Neurodegeneration
Showing 1–12 of 58 results
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Cell Death
24(S)-Hydroxycholesterol | Endogenous cholesterol metabolite
24S Hydroxycholesterol (474-73-7) is an important cholesterol metabolite (cholesterol 24-hydroxylase) found in the brain.1 It is an endogenous agon...$50.00 – $245.00 Select options -
Alzheimers
27-Hydroxycholesterol | Cholesterol oxidation metabolite
27-Hydroxycholesterol (20380-11-4) is a metabolite resulting from the action of sterol 27-hydroxylase on cholesterol. Concentrations of 27-hydroxyc...$40.00 – $175.00 Select options -
Alzheimers
ABT-418 HCl | Nicotinic acetylcholine receptor agonist; cognition enhancer
ABT-418 (CAS 147388-83-8) is an agonist at neuronal nicotinic acetylcholine receptors displaying the highest potency at α4β2 and α2β2 subtypes (EC5...$90.00 – $360.00 Select options -
Alzheimers
Anle138b | Protein aggregation inhibitor
Anle138b is an aggregation inhibitor that modulates the formation of pathological oligomers of both prion and α-synuclein.1 In mouse models of prio...$55.00 – $195.00 Select options -
Approved Drugs
Apomorphine HCl | Dopamine agonist
Apomorphine (41372-20-7) is an archetypal dopamine pan-receptor agonist. Displays anti-Parkinsons activity in vivo.1 Protects against MPTP-induced ...$40.00 – $120.00 Select options -
Alzheimers
AR-A 014418 | GSK-3 inhibitor
AR-A 014418 (487021-52-3) is a selective glycogen synthase kinase 3 (GSK-3) inhibitor, IC50 = 104 nM. Inhibits β-amyloid-mediated neurodegeneration...$65.00 – $260.00 Select options -
Cellular Stress
Auraptene | Neuroprotective / Neuritogenic agent
Auraptene (495-02-3) is a bioactive terpenoid occurring in a variety of citrus fruits and possessing therapeutic potential.1 Displays neuritogeni...$30.00 – $98.00 Select options -
Immunology
AX-024 | Inhibitor of T cell antigen receptor (TCR)-dependent T cell activation
AX-024 (1704801-24-0) is a potent (IC50 ~ 1 nM) and specific inhibitor of T cell antigen receptor (TCR)-dependent T cell activation. It inhibited n...$90.00 – $330.00 Select options -
Cholinergics
Benztropine mesylate | Induces remyelination of neurons
Benztropine mesylate (132-17-2) is a centrally acting M1 muscarinic acetylcholine receptor antagonist (Ki=0.59 nM, rat).1 Also inhibits the dopamin...$38.00 Select options -
Alzheimers
Compound 115-7c | HSP70 modulator
Compound 115-7c (908074-72-6) acts as an artificial co-chaperone for HSP70.1 The activity of compound 115-7c mirrors those of HSP40 stimulating the...$90.00 – $360.00 Select options -
Immunology
Cycloheximide-N-ethylethanoate | FKBP12 inhibitor
FKBP12 inhibitor (IC50=4.4 µM) with neuroregenerative properties. Does not inhibit protein synthesis (as does cycloheximide).1 Mimics a helical pep...$65.00 – $260.00 Select options -
Kinases
CZC-54252 | LRRK2
CZC-54252 (1191911-27-9) is a novel, potent and selective inhibitor of the leucine-rich repeat kinase-2 (LRRK2), IC50 = 1.28 nM. Also inhibits G201...$85.00 – $340.00 Select options
