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Memory and Learning

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  • ABT-418 HCl | Nicotinic acetylcholine receptor agonist; cognition enhancer
    Agonist at neuronal nicotinic acetylcholine receptors displaying the highest potency at α4β2 and α2β2 subtypes (EC50= approximately 6 and 11 μM, respectively).1 Displays anxiolytic activity in a rat...

  • ANA-12 | TrkB antagonist
    ANA-12 (219755-25-3) is a TrkB receptor antagonist. Binds to two distinct receptor sites preventing activation by BDNF non-competitively, IC50 = 45.6 nM and 41.1 μM for the high and low affinity sites respectively...

  • CI-994 | HDAC Inhibitor
    CI-994 (112522-64-2) is an orally active histone deacetylase (HDAC) inhibitor, IC50 = 0.9, 0.9, 1.2 and >20 μM for HDAC1, HDAC2, HDAC3 and HDAC8 respectively.1 Mediates G1 cell cycle arrest, inhibits proliferation and...

  • Cycloserine, D(+) | NMDA, glycine site partial agonist
    D-Cycloserine (68-41-7) is a partial agonist at the glycine modulatory site of NMDA glutamatergic receptors.1 Blocks kainate-induced seizures2 and displays anticonvulsant effects3 in rat models. D-Cycloserine facilitates...

  • Focus Biomolecules cell signaling tech supplier, Idebenone | Quinone antioxidant, free radical scavenger | CAS 58186-27-9
    Idebenone (58186-27-9) is an analog of coenzyme Q10 which acts as an antioxidant1. Protects mitochondrial membranes against lipid peroxidation and blocks glutamate neurotoxicity in vitro and in vivo2. Increases NGF...

  • ISRIB | Integrated stress response inhibitor
    ISRIB (1597403-47-8) is an integrated stress response inhibitor. Potently reverses the effects of initiation factor 2α (eIF2α) phosphorylation, IC50=5 nM.1   Enhances spatial and fear-associated...

  • Linamarin | Neurotoxic cyanogenic glycoside
    Linamarin (554-35-8) is a cyanogenic glycoside defense compound produced by plants and insects.1 Found in cassava.2 Displays neurotoxic effects in rats.2 Induces memory and cognition deficits in rodents...

  • Noopept | Nootropic and neuroprotective agent
    Noopept (157115-85-0) is a novel proline-containing dipeptide with nootropic and cognition-enhancing activity.1 Rescues α-synuclein amyloid toxicity in cellular models.2 Stimulates the expression of NGF and BDNF in rat...

  • RGFP966 | Selective HDAC3 inhibitor
    RGFP966 (1357389-11-7) is a selective inhibitor of HDAC3 (IC50 = 80 nM, no other HDACs inhibited @ 15µM).1 It facilitates the extinction of cocaine-seeking behavior in mice and transforms subthreshold learning events...

  • Roflumilast | PDE4 inhibitor
    Roflumilast (162401-32-3) is a potent and selective phosphodiesterase (PDE4) inhibitor, IC50=0.7, 0.9, 0.7, 0.2 nM for PDE4A1, PDE4A4, PDE4B1 and PDE4B2 respectively.1 Clinically useful agent for treatment of COPD...

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