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Memory and Learning

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  • ABT-418 HCl | Nicotinic acetylcholine receptor agonist; cognition enhancer
    $90.00
    Agonist at neuronal nicotinic acetylcholine receptors displaying the highest potency at α4β2 and α2β2 subtypes (EC50= approximately 6 and 11 μM, respectively).1 Displays anxiolytic activity in a rat...

  • ANA-12 | TrkB antagonist
    $87.00
    ANA-12 (219755-25-3) is a TrkB receptor antagonist. Binds to two distinct receptor sites preventing activation by BDNF non-competitively, IC50 = 45.6 nM and 41.1 μM for the high and low affinity sites respectively...

  • CI-994 | HDAC Inhibitor
    $65.00
    CI-994 (112522-64-2) is an orally active histone deacetylase (HDAC) inhibitor, IC50 = 0.9, 0.9, 1.2 and >20 μM for HDAC1, HDAC2, HDAC3 and HDAC8 respectively.1 Mediates G1 cell cycle arrest, inhibits proliferation and...

  • Cycloserine, D(+) | NMDA, glycine site partial agonist
    $60.00
    D-Cycloserine (68-41-7) is a partial agonist at the glycine modulatory site of NMDA glutamatergic receptors.1 Blocks kainate-induced seizures2 and displays anticonvulsant effects3 in rat models. D-Cycloserine facilitates...

  • Idebenone | 58186-27-9 | Structure | Supplier
    $70.00
    Idebenone (58186-27-9) is an analog of coenzyme Q10 which acts as an antioxidant1. Protects mitochondrial membranes against lipid peroxidation and blocks glutamate neurotoxicity in vitro and in vivo2. Increases NGF...

  • ISRIB | Integrated stress response inhibitor
    $60.00
    ISRIB (1597403-47-8) is an integrated stress response inhibitor. Potently reverses the effects of initiation factor 2α (eIF2α) phosphorylation, IC50=5 nM.1   Enhances spatial and fear-associated...

  • Linamarin | Neurotoxic cyanogenic glycoside
    $50.00
    Linamarin (554-35-8) is a cyanogenic glycoside defense compound produced by plants and insects.1 Found in cassava.2 Displays neurotoxic effects in rats.2 Induces memory and cognition deficits in rodents...

  • Noopept | Nootropic and neuroprotective agent
    $50.00
    Noopept (157115-85-0) is a novel proline-containing dipeptide with nootropic and cognition-enhancing activity.1 Rescues α-synuclein amyloid toxicity in cellular models.2 Stimulates the expression of NGF and BDNF in rat...

  • Roflumilast | PDE4 inhibitor
    $50.00
    Roflumilast (162401-32-3) is a potent and selective phosphodiesterase (PDE4) inhibitor, IC50=0.7, 0.9, 0.7, 0.2 nM for PDE4A1, PDE4A4, PDE4B1 and PDE4B2 respectively.1 Clinically useful agent for treatment of COPD...

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