tumor cell lines. SAHA synergizes with kinase inhibitors to kill CNS tumor cells. Cell permeable...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of SirtAct | SIRT1 activator | CAS 839699-72-8
    $80.00
    SirtAct (839699-72-8) is a Sirt1 activator (233% at 10 μM)1 Suppresses TNFα release from THP-1 cells and stimulates adipogenesis in 3T3L1 cells1. SIRT1 stimulation by SirtAct leads to decreased tissue factor...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Sirtinol | SIRT inhibitor | CAS 410536-97-9
    $55.00
    Sirtinol (410536-97-9) is an inhibitor of sirtuin family enzymes including human SIRT1 (IC50=60 μM), human SIRT2 (IC50=58 μM), and yeast Sir2 (IC50=48 μM) with no inhibition of human HDAC1. Active in vivo and in...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Splitomicin | Sirt1 inhibitor | CAS 5690-03-9
    $48.00
    Splitomycin (5690-03-9) was initially shown to inhibit Sir2p (the yeast Sirt1 homolog) and create a conditional phenocopy of a sir2 deletion mutant in S. cerevisiae1. Cells grown in the presence of the drug have silencing...

  • Focus Biomolecules supplier, structure of TC-E 5033 | Arginine methyltransferase 1 (PRMT1) inhibitor | CAS 17328-16-4
    $60.00
    TC-E 5003 (17328-16-4) is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor, IC50 = 1.5 μM. Displays no activity against CARM1 and Set7/9 methyltransferases. TC-E 5003 inhibits growth of MCF7a breast...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of TM-2-51 | HDAC8 activator | CAS 4921-82-8
    $50.00
    TM-2-51 (4921-82-8) is a highly potent and isozyme selective activator of recombinant HDAC8. Increases the activity of HDAC8 by a factor of 12 at 10 μM. No activation of other HDACs is observed. TM-2-51 rescues the...

  • Focus Biomolecules supplier, chemical structure of Triacetyl resveratrol | SIRT activator, prodrug | CAS 42206-94-0
    $55.00
    Triacetyl resveratrol (CAS 42206-94-0) is a resveratrol prodrug. One method for increasing the half-life of resveratrol in vivo is acetylation of the phenolic OH groups. Deacetylation takes place in vivo or in intact cells...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Trichostatin A | HDAC inhibitor | CAS 58880-19-6
    $85.00
    Trichostatin A (58880-19-6) is a potent and selective histone deacetylase (HDAC) inhibitor (Ki = 3.4 nM). Induces reversion of ras transformed cells to normal morphology. Trichostatin A induces dedifferentiation of...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure Tubastatin A HCl | HDAC inhibitor | CAS 1310693-92-5
    $55.00
    Tubastatin A (1310693-92-5) is a potent and highly selective inhibitor of HDAC6 (IC50 = 15 nM, >1000-fold selectivity against other HDAC isoforms, approx. 60-fold versus HDAC8).1 It displayed anti-inflammatory and...

  • Focus Biomolecules cell signaling supplier, chemical structure of UNC1999 | Methyltransferase inhibitor | CAS 1431612-23-5
    $59.00
    UNC1999 (1431612-23-5) is an orally bioavailable, highly selective inhibitor of both wild-type and mutant EZH1 and EZH2 lysine methyltransferases (IC50's = 45 nM and 2 nM respectively).1 Inhibition of EZH2 with UNC1999...